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How to take cbd oil drops for sleep

The Best Way to Take CBD

With the legalization of regulated hemp production in the 2018 Farm Bill, CBD is being increasingly considered for conditions such as muscle aches & pain, anxiety, better sleep and even the treatment of certain types of seizures. Thinking this hemp-derived, natural remedy might be an option for you, but not sure where to start? Don’t worry, we’re here to help you find the best way to take CBD oil.

An Introduction to CBD

This introduction will look at the two most common ways to take CBD: oral and topical. Within these categories there are different delivery methods like capsules, tinctures, creams, and more. Don’t worry, we’ll walk you through this, it’s not as complex as it sounds.

Ready? Read on to learn what’s best way to take CBD oil for you.

Ingest It Orally

If you’ve never taken CBD before ingesting it is an easy place to start, You’re probably familiar with and maybe already using capsules and pills so taking CBD this way won’t feel too different. Plus monitoring dosage is easy with capsules since they come in pre-measured sizes.

Dosage is important and having a consistent concentration makes it easy to find out what works for you. Many customers start with our 25mg SoftGel capsule and slowly increase in 25mg increments until finding their ideal dosage. Capsules can take 45 minutes or longer to work itself into your system, and then last for several hours.

You can also just take CBD oil, which is called a tincture. Generally you consume this by placing it under your tongue and holding it there for up to a minute. Some people even use it in their food, or add a few drops to their favorite smoothie recipe similar to our Recovery Protein mix. Why choose a tincture? It’s easy to adjust your dose adding or subtracting a few drops, and it might work a little faster.

The third indigestible option is an edible such as a chewable gummie. These small, tasty morsels can be found in a variety of flavors and sizes yet still pack a CBD punch.

Oral products such as our SoftGels, tinctures and Gems have a systemic effect, meaning they work on your whole body. For people taking CBD for their anxiety, sleep issues, arthritis, or other whole-body issues this is great. But for those looking to help with a dodgy knee or tight back, a cream might be preferred.

Topical Application

If you’re mostly looking to try CBD for muscle aches and pains, a topical application (one you put on your body, not in your mouth) can be a good option. The value of topical applications is that they work quickly and target one area. Athletes love them for pain and injury.

We have a range of CBD products created just for topical use. Each one is packaged with other herbal and natural remedies to deliver a solution for different types of muscle and joint pain. Had a stak? Try our arnica formulation. Going out on a cold day and want to keep your knee pain at bay? We have a warming cream for you.

Isolate Vs Full Spectrum

You’ll notice that our products come in two versions, Isolate and Full Spectrum. The reason for this is that we believe, and science suggests, that we absorb things better in their natural form. For CBD, that means consuming the other terpenes and cannabinoids that exist in the hemp plant. This is what we give you in our Full Spectrum, or “whole plant” product. However, If you’re worried about a drug test at work the CBD only, THC-free Isolate is a safer bet as most of these tests look for THC. Neither of the products is designed to “get you high”, but we want to offer an option for everyone.

Ready to get started? Check out our shop to pick out the product that’s right for you and find the best way to take CBD oil today.

How to Take CBD Oil: CBD Drops, Coffees and Cocktails

So, you’ve read all about cannabidiol (or CBD as it’s more commonly known) and now you’re thinking of giving it a whirl. It makes sense. The food and wellness industries are buzzing about this natural chemical compound, which is said to help with anxiety, arthritis, pain relief, menopause symptoms and insomnia to name but a few.

You’ve decided you want to try it, so what’s next? When it comes to how to take CBD oil, you’re spoiled for choice. From tinctures and topicals to smoothies and coffee blends, there’s an overwhelming amount of options out there. Unsure where to start? That’s where we come in – here’s our CBD oil guide to help you decide how best to take CBD oil.

How to take CBD Oil?

While there are many ways to take CBD oil, it depends on the strength of the oil. With our 250mg CBD Oils (a great starting point), you put five CBD oil drops under your tongue and hold them there for 30-60 seconds, and do that three times a day. You can, however, freestyle, putting your drops into a smoothie, juice or even your morning cuppa. CBD is said to take the edge off coffee too.

Which brings us to…

9 Ways to Take CBD Oil at Home

1. In a tincture

In layman’s terms, a tincture is a concoction you take by dropper or spray straight into your mouth. You can take CBD oil by putting it directly under your tongue (that part of the mouth is a capillary-rich area and so the CBD will reach your bloodstream quicker). Try dropping a dose of CBD under your tongue and holding it there for a minute before swallowing.

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2. In a capsule

CBD oil also comes in a capsule form, which can be a good option for people who want to maintain a consistent amount of the compound in the body. However when CBD is ingested it passes through the digestive tract which means you might have to wait upwards of 30 minutes before experiencing any effect.

3. In a smoothie

Some blends of CBD oil can have a pungent, earthy taste. It’s not for everyone, which is why many people like to mask the flavour with other – more delicious – ingredients. Another way to take CBD is by adding half a teaspoon of CBD oil to your morning smoothie for a calm start to the day. If you’re after some smoothie inspo, head over to the 5 Best Self Care Smoothies With Hemp .

4. In coffee

If only there was a way to capture the energy of coffee without its associated jitters. Oh wait… there is! There are an increasing number of CBD coffee brands popping up, who claim that when coffee beans are infused with CBD, they take away the anxiety that caffeine consumption can cause. This makes the ‘up’ that your coffee gives you a little smoother; it takes the edge off. Or use a dairy-free milk that’s infused with CBD to easily control your dosage and allow you to continue using your favourite coffee blend.

5. In a salad dressing

Now we’re talking the same language, right? Try incorporating a little CBD oil into your daily cooking routine to get a bunch of health benefits without much effort at all. For a delicious and nutritious salad dressing, start with three to four tablespoons of olive oil, then add two teaspoons of CBD, the juice of half a fragrant lemon and salt and pepper. Here’s 5 hemp oil friendly recipes for starters.

6. In a vape pen

Okay so this one might sound a little scary, but vape pens are easy to use and can go undetected because they produce little smoke. The plus side of taking CBD in a vape pen is that when CBD is inhaled, it enters the lungs where it rapidly passes into the bloodstream. However, it’s important to note that the long-term safety of vaping is still unknown.

7. In sweet treats

The beauty of CBD is that it can basically be baked into anything, which is why you’ll find everything from cookies and brownies to gummies and caramel candies infused with it. Sweets are easy to take along with you in a bag on the go, while baked goods might need to be kept refrigerated to keep the CBD fresh (or just eat them quickly before they go off?).

8. In a topical rub or balm

In balm or rub form, CBD is often blended with fragrant coconut oil or beeswax, which makes it easy to spread on the skin (and makes your bod smell great too). When used topically, CBD can reach local targets, like sore muscles or joints. We’ve also heard it works wonders for period pain.

9. In a cocktail

If you’re feeling fancy go on the hunt for a CBD cocktail. We’ve heard reports that over in San Diego you can order The Mr Nice Guy – that’s a vodka and mezcal mixed drink that includes CBD. More proof, if any were needed, that CBD can be imbibed alongside any other food or drink, and that you’re going to be seeing a whole lot more of it soon.

How Much CBD Should I Take Each Day?

We always suggest starting the day with a few drops – it just sets the tone, you know? But you can top up throughout the day, no problem. Everyone will have an amount that works for them, just play around with it and see what feels good. We recommend starting with 5mg doses, 3 times per day and increasing your dosage incrementally over the course of a few weeks, ensuring you always stay below 70mg each day.

Check out our guide to CBD dosages for detailed advice.

Should I Refrigerate CBD Oil?

No, you shouldn’t. It’s best kept in a dark place like a pantry or cupboard so that it stays cool without getting too cold.

Should I Drink CBD Oil or Rub it Into My Skin?

Whichever you prefer! As outlined above, you can add CBD oil to a variety of different drinks or rub it into your skin as a topical balm. However, rubbing it into your skin tends to be better for sore joints or muscles.

What Does CBD Oil Under the Tongue Do?

This is one of the many ways the body can absorb CBD oil – as we mentioned above, your tongue is capillary-rich, meaning this method will allow the CBD to reach your bloodstream quickly.

How Long Does It Take for CBD Oil to Work on Joint Pain?

It depends on a variety of factors, such as how strong the CBD oil is (the stronger the concentration, the faster you will feel its effects) as well as how you are consuming it. For example, if you are taking CBD oil by placing a few drops under your tongue, it should take effect in around 15 to 45 minutes , while a topical application may take longer.

How Often Should I Take CBD Oil?

This varies from person to person and, when in doubt, you should always consult a doctor. However, we recommend starting with one of our 250mg bottles of CBD and taking five drops three times a day. After you begin to learn how this affects your body, you can better decide whether you should scale your dosage up or down (as long as you don’t exceed 70mg of CBD per day!).

Should I Take CBD Oil in the Morning or Evening?

Again, this is up to you and how CBD oil affects your body. People who find that CBD oil makes them feel energised, awake and clear-headed may prefer to take it in the mornings (or afternoons when they need a bit of a boost), while those who find that CBD oil helps them unwind and relax may prefer to take it in the evenings.

Can CBD Keep Me Awake at Night?

It can, but it probably won’t. While some people do feel that CBD oil makes them feel more alert, preliminary studies have shown that CBD oil is an effective way to treat insomnia.

Have we caught your attention? Now that you know how to take CBD oil, are you interested in trying it out for yourself? Check out our range of Pure CBD oils and start experimenting with your smoothies, baked goods and more!

Think You’ve Tried Everything for Your Sleep Issues? Enter CBD…

As editor-in-chief and co-founder of Miss Grass , an elevated lifestyle shop and publication for women and cannabis, Anna Duckworth has tried cannabis for everything from sex to cooking. And now, she’s sharing her cannabis knowledge with Well+Good. Today, she takes on a topic we’re all more than a little bit obsessed with over here: how to get a better sleep.

We are an exhausted nation: Roughly 70 million Americans suffer from chronic sleep disorders. And, considering lack of sleep can lead to mood and personality changes, we’re a cranky one, too. To put it simply, we’re tired of being tired and we’re looking for solutions.

Cannabis—CBD (cannabidiol, the non-psychoactive component of cannabis that’s cropping up in everything from lotions to lattes) in particular—is a tantalizing alternative to the typical Ambien prescription or medicine cabinet full of melatonin that, according to Elizabeth Cramer Ernst, nurse practitioner and owner of the medical marijuana clinic Hamptons Medi Spa, could provide significant relief for insomniacs. In recent studies, CBD has shown promising signs of being both an effective and safe way to get more zzz’s, although much more research needs to be done before definitive conclusions can be drawn.

Through the fog that comes with pulling unintended all-nighters night after night, however, it’s easy to lose sight of the fact that difficulty sleeping is very rarely just that. It’s almost certainly the result of an underlying condition. For many people, a lack of sleep comes down to anxiety—which, as we know, can be attributed to any number of external or internal factors from PTSD to financial strain. For others, sleepless nights are rooted in something physical, like chronic pain or restless leg syndrome. That’s why there’s truly no one-size-fits-all solution for sleep problems—including cannabis.

To find the best way for you to use cannabis or CBD oil for sleep, follow these three steps. And remember, it’s important to speak with your doctor before adding any new supplements to your routine.

1. Get to know your options

Cannabis remains illegal for recreational and/or medical use in many states. The good news for the canna-curious who live in a state that’s still under prohibition is that the passing of the Farm Bill in late 2018 federally legalized hemp, the cannabis plant that contains less than 0.3 percent of the psychoactive compound known as THC (tetrahydrocannabinol). And that means you can now legally access a whole range of hemp-derived cannabis products no matter where you live.

If you’re experienced with products that contain THC, know that some amount of the high-inducing compound can be effective in treating sleep disorders. But if you’re new to the cannabis party, it’s recommended to start with non-intoxicating cannabis products. These contain a high concentration of other active compounds—like the ever popular CBD (cannabidiol) or the lesser known but powerful sedative CBN (cannabinol)—that work by activating a network of receptors in the body known as the endocannabinoid system. Ultimately, your job is to test and try different products to find the dose just right for you.

2. Identify your main sleep issues

Everybody and every body is different. When you’re deciding on a course of treatment for sleep issues, first ask yourself this question: Do you have trouble falling asleep, staying asleep, or both?

According to Cramer Ernst, when using cannabis or CBD oil for sleep, there are a range of products from short-acting ones that can help you fall asleep fast to long-acting ones that can help you stay asleep, so you want to make sure you pick the one that addresses your particular ailment.

A vaporizer like the Her Highness Sleeping Beauty Vape Pen is considered short-acting because it takes effect in less than 10 minutes and is great for people who need help falling asleep. A tincture under the tongue, like Mineral’s Robyn for Sleep, is considered medium-acting because it takes 20 minutes to kick in and lasts between four and five hours. And then there are the edibles or capsules, like Plant People’s Be Calm Caps, which can take up to two hours to take effect but typically last between six and eight hours. (These long-acting ones are a great bet for people who can nod off easily but need help staying asleep.)

3. Integrate CBD into your sleep hygiene routine

So many of us stay up late working or scrolling through Instagram and don’t shut off our screens until it’s way too late (guilty!). Blue light from the screens has been proven to interrupt sleep dramatically and, experts say, should be avoided for up to four hours before bedtime. That’s not realistic for a lot of us, but even putting your phone down and turning off the TV an hour before you snuggle between the sheets can make a difference. It also helps to keep a regular sleep schedule so your body can start to anticipate the routine and begin shutting down without you having to force it.

One easy way to ease off the tech and begin regularizing your sleep habits is to create a bedtime ritual for yourself (with or without CBD—but, me being me, I vote for “with”). Practice meditation if that’s your jam, spritz your skin and bed with a soothing lavender spray, dim the lights, and give yourself a little massage with something like Apothecanna’s Calming Body Oil. One of my favorite tricks is to take a CBD bath with Vertly CBD Bath Salts or the CBD Bliss Bath Bomb, which Cramer Ernst says works by being absorbed into your skin. The mood-boosting power of a good soak plus CBD could be just the ticket to Dreamland you’ve been after.

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Hemp or cbd oil use for insect repellent

This Summer Try A Natural Insect Repellent

Knock on Hemp has produced an all-natural hemp seed oil that hydrates the skin and keeps the bugs away. It contains organic hemp seed oil and citronella, in a portable roll-on bottle. Thats it, all-natural! A perfect companion for a day outdoors playing sports or cooking out, and a must pack for those long outdoor excursions.

