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What is best cbd oil for borderline personality

CBD for Borderline Personality Disorder – June 2022

In the United States, 75% of those diagnosed with BPD are women. However, recent research suggests that men may be equally affected by BPD but are misdiagnosed with post-traumatic stress disorder (PTSD) or depression ( 1 ) .

Psychotherapy is usually the first-line treatment for people with BPD, such as dialectical behavior therapy (DBT) and cognitive-behavioral therapy (CBT).

In some cases, however, a psychiatrist may recommend medications to treat specific symptoms, such as mood swings, depression, and other co-occurring mental disorders (2 ) .

Why People Are Turning to CBD for BPD

CBD oil can help make changes in brain chemistry that may help people with BPD gain control over their feelings.

A 2014 study published in the journal Neuroscience has found that inflammatory cytokines contribute to the development of depression in both medically ill and medically healthy individuals (3 ) .

Cytokines are hormones secreted by the immune system and can affect the function of every tissue and organ in the body, including the brain.

Increased levels of cytokine proteins cause inflammation, which can lead to depression. Meanwhile, researchers have found that CBD can help reduce inflammation.

A study showed the mechanism by which CBD inhibits inflammatory and neuropathic pain (4 ) .

CBD’s potent anti-inflammatory properties were also demonstrated in a 2018 study published in the Journal of Pharmacology and Experimental Therapeutics (5 ) .

CBD products made with hemp-derived extract can also be beneficial to people struggling with BPD.

Full-spectrum CBD oil derived from hemp contains Omega-3 fatty acids, which could have an anti-inflammatory effect on the brain and help cognitive function.

A study in the journal Lipids in Health and Disease demonstrated that omega-3 fatty acids could be a useful agent for treating depression (6 ) .

Studies indicate that many psychiatric disorders, including BPD, correlate with a deficiency in Omega-3 fatty acids in the body (7 )

Research on Omega-3 fatty acid supplementation noted that it can be an effective treatment method for both children and adults with BPD (8 ) .

How CBD Works to Help With BPD

The therapeutic effects of cannabinoids, such as CBD, are realized by their interaction with the body’s endocannabinoid system (ECS) and its specialized cannabinoid receptors.

The 5-HT1A serotonin receptors are among the endocannabinoid receptors that CBD activates. Serotonin, the happy chemical, is a neurotransmitter that contributes to feelings of well-being.

Through this interaction, these cannabinoids promote healing and balance (9 ) .

People who suffer from depression and anxiety seem to manifest reduced levels of serotonin. Similarly, people with BPD exhibit lowered serotonin levels.

Research published in the Neurochemical Research Journal indicated that cannabidiol c ould inhibit the reuptake of serotonin in the brain, making serotonin more available for the body ( 10 ) .

As CBD activates the 5-HT1A serotonin receptors, they bind to 5-HT serotonin neurotransmitters and increase serotonin production.

With better regulation of serotonin, CBD could help stabilize mood, which, in turn, combats the adverse effects of anxiety and depression that come along with BPD.

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Conclusion

There is no single cure for BPD. Moreover, managing BPD is incredibly difficult and requires hours of therapy and hard work.

However, with the right treatment combination, individuals with BPD can still lead fulfilling lives.

There is no guarantee that CBD can help anyone with BPD. Everybody is different. Thus, the way BPD manifests in individuals and the way CBD impacts people is entirely relative to the individual.

Still, CBD looks promising for BPD patients as a possible treatment for symptoms such as anxiety, depression, and inflammation.

How CBD can positively impact borderline personality disorder

Approximately 1.6 percent of adults in the U.S. suffer from borderline personality disorder (BPD), a condition characterized by difficulty regulating emotions, impulsivity, low self-image and problems creating and maintaining personal relationships.

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BPD is notoriously difficult to treat. Medications don’t often provide relief from symptoms, only intense and specifically designed psychotherapy has proven any help.

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Cannabidiol (CBD), however, shows promise as a possible treatment option for those who struggle with BPD.

Borderline personality disorder symptoms

People with BPD exhibit most or all of the following symptoms:

  • frantic efforts to avoid real or imagined abandonment by friends or family;
  • unstable personal relationships that alternate between extreme idealization and devaluation;
  • distorted and unstable self-image;
  • impulsive, dangerous behaviour (e.g., overspending, substance abuse, unsafe sex, etc.);
  • self-harming behaviour, including suicidal threats and attempts;
  • periods of intense depression, irritability or anxiety, which can last for just a few hours to a several days;
  • chronic feelings of boredom and/or emptiness;
  • inappropriate, intense and uncontrollable anger, which is often followed by equally intense shame or guilt; and
  • dissociation and/or stress-related paranoia.

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Because BPD is a personality disorder, treatment options are limited. Behavioural therapies like cognitive behavioural therapy (CBT) and dialectical behavioural therapy (DBT) are the most effective treatment options for BPD. There are no medications designed specifically for BPD, but antidepressant, anti-anxiety and antipsychotic medications are often prescribed to BPD patients to address certain symptoms like depression, anxiety, dissociation, paranoia and intense anger. The benefit of these medications for people with BPD, however, remain unclear, and talk-therapy is often the first line of treatment for BPD.

How CBD can help

This is where CBD comes into the picture. When you ingest CBD, you ingest certain plant-derived cannabinoids, which act like the endocannabinoids the body produces naturally. The endocannabinoid system (ECS) produces endocannabinoids to regulate the body’s internal functions and control how we think, feel and react to things happening in the world around us.

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Endocannabinoids do not follow what is considered the typical path of a chemical synaptic signalling, which is for a neurotransmitter to flow from a presynaptic neuron to a postsynaptic neuron and bind to a specific receptor. Instead, endocannabinoids flow backward from postsynaptic neurons to presynaptic neurons in a process called retrograde inhibition.

Endocannabinoids are sent throughout the body by the ECS to achieve and maintain the body’s internal homeostasis, or balance, among all of is working parts. In many psychiatric disorders, symptomatic or episodic behaviours can be traced back to overactive neurons, which send too many neurotransmitters from presynapse to postsynapse and overload receptors.

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Since endocannabinoids follow the inverse of this process, they actually block and mediate the transfer of neurotransmitters to ensure the appropriate amount of neurotransmitters are being sent and binding to receptors. And, since the plant-derived cannabinoids that enter your body when you use CBD act like the endocannabinoids your body produces, they also work to mitigate the transfer of neurotransmitters and to combat overactive neural transfer associated with many of the BPD symptoms like anxiety, anger, impulsivity and even paranoia.

Among the endocannabinoid receptors that CBD activates are 5-HT1A serotonin receptors. Serotonin, informally known as the “happy chemical,” a chemical the body produces that’s important for mood regulation. People suffering from depression and anxiety, for instance, seem to exhibit lower levels of serotonin than do people who are not. People with BPD exhibit the same lowered serotonin levels. When CBD activates the 5-HT1A serotonin receptors, they bind to 5-HT serotonin neurotransmitters and increase serotonin production, which, in turn, combats the negative effects of depression and anxiety that come along with BPD.

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Products to use

CBD products made from or with hemp oil can also be beneficial to people struggling with BPD. Hemp oil is high in Omega-3 fatty acids, which could have an anti-inflammatory effect on the brain and help cognitive function. And many psychiatric disorders, including BPD, correlate with a deficiency in Omega-3 fatty acids in the body. Research on Omega-3 fatty acid supplementation found it to be an effective treatment method for both children and adults with BPD.

There is no single, miracle fix for BPD. Managing BPD is incredibly difficult and requires hours of therapy and hard work. With the right treatment combination, though, people with BPD can still lead wonderful and fulfilling lives. This article is not to suggest that CBD can replace existing BPD treatment, or to guarantee that CBD will even work for everyone with BPD who tries it.

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Everybody’s different, and so the way BPD manifests in different people and the way CBD affects different people is entirely relative to the individual. But CBD looks promising for BPD patients as a possible treatment option to supplement talk therapy and to target specific BPD symptoms that get in the way of everyday life.

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Targeting the Endocannabinoid System in Borderline Personality Disorder: Corticolimbic and Hypothalamic Perspectives

Borderline Personality Disorder (BPD) is a chronic debilitating psychiatric disorder characterized mainly by emotional instability, chaotic interpersonal relationships, cognitive disturbance (e.g., dissociation and suicidal thoughts) and maladaptive behaviors. BPD has a high rate of comorbidity with other mental disorders and a high burden on society. In this review, we focused on two compromised brain regions in BPD – the hypothalamus and the corticolimbic system, emphasizing the involvement and potential contribution of the endocannabinoid system (ECS) to improvement in symptoms and coping. The hypothalamus-regulated endocrine axes (hypothalamic pituitary – gonadal, thyroid & adrenal) have been found to be dysregulated in BPD. There is also substantial evidence for limbic system structural and functional changes in BPD, especially in the amygdala and hippocampus, including cortical regions within the corticolimbic system. Extensive expression of CB1 and CB2 receptors of the ECS has been found in limbic regions and the hypothalamus. This opens new windows of opportunity for treatment with cannabinoids such as cannabidiol (CBD) as no other pharmacological treatment has shown long-lasting improvement in the BPD population to date. This review aims to show the potential role of the ECS in BPD patients through their most affected brain regions, the hypothalamus and the corticolimbic system. The literature reviewed does not allow for general indications of treatment with CBD in BPD. However, there is enough knowledge to indicate a treatment ratio of a high level of CBD to a low level of THC. A randomized controlled trial investigating the efficacy of cannabinoid based treatments in BPD is warranted.

Keywords: Borderline personality disorder; cannabidiol; corticolimbic system; endocannabinoid system; hypothalamus; pharmacological treatment.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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Adverse effects of early stress…

Adverse effects of early stress exposure are a risk factor for the development…

Adverse effects of early stress exposure are a risk factor for the development of Borderline Personality Disorder. This depends on alterations in the hypothalamus and the corticolimbic system. The Endocannabinoid system may function as a modulator through receptor crosstalk in these brain regions.