The oil isn’t sticky and is easily absorbed by the skin and hair, where it prevents water loss and introduces moisture. Hemp oil is an amazing source of fatty acids, omega 3 & 6, which balances the skin and reduces inflammation during those long active days. Citronella acts to repel the ever pesky insect that come along with being in nature. Together, they make the best companion for those who love the outdoors!

It’s going to be a long summer, let’s knock on hemp.

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You should consult a licensed health care professional before starting any dietary supplement, especially if you are pregnant or have any pre-existing injuries or medical conditions.

These products are not for use by or sale to persons under the age of 21. These products should be used only as directed on the label. Consult with your physician if pregnant or nursing. A Doctor’s advice should be sought before using hemp derived products. All Knock On Hemp product may have a +/-15% variance in potency.

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Hemp or cbd oil use for insect repellent

Cannabis as repellent and pesticide

John M. McPartland

53 Washington Street, Middlebury, VT 05753 USA

McPartland, John M. 1997. Cannabis as repellent and pesticide. Journal of the International Hemp Association 4(2): 87-92 Cannabis has been used as a pest repellent and pesticide in a variety of formulations. It has been planted as a companion crop to deter insects, nematodes, fungi, and weedy plants. Dried leaves and flowers have repelled or killed insects, mites, nematodes, and weeds. Plant extracts (either aqueous or polar organic solvent extracts) have killed or repelled insects, mites, nematodes, fungi, weedy plants, bacteria, and protozoans. Pure cannabinoids reportedly inhibit or kill bacteria, fungi, and insects. The validity of some of these reports is debated. Most of the scientific literature describes in vitro experiments, few studies concern field work. Utilizing left-over Cannabis leaves against pests appears to be a possible use for this harvest residue.

Certain plants with repellent and pesticidal properties have long been used to rid our crops, homes, and bodies of various pests (Grainge and Ahmed 1988). Famous examples include garlic (Allium sativum L.), castor (Ricinus communis L.), marigold (Tagetes patula L.), tansy (Tanacetum vulgare L.), neem (Azadirachta indica L.), pyrethrum (Chrysanthemum cinerariifolium (Trevir.) Vis.), tobacco (Nicotiana tabacum L.), and strychnine (Strychnos nux-vomica L.). Cannabis has also been used as a pest repellent and pesticide. This paper documents these uses from the scientific literature.

Materials and methods
The following data bases were searched with the keywords Cannabis, hemp, marijuana, cannabinoids: AGRICOLA (1990-1996), Biological and Agricultural Index (1964-1990), Review of Agricultural Entomology (1913-1996, a continuation of Review of Applied Entomology, Series A), Review of Plant Pathology (1922-1996, a continuation of Review of Applied Mycology), MEDLINE (1984-1994), and Index Medicus (1964-1994).
Cataloged holdings at the following libraries were searched for texts concerning allelopathy, biopesticides, botanical pesticides, and biological control: Dartmouth, Harvard, Michigan State University, National Agriculture Library, National Library of Medicine, Pennsylvania State University, Stanford University, University of Illinois, University of Missouri, University of Michigan, University of Pennsylvania, University of Vermont. All information regarding Cannabis was scanned for supporting citations, and antecedent sources were retrieved.

Cannabis has been utilized as a pest repellent or pesticide, in a variety of formulations. These formulations include dried plant parts, plant extracts or pure cannabinoids, as well as use of the genus as a “companion plant”.

Companion plants
Companion plants constitute a form of biological control – the use of living organisms to manage unwanted pests and disease organisms. Cannabis plants have been grown as companion plants alongside crops which require this protection. Riley (1885) noted that Cannabis sativa growing near cotton exerted a “protective influence” against cotton worms (Alabama argillacea, then called Aletia xylina). Similarly, hemp grown around vegetable fields safeguarded the fields from attack by a cabbage caterpillar, Pieris brassicae (Beling 1932); potato fields were protected against the potato beetle, Leptinotarsa decemlineata (Stratii 1976); wheat suffered less damage by the root maggot, Delia coarctata (Pakhomov and Potushanskii 1977); and root exudates of Cannabis repelled underground larvae of the European chafer Melolontha melolontha (Mateeva 1995). Some of these reports have been refuted in subsequent studies (Ziarkiewicz and Anasiewicz 1961, Mackiewicz 1962, Kurilov and Kukhta 1977).
Cannabis suppresses the growth of neighboring plants, whether they are noxious chickweed, Stellaria media (Stupnicka-Rodzynkiewicz 1970) or valuable crops such as lupine, beets, brassicas (Good 1953) and maize (Pandey and Mishra 1982). Hemp has been interplanted with potatoes to deter the potato blight fungus, Phytophthora infestans (Israel 1981).
Hemp has been rotated with potatoes to suppress the potato cyst nematode, Heterodera rostochiensis (Kir�yanova and Krall 1971). Hemp rotations also suppressed soil populations of the root knot nematode, Meloidogyne chitwoodi (Kok et al. 1994). Some cultivars of Cannabis are resistant to Meloidogyne hapla (de Meijer 1993). Scheifele et al. (1997) assessed the soil populations of several nematodes, before and after a hemp crop (using cultivars �Unico B� and �Kompolti�) in Ontario, Canada. The hemp crop suppressed soybean cyst nematodes (Heterodera glycine s), but increased the populations of spiral nematodes (Heliocotylenchus or Scutellonema species) and root knot nematodes (Meloidogyne incognita).
Mateeva (1995) studied an unspecified Meloidogyne on four different crops growing in Bulgarian soil. After 30 days, cucumber plants averaged 56 root knots per plant and 396 Meloidoygne larvae were found in the surrounding soil. Tomato plants averaged 42 root knots and 318 larvae, Cannabis plants averaged 5 root knots and 21 larvae, and marigolds averaged 1 root knot and no larvae. Mateeva concluded, “by including unfriendly plants in the rotation scheme with tomato and cucumber, it is possible to obtain a soil completely cleared from root knot nematodes.”

Dried plant parts
Grewal (1989) suppressed mushroom-eating nematodes (Aphelenchoides composticol a) by mixing 3 kg of dried Cannabis leaves into 137 kg of the compost used to cultivate edible Agaricus mushrooms. He also measured suppression of most mesophilic fungi in the mixture – especially Fusarium solani, Trichoderma viride, and Verticillium sp. Storage fungi such as Aspergillus spp. and Penicillium spp. demonstrated little suppression.
Dressing Cannabis seed cakes into soil successfully reduced populations of the soil nematode Meloidogyne incognita (Goswami and Vijayalakshmi 1986). Hemp straw mixed into soil depressed the growth of quack grass, Agropyron repens (Muminovic 1990), and rice, Oryza sativa (Vismal and Shukla 1970).
Dried leaves have been used to repel weevils in stored grain (Riley and Howard 1892, MacIndoo and Stevers 1924) and woolen cloths (Bouquet 1950). Scattering a 2 cm layer of dried, powdered leaves over piles of potatoes protected them from the tuber moth, Phthorimaea operculella, for up to 120 days (Kashyap et al. 1992). Khare et al. (1974) repelled Sitophilus oryzae weevils by mixing powdered Cannabis leaves into wheat, 1% w/w. Prakash et al. (1987) mixed dried leaves into rice, 2% w/w, to control S. oryzae weevils in the laboratory, but this dose failed to provide adequate protection under natural storage conditions (Prakash et al. 1982).
Dried leaves or juice squeezed from fresh leaves have removed vermin from the scalp and ears (Culpeper 1814, Indian Hemp Drugs Commission 1894), driven off bedbugs when placed under mattresses (Chopra et al. 1941), and killed larvae of the ticks Ixodes redikorzevi, Haemaphysalis punctats, Rhipicephalus rossicus, and Dermacentor marginatus (Reznik and Imbs 1965). In the latter study, powdered leaf material killed larvae in 10-12 minutes, whereas exposure to fresh, whole leaves killed larvae in 50 to 72 minutes.

Plant extracts
Plant extracts are a popular pesticide formulation. Extracts are produced by soaking fresh or dried plant material in a solvent. The plant material may be mashed or soaked whole. After an appropriate period of time, the solid material is filtered out, leaving the liquid extract. Aqueous extracts are the most popular. Polar organic solvents, such as alcohol or ether, are sometimes used to extract lipids from plant material.
Many reports describing the use of Cannabis extracts have omitted important information. For instance, the plant part harvested, and when it was harvested (what stage of the life cycle)? How much plant material (by weight) was soaked in the solvent (by volume)? How long was the material extracted, and at what temperature?

Inadequately described extracts have killed insect pests (Bouquet 1950, Abrol and Chopra 1963) and the mite Tetranychus urticae (Fenili and Pegazzano 1974). Metzger and Grant (1932) sprayed Japanese beetles with a United States Pharmacopoeia (U.S.P.) 80% ethanol extract, diluted to 1/64 strength. The spray weakly repelled adult beetles. (U.S.P. extracts are no longer available.)
Stratii (1976) boiled flowering hemp plants in water and sprayed the decoction on potato plants to kill the potato beetle (Leptinotarsa decemlineata). Jalees et al. (1993) killed mosquito larvae (Anopheles and Culex species) with an ethanol extract. Bajpai and Sharma (1992) sprayed a 20% w/v cold water extract of “bhang” on crop plants to reduce egg laying by Chilo partellus, a lepidopteran borer. A 20% w/v petroleum ether extract killed 40% of the borers, and this toxicity persisted for four days.

Mojumder et al. (1989) ground up 100 g of fresh Cannabis leaves in 25 ml water and filtered it through muslin cloth. This extract killed J2-stage juvenile nematodes (Heterodera cajan i) in 6 hours. A 5% solution of the extract also killed nematodes after 24 hours. Haseeb et al. (1978) macerated 10 g of either roots or above-ground shoots in a Waring blender for 10 seconds and extracted the mash for 24 hours in 75 ml distilled water. The shoot extract did slightly better than the root extract, killing a variety of plant-pathogenic nematodes (Hoplolaimus indicus, Rotylenchulus reniformis, Tylenchorynchus brassi-ca e). When diluted to 10% of its original strength, the root extract caused greater mortality than the shoot extract.

Ferenczy et al. (1958) extracted an Italian hemp (cultivar �Bologniensis�) in “organic solvents and alkali”. The extract did not inhibit in vitro growth of yeasts (Saccharomyces, Rodotorula, Hansenula spp.) or filamentous fungi (Aspergillus, Penicillium spp.). Ethanol extracts of leaves inhibited spore germination of Ustilago species (Misra and Dixit 1979, Singh and Pathak 1984) and Neovossia indica (Gupta and Singh 1983).
Upandhyaya and Gupta (1989) inhibited Curvularia growth on petri plates with an aqueous extract, prepared by extracting 10 g of Cannabis leaves in 100 ml cold water. Greater inhibition was achieved with an ethanol extract, mixing 5 g leaves in 100 ml of 80% ethanol. In a similar experiment, Kaushal and Paul (1989) inhibited growth of Colletotrichum truncatum, but not Septoria glycines or Ascochyta phaseolorum. Neither aqueous nor ethanol extracts inhibited growth of the human pathogen Trichophyton rubrum or the opportunistic pathogen Aspergillus niger (Gupta and Banerjee 1972).
Pandey (1982) crushed 10 g of leaves in 100 ml water and filtered the mash with filter paper. A 40% solution of the extract inhibited 25 different species of fungi that infested stored seeds of finger millet (Eleusine cora-cana L.), including species of Aspergillus, Penicillium, Cladosporium, Drechslera, Fusarium, Cephalosporium, Rhizopus, Mucor and Curvularia. An aqueous extract of hemp protected pine seedlings from a disease caused by an unnamed Fusarium species (Vysots�kyi 1962).

In vitro experiments show that whole seeds inhibited growth of gram (+) Bacillus cereus (Ferenczy 1956). Subsequent research by Ferenczy et al. (1958) disclosed that the flowering tops and “resinous organs” of hemp inhibited growth of gram (+) bacteria (B. cereus, B. subtilis, Staphylococcus aureu s), but did not affect gram (-) bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi, Shigella species). Ferenczy and coworkers concluded, “the antibacterial activity is ever proportionate to the intensity of the hashish reaction [potency].”
In contrast, Radosevic et al. (1962) stated, “antibiotic activity decreases with. the increase of hashish activity.” They examined resins extracted from 11 different varieties, including tropical hashish varieties (from Brazil) and temperate hemp varieties (from several European countries and Canada) and assayed the effects of these ethanol extracts (using 60 mg Cannabis resin per 1 ml ethanol) on growth of B. subtilis. concluding that cannabidiolic acid was the primary antibiotic agent.
Ethanol extracts of Cannabis tissue cultures inhibited gram (+) S. aureus, Bacillus megaterium, and gram (-) Escherichia coli, but did not affect gram (-) Pseudomonas aeruginosa (Veliky and Genest 1972). In a subsequent study (Veliky and Latta 1974), thin layer chromatography located two active Cannabis ingredients at R f 0.87 and R f 0.61 on the chromatography plates.
Soviet agronomists sprayed an aqueous extract of hemp and wild hemp, called “cansatine 4” or “konsatin,” on potato crops and tomato seeds to kill plant-pathogenic bacteria (Zelepukha 1960). The extract worked against gram (+) Corynebacterium species and gram (-) Pseudomonas and Agrobacterium species (Bel�tyukova 1962). Aqueous extracts also inhibit gram (-) Erwinia carotovora and other bacteria causing soft rot of potatoes (Vijai et al. 1993).

Srivastava and Das (1974) prepared an aqueous extract by crushing 100 g of Cannabis leaves and stems in 10 ml of water at 30 o C. The extract inhibited seed germination of purple nut sedge, Cyperus rotundus. Stupnicka-Rodzynkiewicz (1970) used aqueous extracts to inhibit weed seed germination of false chamomile (Matricaria recutit a) and lemon grass (Lepidium sativum).

Nok et al. (1994) prepared a seed extract by crushing 10 g of dried seeds, mixing the powder in 200 ml petroleum ether, stirring continuously for 1 hour, filtering, and then washing the filtrate with 100 ml portions of N/10 NaOH. The ether extract had a profound trypanocidal effect on Trypanosoma brucei tested in vitro. Mice infected by T. brucei were injected with the extract (50 mg/kg/d) and cured in 5 days.

Pure cannabinoids
Cannabinoids are a family of C 21 terpenophenolic compounds uniquely produced by Cannabis (Turner et al. 1980). Some studies reportedly working with pure cannabinoids are probably erroneous, such as those working with aqueous extracts (Bajpai and Sharma 1992). Aqueous extracts should contain little cannabinoid, as these compounds are not very water-soluble. In a study using ethanol extracts, Veliky and Latta (1974) located two zones of bacterial inhibition at R f 0.87 and R f 0.61. These R f values did not correspond to the tetrahydrocannabinol (THC) and cannabidiol (CBD) values they had determined in a previous study (Veliky and Genest 1972). Nok et al. (1994) assumed that the ether extract they successfully tested against Trypanosoma brucei contained cannabinoids. But they had extracted Cannabis seeds, which do not contain cannabinoids except sporadically as contaminants from bract debris clinging to the outside of the seeds (M�th� and B�csa 1995).

Schultz and Haffner (1959) inhibited gram (+) S. aureus and B. subtilis with a dilute solution (1:100,000) of CBD. Inhibition of gram (-) E. coli required a much stronger solution (1:1,000) of CBD. Gal et al. (1969) tested cannabinolic acid as a fruit juice preservative and reported its effectiveness against gram (+) B. cereus, Lactobacillus plantarum, and Leuconostoc mesenteroides. Klingeren and Ham (1976) inhibited gram (+) S. aureus, Streptococcus pyongenes and S. faecalis growing in broth with THC and CBD at minimum inhibitory concentrations of 1-5 �g/ml. Both compounds were also bactericidal. Gram (-) organisms (E. coli, Salmonella typhi, Proteus vulgari s) were resistant to THC and CBD at the highest concentration tested (100 �g/ml).

Flowering tops, where cannabinoid concentrations are highest, are less susceptible to some fungal pathogens (Charles and Jenkins 1914, McPartland 1983). McPartland (1984) extracted flowering tops with petroleum ether, then eluted the extract into its separate components with thin-layer chromatography (using silica gel on glass plates). He sprayed eluted plates with spores of Phomopsis ganjae suspended in a nutrient solution. Spore germination was inhibited by three components of the extract, located by thin-layer chromatography at R f 0, R f 0.20 and R f 0.68. The latter two zones consisted of CBD and THC, respectively.
Dahiya and Jain (1977) extracted THC and CBD using adsorption column chromatography, (affirming correct identification with thin-layer chromatography and gas chromatography), and assayed effects of these cannabinoids against in vitro growth of 18 fungi. Generally, THC inhibited human pathogens (e.g., Microsporium and Trichophyton species) more than CBD. Conversely, CBD inhibited plant pathogens (e.g., Alternaria alternata, Curvularia lunata, Fusarium solani, Trichothecium rose-u m) more than THC. Two fungi were completely resistant to THC and CBD – Aspergillus niger and Penicillium chrysogenum. Interestingly, these two species are frequently isolated from moldy marijuana (McPartland and Pruitt 1997).

Rothschild et al. (1977) conducted fascinating experiments with tiger moths (Arctia caja). Tiger moth caterpillars, like monarch butterfly caterpillars, feed on poisonous plants and store plant poisons in their exoskeleton. The stored poisons repel caterpillar predators, providing an evolutionary advantage. Rothschild et al. (1977) fed the caterpillars a Mexican plant rich in THC. The caterpillars stored some of the THC in their exoskeleton. But caterpillars fed a pure diet of high-THC plants were stunted and did not survive beyond the third instar. Nevertheless, Tiger moth caterpillars preferred eating the deadly high-THC varieties to low-THC plants. Rothschild noted, “. should these compounds [cannabinoids] exert a fatal fascination for tiger caterpillars, it suggests another subtle system of insect control by plants.”

Research demonstrates the moderate efficacy of Cannabis as a repellent crop or botanical pesticide. We are faced, however, with a paradox: some of the pests controlled by Cannabis are also known to attack hemp and marijuana crops. If Cannabis serves as an effective pesticide, then how can the pests infesting Cannabis survive? Perhaps they intersperse marijuana meals with less-toxic lunches on other plants. Caterpillars of Spilosoma obliqua, for instance, eat Cannabis leaves and female flowers (Nair and Ponnappa 1974). But when Deshmukh et al. (1979) force-fed S. obliqua caterpillars a pure Cannabis diet, they died after 20 days.
Obviously Cannabis is not a cure-all poison; a highly toxic botanical insecticide could not also serve as a human medicament, as Cannabis does (Clarke and Pate 1994, McPartland and Pruitt 1997). Indeed, plants that are never infested by insects are considered dangerous by traditional Ayurvedic healers in India (Thatte et al. 1993). What active ingredients in Cannabis work so well against pests? Is THC the primary pesticidal ingredient? Characterizing THC as a powerful pesticide would put it in the same category as nicotine, which is highly toxic to arthropods, fish, birds, and mammals. Although THC and other cannabinoids have proven activity against bacteria and fungi, their activity against insects is questionable. The study by Rothschild et al. (1977) assumed the sole difference between high-THC and low-THC plants was the level of THC. Recent work has shown that high-THC plants produce 3 to 6 times more limonene and pinenes than most low-THC plants (Mediavilla and Steinemann 1997). Cannabinoids are very safe to mammals. The oral LD 50 of THC in mice is greater than 21,600 mg/kg (Loewe 1946), safer than neem oil.
Cannabinoids probably play a small role in Cannabi s� pesticidal activity, but aqueous Cannabis extracts work very well as pesticides, even if they contain little cannabinoid. Cannabis contains more than 400 chemicals (Turner et al. 1980). Their leaf glands ooze dozens of volatile compounds, such as terpenes, ketones, and esters which produce the characteristic odor of the plant (Ross and ElSohly 1996). The limonene and several pinenes which comprise over 75% of volatiles detected in the “headspace” atmosphere surrounding Cannabis leaves (Hood et al. 1973, Ross and ElSohly 1996) are powerful insect repellents. Methyl ketones present in Cannabis (Turner et al. 1980) also repel many leaf-eating insects (Kashyap et al. 1991). A synergistic combination of these many compounds may serve as the “active ingredient” in Cannabis.

CBD balm for mosquito bites

The list of positive effects of CBD cannabinoids grows longer by the day. By applying CBD resin or drops under the skin, you will more successfully alleviate problems with insomnia, stress and chronic illnesses. When CBD is applied to the skin, it gets to work by focusing on balance, promotes cellular communication and soothes inflammatory processes. It is this latter activity that is important when talking about CBD cannabinoids and insect bites.

Why do mosquitoes bite?

Today it is relatively well known that it is only female mosquitoes that bite. They bite in order to be able to suck our blood which is rich in proteins that are crucial for the successful production and development of mosquito eggs. Since mosquitoes never know when they will successfully come into contact with a potential human host, they take their ‘meals’ very seriously! In just one feeding session they can consume up to three-times their bodyweight in human blood.

A few more interesting facts about mosquitoes

There are around 3,500 different types of mosquitoes throughout the world. Despite their short lifespan (2 months), mosquitoes have one of the longest traditions in the insect world. Scientists date their beginnings to the period of dinosaurs; it is their small size and adaptability that have enabled the species to survive until today. Mosquitoes don’t bite just humans, they are also partial to the blood of various animals, such as frogs and birds. Did you know that mosquitoes are just crazy about CO2? Exhaled carbon dioxide is the reason that mosquitoes discover even the smallest slit in a window or hole in a mosquito net. Practice makes perfect and mosquitoes have had a huge amount of time to perfect their abilities! They now have a special organ for detecting the presence of carbon dioxide, which they are able to detect at distances of up to 50 metres.

What happens when we are bitten by a mosquito?

The main reason that mosquitoes are always on the list of ‘unwanted guests’ is due to the annoying itching that occurs in the place where we have been bitten. The itching occurs due to an inflammation which is caused intentionally by our immune systems. Itching, redness, and swelling are the effects of the insect poison reacting against the antibodies that are responsible for fighting poison in our body.

Why does CBD sooth skin after a mosquito bite?

When we are bitten by a mosquito an inflammation occurs in our bodies which appears as red, swollen and itchy skin. CBD cannabinoids have a strong anti-inflammatory effect and are therefore effective in reducing, or stopping, the itching which occurs after a mosquito bite. CBD balm that is rubbed into the effective area also works on the skin’s endocannabinoid system – this means that it accelerates communication between cells and the skin’s epidermis and alleviates excessive reactions which occur after a bite.

The results of applying Therapeutic CBD Skin Balm to the affected skin are:

  • Calming of itching
  • Calming of irritation
  • Reduction of local inflammation

What are the benefits of CBD cannabinoids over other remedies for insect bite?

  • CBD ointment is acquired from the green part of industrial hemp type Cannabis Sativa and is 100% natural
  • There are no side-effects (it cares for and nourishes skin)
  • There are no restrictions on use (CBD ointment can be used on any areas of the skin, as many times as required)
  • It is safe, healthy and effective
  • It is suitable for infants, pregnant women, and nursing mothers

Therapeutic CBD balm

Concentrated CBD treatment balm tackles the toughest symptoms of atopic skin, alleviates skin reactions and soothes eczema flare-ups. Reach for it when skin needs fast-acting help for inflamed, reddened and itchy conditions. It provides intense relief and unique nourishing care. Ingredients: High concentration of CBD extract is a powerful anti-inflammatory and skin-soothing properties. Hemp seed oil, rich in essential fatty acids omega 3 & 6, Vitamin E and minerals – the building blocks of healthy skin. Calendula, shea and mango butter soothe and nurture.

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Benfits of cbd oil for dogs with seizures

16 Best CBD Oils for Dogs with Seizures

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There are many things that can cause seizures in dogs, from health problems to toxins. CBD oil has been shown to be effective in reducing seizures and related symptoms in some dogs, making it a viable treatment option for pet owners.

Here we will take a look at 16 of the best CBD oils for dogs with seizures, based on quality, potency, and price.

4. Cannanine™ Ultra-Premium Broad Spectrum Hemp CBD Oil

5. EVN CBD Tincture

6. Honest Paws CBD

7. Holistapet CBD

8. cbdMD Paw CBD

9. Innovet CBD Oil

10. NuLeaf Naturals Pet CBD

11. Green Roads Pet CBD Oil

12. Charlotte’s Web Hemp Extract

13. Joy Organics

14. PureKana Pure Pets CBD

15. Medterra Pets CBD Tincture

16. Cornbread Hemp CBD Oil for Pets

What are seizures, and why are they so bad?

Seizure is the term for a sudden change in behavior due to abnormal electrical activity in the brain. Seizures can present themselves as twitching, trembling, drooling, confusion, loss of balance or consciousness, convulsions, involuntary urination or defecation, and even a complete loss of consciousness.

While some seizures might be no big deal, others can last for minutes and lead to a loss of coordination or other problems for hours after the seizure is over. Seizures should be taken seriously, as they may indicate serious health problems such as epilepsy, brain tumors, liver disease, organ failure, or rabies.

Why do dogs seize?

Ten million dogs in the US alone suffer from seizures, with various causes resulting in different severities. Dogs may seize because of poisoning from food, diseases like distemper, old age, liver disease, kidney failure, injury to the brain or spine, brain tumors, a stroke, or a hereditary condition such as epilepsy.

How will I know if my dog is having a seizure?

If your dog is having a seizure you might notice some of the following: rapid body movements, head or eye twitching, foaming at the mouth, whimpering, whining or growling, loss of consciousness, or responsiveness to stimuli such as pain.

Seizures can last anywhere from a few seconds up to several minutes and may cause your dog to urinate or defecate involuntarily.

What should I do if my dog has a seizure?

If you notice that your dog is having a seizure, try to determine how long it lasts and take note of the time and any changes to your dog’s behavior after the seizure is over. If it seems like your dog does not regain consciousness within a few minutes, take them to the nearest emergency veterinarian as soon as possible.

If you can do so safely, try to keep other animals and people away from your seizing dog and stay with them until the seizure ends. Do not place any objects or your hands in their mouth, as they may snap at you by accident. If your dog appears to be choking, perform the Heimlich maneuver.

You should keep a close eye on your dog for the next 24 hours after a seizure occurs, as dogs are more likely to have another seizure within a day or two of the first one. While many dogs will recover from seizures on their own, some may have severe consequences and need medical attention or immediate treatment.

Dogs with epilepsy often experience more seizures than dogs who suffer from other conditions, so it is important to watch your dog for any changes in behavior that could indicate a seizure.

How can CBD help my dog’s seizures?

CBD may be able to help with your dog’s seizures in several ways. The first is by reducing the number of seizures your dog experiences if they have epilepsy or another condition that leads to repeated seizures.

Secondly, CBD may be able to reduce the severity or length of these seizures. The reason for this is that CBD may be able to regulate harmful electrical activity in a dog’s brain that leads to seizures and reduce the amount of stress or injury caused by uncontrolled neurochemical exchanges.

Finally, CBD may have a positive effect on your dog’s mood during and after a seizure by regulating neurotransmitter levels in the brain. Not all CBD is created equally, so make sure you purchase a high-quality CBD extract to ensure its safety and effectiveness. And, of course, talk to your veterinarian to make sure CBD is right for your dog.

Will CBD oil treat seizures in dogs?

As with any sort of treatment, CBD oil will help some dogs more than others. However, it is important to note that CBD oil is not a cure for seizures, but rather a supplement that can be used in conjunction with other medications and treatments.

Many pet owners report good results using CBD oils alongside anticonvulsant medications.

What are some other medications a dog with seizures may have to take?

Some other medications a dog with seizures may have to take include:

· Phenobarbital: A barbiturate that is used to control seizures in dogs.

· Potassium bromide: Also used to control seizures, potassium bromide can be used in combination with phenobarbital or on its own.

· Zonisamide: Another anticonvulsant that is sometimes prescribed to dogs with seizures.

· Benzodiazepines: Benzodiazepines such as diazepam and midazolam can be used to relieve anxiety during a seizure.

· Antidepressants: Amitriptyline is one type of antidepressant that may be prescribed to dogs who suffer from seizures because it has the ability to lessen the frequency and severity of seizures in some cases.

What are the different types of CBD Oil for Dogs?

CBD oils are generally either tinctures, which are drops placed under the tongue, or topical ointments that can be applied directly to areas of pain. Most CBD oil for dogs comes in a tincture form that can be added to food or given directly to your pet by mouth.

How long does CBD Oil take to work for seizures in dogs?

CBD oil can take anywhere from a few minutes to a few days to be effective. It is best to give the CBD oil for at least two weeks before giving up on it if you are not seeing results. Like any supplement, your dog may respond better or worse than other dogs, so adjusting dosage accordingly may help speed up the process of seeing whether CBD oil is effective.

How Should you dose CBD Oil for Dogs?

Since every dog is different, start with a low dose of CBD oil and then slowly increase until your pet responds positively. The standard dosage for dogs is between 10 mg-30 mg per pound of body weight, given twice daily. However, this may be adjusted depending on the severity of your dog’s seizures.

What are the best CBD oils for dogs with seizures?

We’ve compiled a list of the best CBD oils for dogs with seizures to help you make an educated choice of which CBD oil to start with:

1. Penguin CBD Oil

Image courtesy Penguin CBD

Your pup will feel the love with this CBD oil. Made from non-GMO hemp, it’s grown right in Oregon, USA. Every batch goes through rigorous testing for quality assurance so you can be sure that your dog will feel better from their seizure symptoms after taking this product.

2. Everest Full-Spectrum CBD Oil

Image courtesy Everest

We all know how much our dogs love to play. But in the case of those suffering from seizures, they can’t always get up and down without assistance- which is why we’ve included Everest’s potent CBD oils that provide similar benefits as cannabis but without any psychoactive effects.

3. Verma Farms Salmon CBD Oil

Image courtesy Verma Farms

Verma Farms offers a variety of products that promote health and wellness. From pet tinctures to skin serums, they have something for every animal lover.

The company is well-known among many people in this industry so if you’re looking into getting your hands on some high-quality treats then Verma Farms will be sure not disappoint with its unbeatable prices.

4. Cannanine™ Ultra-Premium Broad Spectrum Hemp CBD Oil

Image courtesy Cannanine

This hemp oil with CBD for dogs and cats is a full-spectrum extract that offers unparalleled botanical support for your dog’s health and wellness, with no THC. Cannanines pet tinctures can ease many common problems including allergies and mobility issues.

5. EVN CBD Tincture

Image courtesy EVN

EVN’s natural tinctures are perfect because they don’t contain any THC. What does this mean? It means your furry friend will never feel sick or high; just calm headedness with no side effects whatsoever. And if their diet isn’t enough already, then try out one the vegan dog treats made by EVN, too.

6. Honest Paws CBD

Image courtesy Honest Paws

The best way to find the right CBD oil for your dog is by contacting Honest Paws. The company offers a high-quality tincture that promotes calmness and comes with 30 days of satisfaction guaranteed or you get all of your money back.

7. Holistapet CBD

Image courtesy Holistapet

Holistapet’s CBD Tincture is the perfect solution for pets with seizures. It lacks THC, so there are no psychoactive or hallucinogenic effects. The product comes in different strengths depending on your pet’s weight: 150 mg version designed to serve animals under 20 pounds; 300 mg for dogs weighing between 20 and 60 lbs., 600 mg intended primarily towards larger breeds (those over 160 lbs).

8. cbdMD Paw CBD

Image courtesy cbdMD

Give your dog a happy and healthy life with the help of CBD oil from cbdMD. The high-quality ingredients in these pet tinctures will ease their seizure symptoms while providing optimal relief for any type or size animal.

9. Innovet CBD Oil

Image courtesy Innovet

Innovet has created a CBD tincture for dogs that not only provides joint relief and internal balance but also helps dogs who have seizures feel more relaxed. The unique formulated full spectrum golden hemp oil is sourced from organically grown plants to ensure quality standards are met in addition with third party lab results confirming its safety.

10. NuLeaf Naturals Pet CBD

Image courtesy NuLeaf Naturals

NuLeaf Naturals’ full spectrum CBD oil for pets is made with high-quality ingredients that will help your furry friend feel his or her best. Whole plant extract offers the cannabinoids and terpenes found in both human medication as well as animal wellness, making it beneficial to everyone.

11. Green Roads Pet CBD Oil

Image courtesy Green Roads

With a wide selection of ready-to-drink pet CBD tinctures, Green Roads is the perfect solution for your furry friend’s needs. All ingredients are sourced without any harmful chemicals or pesticides so you can rest assured that they’re safe too. These delicious tasting treats also help strengthen digestion by combining an MCT oil base with cannabidiol (CBD).

12. Charlotte’s Web Hemp Extract

Image courtesy Charlotte’s Web

Charlotte’s Web has formulated a high-quality tincture that is designed just for dogs. This CBD contains whole plant hemp extract, which includes the full spectrum of cannabinoids from US grown plants without any flavor added.

13. Joy Organics

Image courtesy Joy Organics

With the release of their premium USDA organic CBD pet tincture, Joy Organics has created a product for dogs and cats that will help support your pup’s health with powerful terpenes & cannabinoids. The broad-spectrum extract contains everything you need to calm down or energize any furry friend in need.

14. PureKana Pure Pets CBD

Image courtesy PureKana

Your pup can’t resist this bacon-flavored CBD oil. PureKana’s pet drops are also made with full-spectrum hemp seeds. Not only does it have an excellent flavor but this oil provides 500 mg worth for each bottle you buy so Fido can feel better than ever before.

15. Medterra Pets CBD Tincture

Image courtesy Medterra

Your furry friend will feel satisfied and happy with Medterra’s CBD pet tinctures. These organic, all-natural flavors are perfect for them.

16. Cornbread Hemp CBD Oil for Pets

Image courtesy Cornbread Hemp

Your furry friend is going to love this delicious, organic CBD oil from Cornbread Hemp. It comes in the form of a vegan corn dog flavoring.

What are the other benefits of CBD Oil for Dogs?

CBD has many potential benefits when it comes to dogs, including pain relief, reduced anxiety, better moods after surgery or illness, and even increased energy. CBD oil is also known to help with certain types of issues such as skin allergies, arthritis, and other chronic pains.

How does CBD oil make a dog feel?

CBD is non-psychoactive, meaning it does not get your dog “high.” You will still be able to tell if your dog has received treatment by the reduction in symptoms such as seizures, pain, or anxiety. CBD oil is a safe and effective treatment for many canine conditions, and can also help to improve your dog’s quality of life.

Are there any side effects of CBD oils for dogs with seizures?

CBD oil is non-toxic and side effects are rare. There have not yet been any reported cases of toxicity or death resulting from CBD oil usage for dogs, even in large doses. While some dogs may experience mild fatigue or dry mouth, these effects are temporary and should not be cause for alarm.

Do vets recommend CBD oil for dogs?

A wide range of veterinarians and veterinary specialists now recommend CBD oil for dogs, as the benefits far outweigh the risks. Veterinarians are able to prescribe either tinctures or topical oils and discuss dosage with pet owners, but they cannot legally provide their clients with recommendations on how much to use for their individual dogs without doing extra research first.

Can you give too much CBD to a dog?

Since CBD oil for dogs is non-toxic, there is no risk of giving an unsafe amount. The biggest risk when it comes to overdosing on CBD oil in dogs comes down to the other ingredients in the oil blend. If your dog has an adverse reaction to certain supplements or medications, it is possible that they may react negatively with CBD oil too.

Do you need a medical marijuana card to buy CBD Oil for dogs?

No, there is no requirement for a medical marijuana card in order to purchase and use CBD oil for your dog. CBD oil is legal in all 50 states and has been found not to have any psychoactive effects when taken at the recommended dosage levels. There is no chance of your dog becoming high from CBD oil, and it is perfectly safe to use.

What do I need to know before giving CBD to my Dog?

CBD oil can be used to treat a variety of conditions in dogs, but it may not work for every dog. You will need to do some research first before you start administering CBD treatment on your own.

Again, you should always consult with a veterinarian before giving your dog CBD oil for seizures. Some dogs may experience adverse reactions to CBD oil if they are taking other medications or supplements.

It is important to do your research before starting CBD treatment and to start with a low dose to see how your dog reacts. Some dogs may not respond to CBD oil immediately and will require a dosage increase before they experience relief.

Be knowledgeable about the benefits of CBD oil for dogs and how it affects them so that you can track your dog’s progress during treatment. Stay up-to-date on research and information from reputable organizations and sources.

Can CBD oil make seizures worse?

CBD oil does not appear to make seizures any worse, and can even reduce the frequency of seizures in certain dogs. However, if your dog is taking another medication for seizures, such as phenobarbital, you should consult with a veterinarian before adding CBD oil to their treatment regimen.

Never give your dog two medications that contain the same ingredient at the same time, as this can lead to overdose symptoms such as excessive drowsiness or sedation.

How long does CBD Oil last in a dog’s system?

There is no exact timeframe for how long CBD will remain active in your dog’s system after they ingest it. It depends on the dosage that was given, as well as your dog’s weight and metabolism. A ballpark estimate can be obtained by multiplying your dog’s dosage by 6-12 hours.

Is Hemp Oil & CBD oil the same?

Although CBD oil and hemp oil both come from the same plant, they are very different. Hemp oil is made by cold-pressing hemp seeds and extracting the oil with low heat. CBD oil uses a special extraction process that involves more advanced methods of filtering and heating to produce higher purity oils.

Can you give a dog CBD every day?

Since CBD oil is non-toxic, you can safely give your dog CBD every day. However, you will want to make sure that the CBD oil is made using organic hemp plants, as this will ensure that there are no harmful chemicals or pesticides in the tincture. Never use essential oils on pets unless prescribed by a veterinarian first.

CBD Oil For Treating Seizures & Epilepsy In Dogs

Dog seizures and epilepsy in general are scary for anyone to witness, but when it is your dog, it is emotionally wrecking to watch. It leaves you feeling helpless and distraught, which is the opposite of how we like to feel when it comes to our babies. We want them to know they are safe with us and that we will take care of them, no matter what.

Dogs seizures and epilepsy in dogs can be difficult to treat because there are many possible causes for them. CBD is a discovery that has proven to help with seizures in humans. It’s not a big jump to think that it could help pets as well. Many people have been using CBD oil as a natural therapy for dog seizures of all types with promising results.

What is CBD Oil?

Canine CBD oil is an extracted from hemp plants. It is one of over 100 cannabinoids found in cannabis plants (hemp is in the cannabis family). CBD is short for cannabidiol. Cannabidiol, or CBD, is equally as familiar to most people as tetrahydrocannabinol THC is.

Tetrahydrocannabinol THC is the psychoactive compound found in marijuana that is responsible for the head high experienced from using it. But CBD products derived from a hemp plant are free of toxins, psychoactive properties, and other high related side effects. Hemp is free from THC because the hemp plant itself contains less than 0.3% of THC in the first place.

With such a small amount of THC, hemp is considered free from it because this value is considered a trace amount. All canine CBD products are free of low quality ingredients and any related toxins.

Luckily, CBD doesn’t have that impact on the brain, but it still has many of the same medicinal uses as marijuana. Dogs, however, cannot have tetrahydrocannabinol. It’s toxic for them, so you should avoid THC products. High quality CBD, however, is safe for them. So far, there have been no documented ill-effects from the use of CBD for dogs, or humans for that matter.

The Many Treatment Options for Dogs with Epilepsy

Before we dive into the benefits of CBD oil for dog seizures, let’s explore medications used to treat dog seizures that aren’t CBD products. CBD oils are an all natural way of helping dogs with seizures and seizure control but there are many other treatment options for dog seizures, including:

  • Potassium bromide
  • Anticonvulsant drugs
  • Treatment for pain relief
  • Phenobarbital
  • Diazepam

What Are the Benefits of CBD Oil for Dog Seizures?

So, if there are already many different treatment options for seizures in dogs, then why do people turn to CBD oil for dog seizures? Well, it all comes down to the way CBD oil offers numerous benefits, the first of which is the fact that CBD products don’t contain any unnatural ingredients. In other words, everything about CBD is natural.

CBD comes from a hemp plant, which is part of the cannabis plant family. However, hemp is not the same as the cannabis everyone assumes it is. While cannabis can get you high, a hemp plant is different because it doesn’t have enough THC to cause those psychotropic side effects. Instead, hemp can be used to treat pain from a head injury, offer relief from pain, and provide you with a way to manage your dog’s symptoms from seizures in dogs.

Plus, dog owners should know that a dogs body is already equipped with the internal processes that allow them to consume CBD oils for dog seizures. In your dog’s body, there are what’s known as CB1 receptors which are responsible for breaking down CBD molecules. They play a role in making CBD dog effective for seizures in dogs and helping dogs with seizures find relief from seizure discomfort.

CB1 receptors are a natural receptor in the body. But what is a receptor? Essentially, they are a main player in the overall functionality of the brain. They make it possible for compounds, molecules, and other elements that pass through the brain-blood barrier to be broken down effectively. There are numerous different kinds of receptors in the brain, and they all serve their own unique function.

Basically, these receptors are part of the endocannabinoid system, which is similar to the nervous system. However, the main difference is the purpose that these systems are designed for, with the endocannabinoid receptor being responsible for breaking down CBD and the nervous system existing for the purpose of regulating your dog’s homeostasis.

Is CBD Legal for Dogs?

One question that pops up all the time asks if cannabidiol is safe in the first place. Well, thanks to the signing of the Farm Bill of 2018, CBD has been legal, coast to coast, in the USA since January 1st, 2019. Before that, there had been an easing of regulations. However, before then, CBD still wasn’t legal worldwide. Did you know that one of the first places to legalize CBD is Colorado State? Many other US states followed suit.

Speaking of Colorado, many studies have been conducted regarding CBD for dogs at Colorado State University. Awhile back, researchers at Colorado State University, including Dr. Stephanie McGrath, started looking into the effects of CBD on canine seizures in dogs. Currently, researchers are continuing to conduct research in an attempt to better understand how CBD is absorbed by the bodies of cats and dogs.

We already know that the endocannabinoid system makes it possible for dogs and cats to consume, digest, and make use of cannabidiol CBD. Also known as the ECS receptors, the endocannabinoid system is like a nervous system for cannabidiol CBD. Just like the nervous system, the ECS is a natural system in our bodies that contains cb1 receptors and other related receptors.

Pet owners and their pets alike all have an endocannabinoid system. Within the ECS, there are endocannabinoid receptors which bind to CBD molecules found in CBD products. Without endocannabinoid receptors, a doga wouldn’t be able to break down CBD oils.

Researchers in Colorado are taking it a step further by looking at dogs seizures and how CBD is digested by a dog’s body. Through a clinical trial, researchers are able to look more closely at the effects of CBD on seizures in dogs and cats, too.

The new bill addressed the issue in a far more direct manner, making hemp products legal to manufacture and possess/use. The bill opened the door for CBD oil, produced from hemp, to be sold anywhere, in all 50 states within the US. Some places in the world still haven’t made CBD use legal, so it is best to check before you pack it for traveling out of the country. You should only use it and take it where it is legal or risk legal repercussions in those countries.

What Effects Does CBD Have on a Dog?

Dog owners should do their thorough research before giving dog CBD oil to their dogs with epilepsy. Even though a CBD product is considered safe, the health of your dog is a priority and you should always look into the quality of CBD oil for dogs with dog seizures before administering CBD oil to your dog.

In terms of the effects that CBD oil has on a dog, it has been shown in more than one CBD clinical trial that CBD oil has been used as a pain reliever and seizure reducing supplement when given to dogs with idiopathic epilepsy. Many owners report that it has lessened the severity and frequency of dog seizures. Many times, there is pain that follows seizures because of the intense cramping of muscles during seizures. CBD can also help manage this pain.

Are There Any Negative Side Effects for Dogs?

There are very few, and rare, side-effects from using CBD oil for dogs. The thing most reported is diarrhea. Issues with digestion only seem to happen if the dog or cat ingests too much right away. It takes time for them to adjust to the oil in its system. If diarrhea starts, lower the dose or even skip it for a day or two until it regulates. Then start the treatments again at a lower dosage.

Cannabidiol treats anxiety in many cases, which gives your pet a sense of control again. Anxiety can have physical symptoms that heighten the side effects of a seizure, so adding CBD as part of a dog’s seizure treatment plan can help alleviate anxiety stemming from every seizure, too!

How Much CBD Should You Give a Dog with Seizures?

Speaking of dosage, a dog with seizures will not need the same amount of CBD as every other dog with seizures. Rather, a dog with seizures will require a unique dose based on their body weight. Your dog’s CBD dosage will also depend on existing health problems beyond the seizure they experience frequently, but a seizure will also play a role in calculating the right dosage for your dog with seizures.

When preparing the administer cannabidiol to a dog experiencing seizures, it’s important to read the label on the bottle. Some labels will encourage you to administer a dog’s dosage twice a day, while others will recommend one daily dosage instead.

With seizures, a dog’s frequency may differ. It all comes down to how your dog’s brain responds to each frequency of CBD. For instance, some dogs with seizures may benefit from a higher frequency of two or three doses per day, whereas dogs with less severe seizures might just need one dose per day.

The health of your dog is all that matters, and it’s important to get their health under control, which CBD treats, oils, and supplements can help with! Dogs should be at least 12 weeks old before taking treats or other products. Since seizures stem from the brain, and CBD affects the brain, your dog’s vet will want to make sure your dog’s brain is developed enough before taking it.

How Can I Get a Hold of CBD Oil?

The first thing that you should do, especially if your pet is receiving treatment for any medical issues, is to speak to your veterinarian. Because you work with your veterinarian as a team for your pet’s health, you should both be on the same page. Find out what your vet thinks about using CBD oil and get his permission first.

You also will want to do some research. As fast as you learn about CBD dog, there is new information coming forth. The sheer speed at which research is coming out is mind-boggling. It’s essential to learn as much about it as you can, what is a suitable type of oil, what is the best CBD oil for dogs, and which delivery method you feel is best for your pet. There are treats, edibles, drops, and more that you can choose to give doses to your dog.

Is CBD the Right Option for My Dog?

It is possible. There’s no way to know for sure until you try it and use it long enough to get to the right dose. The research done so far shows that CBD can have a tremendous positive impact on seizure activity. Follow the recommendations, speak to your vet, and do your research. Learn as much as you can so that you can choose a high-quality oil. The more you learn, the better odds you’ll have at helping your dog with CBD.

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Cbd oil patches for back pain

How CBD Patches Can Help Back Pain

Back pain can be debilitating and can gradually destroy your quality of life, impairing your ability to enjoy your free time. Back pain can be related to nerve pain or tissue damage, so it can be difficult to ascertain precisely what the issue is.

Many people are beginning to turn to CBD to ease their pain or inflammation in a particular area that is causing them grief. CBD is an abbreviation of cannabidiol which is one of over 100 cannabinoids that are contained within the cannabis plant. CBD doesn’t get you high as it is not a psychoactive compound. It is THC, which stands for tetrahydrocannabinol, that is the compound within the cannabis plant that causes the user to get high and initiates the feeling of being high, which cannabis has become so infamous for throughout popular culture.

If you are looking to use CBD to manage back pain or any other type of chronic pain, consuming the CBD using a pain relief patch can be an excellent way to ensure that you receive a standardised dose, and the CBD is delivered efficiently. When you apply a CBD patch to the skin, the patch enables the CBD to be absorbed into the bloodstream as the CBD passes through a concentration gradient.

CBD patches are an extremely convenient and discreet way of using CBD, however using a CBD patch is a lot less mainstream than CBD oil. This means that some people remain sceptical about the efficacy of using a CBD patch.

Does a CBD Patch Work?

CBD pain relief patches are certainly as effective as taking CBD orally using a CBD ingestible product. CBD patches offer several benefits compared to using CBD ingestible products such as CBD oils or CBD capsules.

A study that was carried out in 2018 found that CBD patches have several advantages over CBD products that are ingested.

The researchers who conducted the study outline that CBD that is taken orally is often metabolised by the body before the CBD begins to circulate through your bloodstream. CBD that is taken through the skin such as a patch for back pain, does not have to go through this process and is not broken down by the metabolism, meaning that a higher percentage of the CBD enters the bloodstream. This ultimately means that more CBD enters your bloodstream, increasing the likelihood of your pain decreasing.

CBD pain patches are formulated and designed to last for a full 24 hours. This means they are designed to stay active and remained attached to your skin for an entire day. The slower release of the CBD over an extended timeframe. The slow but steady dose ensures that the CBD targets the precise area that is affected by the pain. One benefit of using CBD patches for back pain is that you only have to apply the patch once in the morning, whereas with CBD oil or CBD cream, you have to ensure you take several doses throughout the day to make sure you are ingesting the optimal amount of CBD. In many people’s busy schedules, having to remember to take CBD is not ideal and using a CBD patch negates the risk of forgetting to consume your ideal daily dose of CBD.

CBD pain patches are most effective when you apply them to a venous part of the body. The most effective places to place a pain patch is on the inside of your wrist or outside of your upper arm. A venous part of your body is an ideal place to stick the pain patch as it means that the absorption into the bloodstream is faster and therefore, the CBD is distributed throughout the body at a faster rate.

There was research that was carried out in 2020 that found that topical CBD could be an effective way to decrease inflammation and blocking pain in the recovery of back injuries. Decreasing inflammation is crucial in treating back pain, as inflammation is often a pivotal cause of back pain. The research also found that nerve pain could be relieved by using a topical CBD product such as a CBD patch. Topical CBD applications such as a CBD patches have been proven to promote muscle relaxation in many chronic pain disorders.

There has yet to be substantial research into the effectiveness of CBD patches. However, by conducting a Randomised Clinical Trial or Study could provide the initial evidence to prove that CBD patches are a viable method of treating inflammation and issues such as back pain.

How to choose the best CBD Patches

There are some key criteria to assess when you are choosing the CBD patch you want to use. Safety, quality and brand transparency are all integral when selecting a CBD patch or any CBD product for that matter.

Finding out how the pain patch is made is also crucial. The most effective CBD patches have the CBD and other active ingredients formulated within the patch’s adhesive. This is the most modern and effective way to use CBD patches. Matrix patches are similar to a sticker and the impact is not as substantial.

How to use CBD Patches

CBD patches are incredibly easy to use and are discreet. With a CBD patch that has the CBD contained within the adhesive, it couldn’t be any simpler:

  1. Simply remove the patch from its packaging and then place it on the outside of the top of your arm.
  2. keep the CBD patch on for at least 24 hours and longer if the packaging indicates that this is the optimal timeframe to wear the patch.
  3. Once the 24 hours has passed, it is advisable to apply another patch. This is because CBD has a cumulative effect, and it takes a substantial period of time for the CBD to take effect.

If you are new to CBD, it is probably advisable that you start with a 10mg CBD patch. This is because when first using CBD, it is always best to start with a low dose and gradually build up the dose until you find the optimal dose for you. If you find that you require a more significant dose, then you can try our 20mg CBD patches.

Are CBD Patches Safe?

CBD is considered to be safe and even the common side effects are not serious. The side effects include diarrhoea, loss of appetite, dry mouth and weight loss.

There are a handful of instances where CBD can interact with prescription medications and it is always best to speak with your doctor if you have any concerns or are on prescription medication. It is also not recommended that you use CBD if you are pregnant or breastfeeding.

If you are taking statins, it may not be a good idea to use CBD pain patches, or any CBD product.

Is CBD Legal?

CBD is legal in the UK assuming it doesn’t contain restricted cannabinoids such as THC or CBN.

Ingestible CBD products such as CBD oils and CBD capsules will have to comply with the impending Novel Food Legislation that comes into force on 31 March 2021 and will be enforced by the Food Standards Agency. This is one reason why pain patches are a particularly interesting delivery method, as they do not need to comply with the Novel Food legislation.

Best CBD Patches

CBD patches may possibly provide fast and effective relief from chronic pain within the body. When you apply the patch, the CBD and other ingredients absorb through the skin to directly enter the bloodstream. Because the CBD gradually absorbs, you can wear these patches for up to 8 hours and even longer.

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    CBD per container

    • Athletes (1)
    • Regular Users (1)

    What are CBD Patches?

    CBD patches are an adhesive piece of plastic that resembles a Band-Aid. However, the patch itself is infused with a certain dose of CBD. You can apply this patch to any area of your body that will easily absorb the CBD. The most common parts of the body are the arm, wrist, or ankle. These are areas of the body that are very venous and easily absorb things.

    CBD patches can be used for fast relief from stress, pain, nausea, and much more. They have virtually no side effects, and you can remove your CBD patch whenever you want.

    With a transdermal application when the CBD patch sticks onto a problem area of your skin, CBD directly enters the bloodstream, bypassing the first-pass metabolism process, starts working almost immediately and therefore, it has a much higher bioavailability than oral methods (the CBD bioavailability rate of the transdermal method is 95%).

    How to Use CBD Patches?

    1. Choose an area where you will apply the patch.
    The key to effectively wearing a patch is to choose an area of your body where you know that capillaries and blood vessels are relatively close to the surface. This often means a spot where you can see your veins just below the surface of the skin. For most patch wearers, this means the wrists, upper arms, shoulders, or back of the neck.

    2. Tear open pouch.
    Apply the patch to a clean area of skin such as the upper arm or leg. For pain patches, apply to the affected area. Wash hands after applying or removing the patch.

    3. Watch the wear time.
    Wear time varies for the patches by different manufacturers. Always use as directed on the product packaging. Hemp Bombs patches may be worn up to 8 to 12 hours, Pure Ratios patch stays on and delivers consistent dosage for up to 96 hours.

    4. Do not apply to wounds.
    Do not apply these CBD topical products to wounds, damaged or irritated skin. Don’t bandage or cover with any wrap except clothing, and don’t use them with any heating pads.

    5. Peel off to remove the CBD patch.
    Some people may have difficulty removing transdermal patches due to sensitive skin. If you generally experience problems removing patches, try soaking the patch off with warm water. Applying oil may help break down the adhesive to make removal easier. Completely clean any residual oil to assure that your next patch will stick to your arm.

    CBD Patches Pros and Cons

    1. Health benefits.
    A CBD patch is just another form of CBD that you can use for a large variety of health conditions. Just like a tincture or capsule, patches allow you to naturally balance your body in order to feel your best.

    2. Quick absorption and delivery.
    You can apply a patch where you feel you need it most, but applying it to an area with quick absorption and delivery through your body will provide the optimal results.

    3. Easy and discreet use.
    CBD Patches are easy to apply and can be worn under clothes for discreet use. However, it’s not recommended that you cover your patch with anything else or apply heat.

    4. They can be used with other CBD products.
    You may benefit from using CBD edible products in conjunction with CBD patches. When used alone, the patches mostly impact the area of attachment. Using edible products (capsules, pills, edibles) also gives you an overall wellness boost that you may not receive from the targeted relief of patches.

    5. Buying in quantity reduces your price.
    Pure Ratios 5-patch pack costs $59.99 ($11.9 per count), while 1-patch pack costs $14.40.

    1. Difficulties with CBD patch removal.
    Some people may have difficulty removing transdermal patches due to sensitive skin.

    2. Possible allergic reactions.
    The product may cause allergic reactions in some individuals.

    How Much Do CBD Patches Cost?

    Hemp Bombs, Hangover CBD Patches, Broad Spectrum THC-free, 100mg CBD

    Social CBD, CBD Infused Patch, Isolate THC-Free, 3ct, 100mg/patch, 300mg CBD

    Social CBD, CBD Infused Patch, Isolate THC-Free, 3ct, 60mg/patch, 180mg CBD

    CBD Patches Customer Reviews

    Social CBD, CBD Infused Patch, Isolate THC-Free, 3ct, 100mg/patch, 300mg CBD

    by Roger Reynolds

    Social CBD, CBD Infused Patch, Isolate THC-Free, 3ct, 60mg/patch, 180mg CBD

    by Machelle Blue

    Hemp Bombs, Hangover CBD Patches, Broad Spectrum THC-free, 100mg CBD

    Pure Ratios, 96 Hour Transdermal Hemp Extract Patch, 5-count

    by Anna raynock

    Pure Ratios, 96 Hour Transdermal Hemp Extract Patch, 5-count

    Pure Ratios, 96 Hour Transdermal Hemp Extract Patch, 5-count

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    Pure Ratios, 96 Hour Transdermal Hemp Extract Patch, 1-count

    by Aida Anderson

    Pure Ratios, 96 Hour Transdermal Hemp Extract Patch, 1-count

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    Pure Ratios, 96 Hour Transdermal Hemp Extract Patch, 5-count

    by Bradford Norton

    Social CBD, CBD Infused Patch, Isolate THC-Free, 3ct, 100mg/patch, 300mg CBD

    by Dylan McCary

    CBD Patches FAQs

    How long do CBD patches last?

    When applying CBD pain patches, you can administer CBD into your system for 8 to 12 hours on average. If you do not want the patches to deliver consistent dosage, you can easily remove them from your skin.

    How many CBD patches should you use for pain relief?

    CBD patches are designed to administer a specific amount of CBD into your system over an extended period of time. It’s recommended that you start with one patch for pain relief and pay attention to how it makes you feel. If you feel like you need more, then you have the option of adding more patches.

    You might consider consulting your doctor to determine how many CBD patches you can or should use for pain relief.

    Where do you put CBD patches?

    CBD patches are most effective when applied to the parts of your body that have a lot of veins. This includes on the inside of your wrists, upper arms, shoulders, back of your neck or ankles. CBD patches might also be beneficial if applied directly to the area that is experiencing discomfort.

    How effective are topical CBD patches?

    The effectiveness of topical CBD patches will depend on several factors, including the ailment you are trying to treat and the results you are hoping for. As a CBD delivery system, they are effective at getting CBD into your body, so you may be able to feel the results quickly and have them last for hours.

    How do CBD patches feel?

    Applying a CBD patch to your body shouldn’t feel any different than wearing a band-aid. The only thing you should feel is relief from the pain and/or inflammation that has been bothering you.

    How long do you wear a CBD patch?

    Depending on CBD brand you get, CBD patches can be applied for 6, 12 or even 96 hours. Please follow full instructions enclosed in the packaging.

    The statements above have not been evaluated via the Food and Drug Administration. The efficacy of these merchandise has not been tested by using FDA-approved research. These products are not intended to diagnose, treat, therapy, or stop any disease.

    Understanding CBD (Cannabidiol) for Back Pain

    Cannabidiol, commonly referred to as CBD, is a new and relatively understudied treatment for pain, including back pain. Studies suggest it may help relieve inflammation, which is often a factor in chronic back pain. 1

    CBD is available in many forms; topical creams and gels have shown promising results for inflammation and neuropathy, which may make them a good option for back and neck pain. 2

    CBD requires more research in order to prove and explain its effectiveness as well as to better understand potential side effects (especially long-term) and potential drug interactions.

    What Is CBD?

    CBD oil is derived from a plant called cannabis sativa. The plant has over 100 chemical compounds, called cannabinoids, that have a range of effects, including anti-inflammatory and analgesic (pain relieving) qualities.

    The cannabis sativa plant has two main varieties that are grown for specific purposes:

    • THC content. THC is the compound associated with the “high” feeling of marijuana use.
    • Industrial (non-drug) uses. This form of the plant contains trace amounts of THC (less than .03%) and can be used to make paper, clothing, and some building material. This variation of the cannabis plant is called hemp.

    While CBD is present in both varieties, many of the CBD products available to consumers are from the hemp plant. CBD does not come with the high or psychogenic effects of marijuana.

    Ways CBD Treats Back Pain

    Research indicates that CBD may reduce back pain by:

    • Reducing inflammation 3
    • Combating anxiety, often associated with long-lasting or chronic back pain 4
    • Helping with sleep and improving overall state of relaxation 5

    Some studies suggest that CBD can have an effect on how an individual perceives pain, but more robust research is needed. CBD is generally considered a full-body treatment, which means that it does not target back pain specifically—except in the case of topical products—but contributes to an overall feeling of relaxation and pain relief.

    Advocates of CBD believe it can be used to treat a range of conditions in addition to back pain, such as anxiety-related disorders. 5

    Potential Risks and Side Effects of CBD

    Cannabidiol, even in high amounts, is generally safe. Side effects from CBD may include:

    • Drowsiness
    • Dizziness
    • Dry mouth
    • Low blood pressure

    More severe side effects, while rare, include:

    • Mental confusion
    • Nausea
    • Vomiting
    • Diarrhea

    As with other natural products, there is potential for adverse reactions when taken with other medications, especially those that come with grapefruit warnings, such as certain blood thinners. These warnings indicate that certain medications should not be taken with products containing grapefruit.

    CBD use prior to surgery

    Before having surgery, all cannabis use, including CBD and marijuana, should be disclosed to the surgeon or anesthesiologist. A recent study suggests that cannabis use may have an effect on medications used to sedate patients. 6

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Best rated cbd oil for back pain and anxiety

10 Best CBD Oil for Back Pain

This article contains affiliate links to products. We may receive a commission for purchases made through these links.

Back pain is a condition that impacts millions of people around the world. It makes simple tasks, such as walking or laying in bed, uncomfortable at best. If you live with chronic back pain, you may be willing to try almost anything to make the pain levels more bearable.

Often, traditional forms of therapy do not produce the expected results. In turn, people look for alternative solutions to heal their back pain. Today, there’s an abundance of health advice and innovative products on the market. Many promise to reduce pain and discomfort while supporting a healthier, happier life.

But as you know, you can’t take product promises at face value. There are all sorts of companies out there that promise a miracle product, only for it to offer little to no benefits.

Over the last few years, CBD oil has become a popular choice for treating back pain. Because of its many therapeutic benefits, CBD products have and continue to be in high demand. Ever since the compound was legalized in 2018, there’s a substantial supply of products that can be used to treat chronic pain while also managing anxiety.

With so many products on the market, it can be hard to choose a product that will offer the benefits that you seek.

How to Choose Quality CBD Oil

As you’d expect, there are tons of CBD oils on the market that can be used to treat back pain or pain anywhere on the body. Choosing the right brand and knowing how to choose a quality product from a low quality product isn’t an easy task.

Just as there are reputable CBD companies with high standards, there are others that manipulate you into buying a product that is made with low quality ingredients. This is why it’s so important to know how to choose quality CBD oil.

It starts by researching the brand and their products. In conducting your research, there are various factors to consider.

First, look at the type of CBD that the company uses. Quality CBD comes from quality products. Find a brand that uses CBD sourced from organic, non-GMO hemp. Reputable brands publish a product’s full ingredients list on the label as well as online.

If you find a company that uses organic CBD along with all natural ingredients, chances are that you’ve found a product that you can trust.

The next factor to consider is THC content. CBD is only one of several cannabinoids that naturally occur in hemp. THC, which is short for tetrahydrocannabinol, is known for causing psychoactive effects.

The type of CBD extract used indicates the THC level. CBD isolate and broad spectrum CBD contain no THC. On the other hand, full spectrum CBD contains all of the plant compounds, including THC. However, the product should contain no more than 0.3% THC. Otherwise, it’s illegal and may cause unintended side effects.

A reputable company knows the importance of transparency. Companies that produce the best CBD oil submit their products for third-party lab testing, and the results are publicly available. These tests show the product’s purity and quality. They check for the presence of harmful compounds such as pesticides, heavy metals, and solvents.

Top 10 CBD Brands for Back Pain

Because there are countless CBD oil products to choose from, we’ve done all of the tedious research for you. We’ve taken all of the above factors into consideration when ranking CBD brands. Here’s what you need to know about each brand.

1. Penguin

Penguin is a premium brand that creates premium products that contain no THC. All of their products are made using the best Oregon-grown hemp that is designed to rejuvenate the mind and body.

This brand is inspired by nature. Their products are GMO-free and contain zero pesticides. Enjoy your own slice of the penguin life with these CBD products. They’ll keep you cool, calm, and collected all while feeling your best. Goodbye back pain!

Each batch is made using refined broad-spectrum extract. Penguin is available in some of the most delicious flavors including citrus, mint, strawberry, and cookies and cream. CBD oil is available in several strengths, including 250mg, 600mg, 1000mg, 2500mg, and 5000mg.

2. Everest

Everest is a fresh new name in the CBD market, and they’re definitely one to leave an impression. Their CBD oil and gummies are made with the highest standards of quality, which you can see reflected in their independent, third-party lab results. They also offer several Delta 8 products as well.

Pros: One of the best-tasting oils on this entire list, with its sweet blueberry flavor. It’s also one of the most potent, as its formula is stacked with a variety of cannabinoids and terpenes. Shipping is free for all 50 states and comes in discreet packaging. Subscriptions can be paused or cancelled at any time without any penalty.

Cons: Everest only offers one flavor at the moment, so people who aren’t blueberry fans might be disappointed. It also only comes in 1500mg strength. Price is a little on the higher side, but that’s expected with a premium quality product.


FOCL’s CBD drops get rave customer reviews and rank among the best in the industry for three simple reasons – high quality, amazing taste, and great value.

For maximum relief from everyday back pain, FOCL’s 2000mg Natural CBD Drops get the job done.

Made with broad spectrum CBD oil and Organic MCT (coconut) oil, FOCL 2000mg Natural CBD Drops are the perfect dose of CBD for relief from back aches and pains. They are also flavorless, which makes them super convenient for adding to your coffee, smoothies, or just some under your tongue for immediate relief.

In terms of taste, FOCL Natural Drops are some of the best we’ve tried because they don’t have that weird grassy aftertaste. They also offer 1000mg CBD drops in mint, strawberry lemonade, cherry, and orange cream!

FOCL also produces an incredibly powerful CBD Relief Cream made with hemp extract and other proven botanicals – it’s one of the best CBD topicals we’ve tried for aches and pains. For the best value, check out their popular “ Relief Bundle .”

4. Sunday Scaries

For everyday pain management, we highly recommend Sunday Scaries . This CBD oil is made with broad spectrum extract that’s combined with vitamins and coconut oil. To improve the effectiveness of their CBD oil, the brand infuses it with vitamins B12 and D3, both of which are known to help with pain management.

According to the National Institute of Health , studies have shown promising effects of using vitamin D for reducing muscular pain. The National Library of Medicine has found that vitamin B12 may be a supplemental tool to use for treating pain.

Even coconut oil plays a role in managing pain and discomfort. Human studies have found that coconut oil reduces the markers of inflammation and oxidative stress.

5. Medterra

Medterra hits the mark for all of the most important factors, including quality, hemp source, clean formulations, and testing standards. This is a brand that has very few gaps. Medterra is well known for its high quality products, including CBD isolate and broad spectrum products. They also offer full spectrum products now as well!

The brand’s True Full Spectrum CBD drops are the most advanced tincture on the market. The oil is made with 2mg of THC and is formulated with a 5:1 CBD to other cannabinoid ratio. Unlike most full spectrum oils that contain a trace amount of THC, True Full Spectrum contains a significant amount of THC.

What does this mean for you? Products with higher CBD levels work faster and the effects last much longer. When CBD is combined with THC and other minor cannabinoids, you’ll experience the entourage effect. This magnifies the benefits of each plant compound.

If you’re looking for a quality product that’s effective, Medterra’s True Full Spectrum oil is just the product for you.

Use Code: DM15 for 15% off your order.

6. HealthWorxCBD

Another company that offers trusted CBD oil is HealthWorxCBD . This company is based in Denver, Colorado. Products are made using the finest Colorado hemp that is grown using safe farming products.

The brand offers both full spectrum CBD oil as well as pure CBD oil. Potencies range from 200mg to 5000mg. HealthWorxCBD also offers a unique extract known as terpene-enhanced CBD. According to customer reviews, HealthWorxCBD oil is effective in treating pain.

All products are tested by a third-party lab and results are available on the brand’s website.

7. Kiara Naturals

Looking for a strong CBD product that’s specifically designed for pain? Kiara Naturals is a brand that you can rely on for quality products. This Swiss manufacturer is known for its high potency products that are meant to treat specific health issues.

Kiara Naturals is a family-owned business that makes all CBD products by hand. CBD oils and other products are made in small batches in Appenzellerland, Switzerland following strict GMP standards.

The brand’s products are used by natural health practitioners across Europe.

Kiara Naturals CBD oils are available in strengths ranging from 1000mg to 3000mg. Their pain tincture is specifically formulated using full spectrum CBD along with other natural products that address pain in various ways.

8. Verma Farms

Verma Farms is one of the most trusted names in the CBD industry. While they’re most known for their Hawaii-inspired CBD gummies, they’ve also created a full line of delicious CBD oil. If you’re looking for a high quality oil that’s made with all natural, organic ingredients, Verma Farms is a safe choice.

Verma Farms products are formulated using unadulterated, powerful, and pesticide-free broad spectrum CBD extract that promotes rejuvenation, rest, concentration, and the ultimate pain relief. Place a few drops under your tongue or add oil to your favorite beverage to keep back pain at bay.

The brand offers some of the most deliciously flavored CBD oils, including pineapple, mango, mint, strawberry, watermelon, and others. Oils are available in two concentrations, 500mg and 1000mg.

9. Pure Kana

Pure Kana is another worthy brand that we’re proud to put on our top 10 list. This company is based out of Arizona. Their products are formulated using organically grown hemp plants from Kentucky.

They offer a full line of CBD hemp oil that is designed to meet all of your daily wellness needs. Pure Kana oils are available in many flavors, including:

Oil strengths range from 300mg to 5000mg, so you’re sure to find one that best relieves your back pain.

10. Charlotte’s Web

Charlotte’s Web is well-known for its high quality CBD products, including CBD oil. The brand is based in Colorado and specializes in CBD products made using top notch organic CBD.

Aside from their original formula, CBD oil is also available in some of the most delicious flavors you’ll find on the market, including mint chocolat, lemon twist, and orange blossom.

Whether you’re a first-time CBD user or well-seasoned in using the cannabinoid, Charlotte’s Web has a product that will meet your needs.

When compared to other CBD oils on the market, Charlotte’s Web products are on the expensive side. However, you get what you pay for. High quality products are often sold at a higher price tag.

Bonus: CBDistillery

CBDistillery is well known for creating high quality CBD oil that is made using CBD isolate, broad spectrum, and full spectrum CBD. Their products have proven to be one of the most effective in treating a variety of health conditions.

Aside from pure CBD oil, CBDistillery also offers full spectrum oil, which can be quite effective in treating back and other forms of pain. Each of their products is lab tested for purity and quality. CBDistillery posts all lab results on their website so that consumers can easily review them.

While most of their products contain no flavoring, CBDistillery does offer a mango flavor for certain products.

Bonus: Balance CBD

Balance CBD was founded by two health professionals with the aim of helping people ease their pain while also encouraging relaxation. All of their products are made using all natural, non-GMO, organic ingredients. Balance CBD products contain no artificial colors, sweeteners, or flavors.

The brand offers THC-free and full spectrum CBD oil that’s available in various strengths ranging from 500mg to 5000mg.

Balance CBD products are organic, gluten-free, vegan, allergan free, and are manufactured using GMP quality standards. When you buy from Balance CBD, you’re supporting a small business with a big dream.

Is CBD Legal?

Under the 2018 Farm Bill, hemp-derived products were legalized. However, the law stipulates that CBD products must contain no more than 0.3% THC due to the cannabinoids psychoactive products. While the bill is legal at the federal level, not all states regulate CBD products the same way.

For example, in Colorado, it’s legal to use all parts of the hemp plant. In Texas, any product that contains THC is illegal. While most states are friendly towards CBD products, it’s important to check your state’s laws before buying.

CBD regulations also vary from country to country. Check the regulations that apply to you to ensure you can legally buy CBD products.

Buyer’s Guide

It’s not enough to know which brands offer high quality CBD oil. If you decide to give CBD oil or any other CBD product a try, it’s also important to figure out the right dosage for you. Currently, there is no recommended daily intake of CBD that’s regulated by the FDA.

In turn, people rely on the advice provided by CBD manufacturers. Most CBD companies recommend one dropper of CBD per day. But, this dosage may be too high or too low for your needs.

When deciding which dosage is best for you, consider the product’s CBD potency as well as your weight and the condition you’re looking to treat. CBD oil is available in various strengths, which means that a dropper could contain 300mg of CBD or 3,000mg. These potencies will have very different effects.

There are also personal factors, such as your body weight, which impact how you react to CBD. Because there isn’t a standard dosage for everyone, finding your right dosage requires some trial and error.

Final Thoughts

With our top 10 list of CBD oils, finding the right product to ease your back pain has never been easier. While we’ve conducted our research, it never hurts to do your own digging to give yourself peace of mind that you’re choosing a product that will work for you.

Remember, everyone reacts differently to CBD oil. If you’re new to CBD products, start with a low dose (or low potency CBD oil) and slowly increase the amount. This reduces the risk of having an adverse reaction.

As with any product, always consult with a medical professional before adding CBD oil to your daily routine.

Looking for the best CBD you can find? Check out our awards for the best CBD Gummies , best CBD Oi l, Best CBD Oil For Dogs , and Best CBD Oil for cats .

Best CBD Oil for Pain Relief & Inflammation: Highest Quality Brands On The Market

Over the past three years, CBD oil has become increasingly popular as a health and wellness supplement.

One of the main reasons people are interested in trying CBD oil is because of its pain-killing benefits. We’ll get into the details of how CBD is suggested to help with pain later, along with some suggestions for the best CBD oils for pain and inflammation.

The ability for CBD to help with pain is a significant advantage over conventional pain management options — which often involve addictive and potentially harmful medications. Instead, this natural supplement has very few side effects and an exceptional safety profile — all without compromising on effectiveness.

But how do you choose the right CBD oil for the job?

This is an important question to ask because the truth of the matter is that not all CBD oils work. Many simply contain too little CBD to be of any help, while others contain harmful contaminants like heavy metals, pesticides, or chemical solvents — all of which could add to the pain you’re already experiencing by damaging the sensitive nerve cells around the body.

We’re going to cover all of this in the article below. You’ll learn how to spot a high-quality CBD oil and how current evidence shows CBD to work inside the body.

This is a big topic, so let’s get started with our list of top-rated CBD oils for pain.

Top 10 Best CBD Oil Brands for Pain Management in 2022

Not sure which CBD oil to buy to help with chronic pain? Before we get into the nitty-gritty of how CBD is suggested to work for pain and inflammation, here’s our top 5 list of CBD oils I’ve used myself for back pain.

We’ll also offer some advice on a few ways you can spot a trustworthy CBD vendor even if they didn’t quite make it onto our list.

I’ve been using CBD for over 5 years now and I’ve stumbled upon some stellar companies with top-notch oils and fly-by-night businesses with oils that can’t simply don’t work.

I have a relatively short list of CBD brands that I fully trust and I want to share my choices with you so you can avoid some of the headaches and disappointment I’ve already endured.

Here are my top 10 CBD oil brands for pain:

1. Royal CBD (Best CBD Oil On The Market)

Technical Details
Total CBD Content 250 – 2500 mg
Available Flavors Natural, Mint, Vanilla, Berry
Potency 8.3 – 83.3 mg/mL

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

Why Royal CBD is My Top Pick:

As skeptical as I am towards the majority of new CBD brands, I decided to give Royal CBD a try because I liked the company’s dedication to quality. I love seeing companies that take what they do seriously.

You can tell right away from the color, flavor, and consistency of the oil that you’re dealing with a product well above average.

This oil is cheaper than most of the other premium CBD oils I’ve tried, comes in a full range of potencies, and uses some of the best full-spectrum hemp extracts I’ve ever seen. I’ve heard friends using this brand for quite some time and decided to give it a try for myself — so I ordered a few bottles in different strengths.

After taking the Royal CBD’s 2500mg full-spectrum CBD oil for just over a week, I noticed an improvement in my back pain. There was a time when I had serious problems falling asleep because of the sharp pains in my back that seemed to intensify whenever I laid down to fall asleep. It was a nightmare. I’d lay awake for hours changing positions to try and find a spot that didn’t leave me writhing in discomfort.

With this oil, my experience went far beyond what I expected. Not only did it help ease the pain, but my overall quality of sleep improved. I mean, I didn’t sleep longer but I began to wake up rested and with a clear head.

My favorite combination for this particular oil is the vanilla in the 1000 mg bottle. This is the largest potency option currently offered by Royal CBD and has the best value overall. I took the oil twice per day, once in the morning when I woke up, and again in the evening before bed. One bottle of the 1000 mg CBD oil lasted me about a month.

  • Sourced from US-grown organic hemp
  • Extracted with supercritical CO2
  • Contains the full spectrum of cannabinoids and terpenes
  • Available in 4 different strengths
  • Up to 2500mg of CBD per bottle
  • Lab-tested for potency and purity
  • Great natural flavors (no aftertaste and comes in multiple flavor options)
  • Free shipping within the USA
  • Newer brand on the market that only sells online, no physical presence

2. Gold Bee (Best Organic CBD Oil)

  • Premium Colorado-grown hemp
  • CO2 extraction
  • Contains full-spectrum CBD
  • Delicious kiwi flavor
  • Sweetened with organic honey
  • Lab-tested for potency and purity
  • Only one flavored option available
  • No high-strength oils (yet)

What I Like About Gold Bee:

I honestly believe Gold Bee makes the best organic CBD products out there. The brand combines premium Colorado-grown hemp with organic honey sourced from the Brazillian Rainforest. While Gold Bee offers a modest selection of oils — with up to 1200 mg of CBD per bottle — the formula is spot-on when it comes to the quality of ingredients. I’m totally not going to complain about the potency, as my back pain and sleep quality got better than with some high-strength oils I’ve tried in the past. Considering the quality of these products, they actually come at a bargain price. If you want to try other formats from Gold Bee, you can choose between its high-strength capsules and CBD-infused honey.

3. CBDPure (Runner Up)

Technical Details
Total CBD Content 100 – 600 mg
Available Flavors None
Potency 1.6 – 10 mg/mL
What I Like About CBDPure CBD Oil:

I love how transparent this company is. If I were judging companies solely by their transparency level, CBDPure would have scored the second place, right after Royal CBD. The company provides all the details about each stage of production when making this CBD oil. You can find all the third-party lab test results for each batch on the product page — something we’ve come to expect from any high-quality CBD company.

What really makes this company stand out is its incredible satisfaction guarantee. If you order the product and decide it wasn’t working for you, simply send it back and get a full refund. This satisfaction guarantee extends over 3 whole months — which is about three times longer than the industry average.

I keep a bottle or two of CBDPure oil in my medicine cabinet for achy moments after a run or hike with the kids.

The only real downside to this oil is the potency — which comes in denominations of 1.5, 5, and 10 mg/mL. This is suitable for more minor symptoms, but may not be enough for people with heavy CBD demands.

  • Sourced from Colorado-grown organic hemp
  • Extracted with supercritical CO2
  • Tested for the cannabinoid content and purity in a third-party lab
  • Rock-solid 90-day return policy
  • Narrow product range
  • Low potency
  • They don’t ship to every state (i.e. Louisiana, Indiana, Arkansas, Kansas)

4. HempBombs

Technical Details
Total CBD Content 300 – 4000 mg
Available Flavors Unflavored, Acai Berry, Orange Creamsicle, Peppermint, Watermelon
Potency 10 – 133.3 mg/mL
What I Like About HempBombs:

I used HempBombs CBD isolate-based hemp oil for quite some time before switching to full-spectrum CBD oil and in my opinion, this is the best brand when it comes to CBD isolates. Their products contain 99% pure CBD and ZERO THC.

Now don’t get me wrong, CBD isolates are great, they offer consistent doses of CBD, contain 0% THC, and are generally cheaper than their full-spectrum counterparts. In most cases, I like using a full-spectrum extract like Royal CBD oil because of something called the entourage effect — which is a concept highlighting the phenomenon where cannabinoids like CBD tend to work better when other hemp-derived compounds are also present.

In isolates, the only cannabinoid present is CBD.

HempBombs CBD oil is available in five different strengths — from 300mg to 4000mg per bottle. The CBD is added in the form of a 99% pure isolate — which means there’s going to be virtually no traceable amounts of any other cannabinoids, including THC, CBC, CBG, or CBN.

You can also buy these oils in different flavors. Hemp Bombs often adds new flavors to the list, but my all-time personal favorite is the Acai berry. It’s not too sweet but adds a really pleasant flavor to the otherwise bland CBD and MCT oil formula.

  • Sourced from 100% certified organic hemp from European farms
  • Extracted with supercritical CO2
  • Completely THC-free
  • Tested in third-party laboratories for purity and potency
  • Available in 5 separate strengths
  • Up to 4000mg of CBD per bottle
  • Lacks the synergistic effects from other cannabinoids
  • The highest potencies are overkill for most users
  • Uses synthetic flavoring agents

5. CBDistillery

Technical Details
Total CBD Content 250 – 5000 mg
Available Flavors None
Potency 8.3 – 166 mg/mL
What I Like About CBDistillery:

CBDistillery is now one of the largest CBD companies in North America. The company began in 2016 as a legacy brand for Balanced Health Botanicals.

Over the years, CBDistillery has had the chance to really dial-in its CBD oil formula. The company now sells its CBD oil in two formats — “full-spectrum” and “THC-free.” The THC-free option is great for people who want to benefit from the synergy of CBD and other cannabinoids but without bringing any THC whatsoever into their system.

Even the full-spectrum option contains less than 0.3% THC — which is well below the amount needed to cause any psychoactive effects. These oils are both completely non-psychoactive.

You can choose between five different strengths, starting at 250mg up to 5000mg of CBD per bottle. This covers just about every range of potencies you would ever need. We recommend opting for the higher potency options because they have the best value overall. The higher potency you purchase, the further your dollar gets you.

The more potent options also las the longest because you need smaller amounts of the oil each time to get the desired dose of CBD.

I tried the 1000mg bottle to keep myself calm during the first few months after giving birth to my first son and I must admit it helped me maintain my sanity during that time. I found it to have a remarkable calming effect on the body and mind.

  • Available as full-spectrum CBD or pure CBD oil (THC-free)
  • 5 strengths to choose from
  • Carries up to 33.3 mg of CBD per mL (in the 1000 mg bottle)
  • Excellent value CBD oil
  • The hemp isn’t certified organic
  • No flavor options available
  • The company website is clunky and hard to navigate

6. NuLeaf Naturals

Technical Details
Total CBD Content 240 – 4850 mg
Available Flavors None
Potency 48.5 mg/mL
What I Like About NuLeaf Naturals

Nuleaf Naturals is one of the most popular CBD companies in the United States — most likely related to how long the company has been in the business of selling CBD. Nuleaf naturals were one of the first CBD companies to enter the mainstream market.

Despite the companies longstanding reputation, Nuleaf Naturals only sells one CBD oil. When you go to the website you’ll find a few different options, including a pet oil — but it’s important to understand that these are all the exact same full-spectrum extract, the only difference is the bottle sizes.

We love the simplicity of Nuleaf Naturals product lineup. The oils come with a decent potency of around 48 mg/mL, and just about every bottle size you can imagine. This makes it easy for everybody to find a product that works for them regardless of the budget.

With that said, if you have the cash, we highly recommend getting the larger bottle sizes in order to get the best value for your money.

You can choose between five different sizes:

  • Sourced from organic Colorado-grown hemp
  • Extracted using supercritical CO2
  • Made from a full-spectrum hemp extract
  • More expensive than the other brands in this ranking
  • Narrow product range

7. Charlotte’s Web

Technical Details
Total CBD Content 200 – 1800 mg
Available Flavors Mint Chocolate, Lemon Twist, Orange Blossom, Olive Oil
Potency 7 – 60 mg/mL

About Charlotte’s Web:

Charlotte’s Web is one of the pioneers in the American CBD industry. Established by the Stanley Brothers, the company has coined a reputation of a trustworthy manufacturer by helping now late Charlotte Figi with her treatment-resistant epilepsy. Although the company has recently received a warning letter from the FDA due to their health claims, they still have many faithful customers and a massive number of positive reviews on the web.

Charlotte’s Web CBD oil comes in several potencies: 200 mg, 500 mg, 1500 mg, and 1800 mg of CBD per bottle. The highest strength offers 60 mg of full-spectrum CBD per milliliter. There are two bottle sizes to choose from: 30 mL and 100 mL; Charlotte’s Web also has flavored variants of its CBD oil, including Lemon Twist, Orange Blossom, Mint Chocolate, and Olive Oil.

What could the company do better?

First off, they could change their extraction method because they use ethanol, which is less efficient than CO2 extraction. Secondly, and most importantly, the suspension in olive oil makes them taste a bit bitter — even in the flavored versions.


  • One of the most reputable brands on the market
  • Full-spectrum CBD
  • Delicious flavored versions
  • Up to 1800 mg of CBD per bottle
  • Available in two sizes: 30 mL and 100 mL
  • Third-party tested for potency and purity


  • Non-organic hemp
  • Ethanol extraction
  • Suspension in olive oil (bitter taste)
  • The company received a warning letter from the FDA in the past due to inappropriate health claims

8. cbdMD

Technical Details
Total CBD Content 300 – 7500 mg
Available Flavors Natural, Berry, Orange, Mint
Potency 10 – 250 mg/mL

About cbdMD:

cbdMD is another popular manufacturer that offers a wide range of CBD extracts, from tinctures to gummies to capsules, bath bombs, topicals, sleep aids, and pet products.

The brand offers a wide range of pure CBD oils, with up to 7500 mg of CBD per bottle. The highest potency comes with a whopping dose of 200 mg of pure CBD suspended in MCT oil for higher bioavailability and a smoother flavor. cbdMD also has three flavored CBD oils: Berry, Orange, and Mint.

Despite an impressive potency range, cbdMD uses broad-spectrum CBD in their products, which doesn’t evoke the full entourage effect. The higher potency may not necessarily mean better results in this case.

The company has high transparency standards; not only does cbdMD broadly describe their activity from farming to testing, but they also provide batch-specific certificates of analysis for their products, including the results for potency and common contaminants like pesticides, heavy metals, and residual solvents.


  • US-grown, non-GMO hemp
  • CO2 extraction
  • THC-free
  • Up to 7500 mg of CBD per bottle
  • Batch-specific certificates of analysis


  • Limited entourage effect due to the lack of THC
  • Most people don’t need such high doses of CBD in their routine

9. Medterra

Technical Details
Total CBD Content 500 – 3000 mg
Available Flavors Natural, Citrus, Mint Chocolate
Potency 16 – 100 mg/mL

About Medterra:

Medterra is a small craft company from California. The brand offers premium CBD oils in different spectra: full-spectrum CBD, broad-spectrum CBD, and isolates. The potency of these products ranges between 500 mg and 3000 mg of CBD per bottle, which is a standard range. On top of the unflavored version, there are two flavored options: Citrus and Chocolate

Medterra prides itself on making the real full-spectrum CBD because each bottle of its full-spectrum CBD oil comes with 2 mg of THC. However, these products are only legal in the states that have legalized higher amounts of THC for recreational use. So, if you want to buy the company’s products in all 50 states, your options are limited to broad-spectrum CBD and CBD isolate. These provide more CBD per bottle — upwards of 1000 mg.

The entire Medterra’s product range is tested in a third-party laboratory for their CBD content and safety.


  • Premium-grade CBD oils
  • Up to 3000 mg of CBD per bottle
  • Available as full-spectrum CBD, broad-spectrum CBD, and isolates
  • Lab tested for potency and purity


  • The “real” full-spectrum CBD oil isn’t available in all states
  • Some of the lab reports indicate higher CBD levels than stated on the bottle
  • No discounts for returning customers

10. Joy Organics

Technical Details
Total CBD Content 450 – 900 mg
Available Flavors Tranquil Mint, Fresh Lime, Summer Lemon
Potency 15 – 30 mg/mL

About Joy Organics:

Joy Organics holds the reputation of one of the most reputable CBD vendors in the industry. The company was established by a woman named Joy Smith, who has been using CBD oil to manage her problems with pain and sleep. After experiencing the benefits of CBD first-hand, she has decided to share her passion for cannabis with other health-conscious consumers.

The brand sells a range of broad-spectrum CBD products from certified organic hemp. They have many positive reviews all over the Internet; they also haven’t received any warning letter regarding health claims from the FDA — unlike many companies in this space (even the veterans like Charlotte’s Web).

The Joy Organics CBD oil features a broad-spectrum CBD formula in a modest potency range, from 450 to 900 mg of CBD per bottle. You can choose from three refreshing flavors: Summer Lemon, Fresh Lime, and Tranquil Mint. The strongest version of the Joy Organics CBD oil contains 30 mg of broad-spectrum CBD in every milliliter, which is a standard dose for most people who take CBD oil for daily supplementation.

In 2018, one of the company’s flavored CBD oils was found to contain a fungicide that is commonly sprayed on citrus fruit during independent lab testing. Fortunately, Joy Organics recalled the product shortly after this incident and implemented a new third-party testing system to make sure there are no flaws in the end product.


  • Non-GMO, US-grown hemp
  • Supercritical CO2 extraction
  • Broad-spectrum CBD
  • THC-free
  • Delicious flavors


  • A bit expensive
  • No high-strength oils

CBD Oil for Pain Management: Complete Guide for Beginners

Now that we’ve covered a few CBD oil options that are going to provide the best value for your money, let’s discuss how CBD is suggested to support chronic pain in the first place. We’ll also cover some of the most common ways people are using CBD oil for pain.

What is CBD Oil?

CBD stands for cannabidiol _ it’s one of the primary active ingredients in the cannabis plant. It’s completely non-psychoactive and offers a wide range of benefits to the human body.

CBD oil is a combination of a CBD extract, with a carrier oil to help dissolve and store the CBD. Most CBD oils use carrier oils like MCT oil, or hemp seed oil — which is then combined with CBD isolate, or full-spectrum hemp extract rich in CBD and other similar cannabinoids.

Cannabinoids like CBD are fat-soluble — which means they dissolve when mixed with oil, but won’t dissolve in water. By dissolving these compounds in an oil solution, the CBD becomes much easier to store and use. Instead of measuring out micrograms of CBD crystals or hemp resin, all you need to do is measure oil to get your dose of CBD. This can be done using a simple dropper that comes standard with most CBD oils.

Because of their ease of use, and long shelf-life, CBD oils have become the go-to method of using CBD and other hemp extracts.

You can also opt-out to use CBD-infused gummies if you wanted something discreetly, read our in-depth review on CBD Gummies to understand better.

How Does CBD Work?

Cannabis has been used for managing pain and inflammation for thousands of years.

The earliest records of the medical use of the herb date back to ancient China when the emperor Shen-Nung placed it among other therapeutic substances in the Chinese pharmacopeia (1). The leaves were wrapped around an injury as a poultice to reduce pain and discomfort, and reverse swelling and bruising.

Despite being a known medicine for a long time, scientists have only recently begun to unlock the mechanisms cannabis uses to achieve its important pain-killing benefits.

Since the discovery of the endocannabinoid system in 1992, CBD and other phytocannabinoids have been in the spotlight of modern medicine.

The endocannabinoid system is one of the most important neurochemical networks in the human body (2). It works by interacting with the endocannabinoid system — a series of hormones and receptors that help regulate over a dozen core processes in the human body. The active compounds in the cannabis plant are very similar to the naturally-produced hormones involved with our endocannabinoid system.

By interacting with the endocannabinoid system, CBD and other cannabinoids are able to modulate several key processes, such as:

  • Appetite
  • Immune function
  • Memory
  • Mood
  • Stress
  • Sensory perception (including pain)
  • Inflammation
  • Reproductive health
  • Nerve function
  • Sleep

How Can CBD Reduce Pain Transmission?

How does all of this relate to pain? The answer lies in the way pain is transmitted to the brain.

When we injure ourselves, cells in the immediate vicinity begin releasing compounds that trigger a cascade of inflammation and sensory activation — which is what triggers the pain transmission.

The pain signal is then sent to the spinal cord through a network of nerves distributed all around the body.

Once in the spine, the pain signal is sent through a gateway (opioid and vanilloid receptors) designed to limit the amount of signal that ends up in the brain for processing. This works like a border crossing. The border security decides whether or not you’re allowed to enter and what you can take with you.

In the context of pain, these gateways can limit the amount of pain signal that continues across the border to the brain. If more pain signal is allowed to pass, the brain perceives more pain. If the pain is stopped at the border, the brain perceives less pain.

Conventional pain medications work by activating the opioid receptors acting as a key gateway for pain transmission to the brain.

CBD has a similar effect, but through a different receptor is known as the vanilloid receptors. These vanilloid receptors are tasked with regulating a specific form of pain caused by either heat or inflammation. CBD has been reported to modulate this vanilloid receptor — leading to a reduction in the pain signals sent to the brain from inflammatory causes such as arthritis, muscle damage, or infection, to name a few.

CBD has other ways it can limit pain transmission as well:

  • CBD may reduce inflammation, limiting the initial cause of pain in the body
  • CBD acts as an antioxidant, helping the body resist and recover from damage
  • CBD relaxes muscle fibers, reducing pain caused by muscle spasms and tightness

More research is needed to fully understand how CBD and other active cannabinoids can block pain. Every year dozens of new research papers are published in an attempt to paint a clear picture of how CBD works, how to get the most benefit from the supplement, and what its limitations are.

(Pain Transmission Pathway to the Brain)

Choosing CBD Oil Companies: How to Differentiate the Good From the Bad

CBD has become a lucrative business. Companies are selling a myriad of different CBD oils and other products in an attempt to cash in on the new health trend. This means there are a lot of excellent products coming to market, but it also means there’s a lot of trash as well. It’s important as a CBD user that you understand what makes a CBD oil good, and what makes it bad so you can avoid wasting your money, or worse — using CBD oils that contain harmful or damaging ingredients.

Let’s cover the most important points to remember when shopping for CBD oil online or in-store.

1. Check the Hemp Source

The source of the hemp used to make the oil is vitally important when it comes to determining which CBD oils are the best. The main reason comes down to the botany of the hemp plant itself.

Hemp is a bio-accumulator — which means it has the tendency to absorb compounds from the soil and accumulate them in its leaves, stems, and roots. The deep taproots of the hemp plant stretch far beneath the soil, pulling out and storing all the heavy metals and other elements it can find in the soil.

This aspect is in part why hemp is so nutritious, but it also means that plants grown in contaminated soils often contain contaminants that can be harmful to your health. Some of the worst offenders are heavy metals — which can build up in the body over time and lead to severe long-term health effects.

You want to avoid consuming heavy metals at all costs.

Poorly grown hemp could contain heavy metals, as well as other contaminants like mycotoxins, or pesticide residues that will end up in the CBD oil after all the processing is complete.

For this reason, it’s important to purchase CBD oil from companies that account for this effect. Only buy from company’s that make an effort to source hemp from organic farms, and take measures to assess every batch of hemp that enters the facility to determine heavy metal, microbial contaminant, and pesticide contamination.

The best hemp sources tend to come from states like Oregon, Colorado, or Alabama, as well as neighboring countries like Canada or Scandinavian countries. These places are all known for having high standards for hemp cultivation, and clean soils.

2. Look for CO2 Extracted Products

Once the company has the hemp, they need to extract the CBD from it. You can do this in many different ways using solvents like ethanol, methanol, hexane, ether, or butane. All of these solvents work to strip the active compounds from the hemp plant and can then be evaporated to leave behind a pure CBD-rich resin.

however, there’s a problem with these solvents.

Even in professional lab settings, it can be very difficult to remove all traces of these solvents from the final product. Most of these solvents are toxic to the human body, even in trace amounts.

Therefore, the best companies are using another method to strop the active ingredients from the starting hemp material. This method uses CO2 placed under high pressure. the high pressure and temperature control convert the CO2 into a phase that’s neither liquid nor gas. This special state is referred to as being supercritical.

Supercritical CO2 acts just like any other solvent, but with one key benefit — as soon as the pressure is relieved, the gas evaporates completely, leaving behind no harmful chemical residues.

when shopping for CBD oil, it’s ideal to look for a company that uses supercritical CO2 to extract the CBD rather than the toxic solvents mentioned above. Supercritical CO2 is very expensive and highly technical — but usually produces a far superior product in the end.

If a company is using harsh solvents like butane or propane (or they don’t tell you anything about their extraction methods), it’s a sign that you should look for another brand.

3. Ask for Third-Party Lab Reports

Every company has the option to send their products to an independent lab or third-party testing.

These laboratory tests check for the entire cannabinoid profile of the extract and are able to detect over 200 common contaminants.

Before a CBD product becomes available for sale, it should pass the laboratory test for potency and purity. If any inconsistencies are shown between different batches of the same product, the company should rework it and send it for analysis once again.

High-quality CBD companies will continually send each batch of product to a lab with no affiliation to the company (called a third-party or independent lab) for testing. These results are then published publicly on the website for customers to view.

The best companies will take this even one step further — adding a database and batch numbers on every bottle of CBD oil so you can view the results for your specific bottle of oil. Third-party testing is now an industry standard.

Always buy your CBD oil from companies that show third-party lab reports on their website. Only then will you know what’s inside the bottle before you even order a product. If the company is producing CBD oil that’s as high quality, as they say, there should be nothing to hide in these lab tests and they should be listed publicly on the company website. If you can’t find them on the site, you can ask customer service for these as well.

If these tests don’t exist, or you can’t track them down from the website or customer service — it’s best to avoid this company and move on to another that takes this important step seriously.

What the Research Says About Using CBD Oil for Pain:

Understanding how CBD works is no simple task. This compound is incredibly complex — working through a number of unrelated receptors around the body, interacting with enzymes, cell membranes, and various other cell structures. This makes studying CBD very difficult.

Nevertheless, there have been thousands of research papers published on medical marijuana — seeking to understand the interaction between cannabinoids like CBD and the human body. A lot of this research specifically focused on the effects of CBD on various forms and causes of pain. Let’s explore some of the results this research has yielded in the context of pain management.

1. CBD Oil for Chronic Back & Nerve Pain

The painkilling properties of cannabidiol have been most thoroughly studied in animal models, as well as a handful of human clinical trials.

One of the best studies we have available on the topic is a meta-analysis published in 2017. This analysis looked at 24 different clinical trials involving 1,334 patients over several years and demographics. These studies all used various forms of cannabis for treating chronic pain. The analysis reports that many of these studies showed a reduction in chronic pain scores by 50% or more (3) — suggesting the cannabis plant to be a potential treatment for chronic pain.

Another clinical trial looked at the effects of a combination of CBD to THC in the treatment of intractable cancer pain. This study found that twice as many people in the treatment group given CBD and THC had a 30% or more reduction in pain symptoms at the conclusion of the trial (6).

Even though more clinical trials on humans are needed to gauge how CBD affects specific forms of pain or other conditions, scientists believe the efficacy of CBD in treating chronic pain is related to its anti-inflammatory effects (3).

2. CBD Oil for Arthritis

CBD has had a lot of research as a potential alternative to prescription and non-prescription pain medications commonly used for alleviating arthritis pain.

Researchers have found a clear link between the endocannabinoid system and the pathophysiology of osteoarthritis, which is a degenerative joint disease associated with chronic pain and inflammation (4).

One of the key areas CBD is thought to support osteoarthritis specifically is through the effects on an enzyme known as 5-lipoxygenase — AKA 5-LOX. CBD has been shown to inhibit this enzyme (7), which converts fatty acids into pro-inflammatory compounds. These inflammatory messengers have been shown to be a key component in the underlying inflammation involved with osteoarthritis (8).

By reducing the underlying causes of arthritis pain, CBD is thought to reduce the overall burden of pain from the condition over the long term.

3. CBD and Multiple Sclerosis (MS) Pain

Due to its antioxidant and anti-inflammatory properties, CBD is a potent neuroprotective — which is how experts believe CBD is able to relieve debilitating MS pain, —which affects roughly 50–70% of patients diagnosed with the condition.

A study conducted on animals at Cajan Institute tested the anti-inflammatory effects of CBD on mice the researchers wanted to find out if CBD can provide a reversed inflammatory response on those cells. After ten days, the researchers found a reduction in inflammatory markers with a rodent encephalitis model designed to imitate the impact MS has on the body (5).

More research is needed to see exactly how these effects are translated to humans. Currently, there are 23 clinical trials currently underway, or planned within the next 12 months seeking to explore the effects of CBD on MS.

4. CBD Oil in Sports: Injuries & Muscle Endurance

Cannabidiol can be applied in two different ways when it comes to pain and physical activities. For example, when you administer CBD orally in the form of oil as a post-workout, it helps alleviate the muscle inflammation that troubles athletes once they go beyond the edge again.

If, however, you’re suffering from an injury, it’s best to apply CBD topically. Its anti-inflammatory and neuroprotective properties allow the cannabinoid to relieve pain and improve regeneration capacities.

Does CBD Have Any Side Effects?

The main reason why parents are so enthusiastic about CBD is that this cannabinoid is completely non-intoxicating, doesn’t cause addiction, and has only a few mild side effects when taken at excessive doses.

Research shows that even doses up to one and a half grams have no severe side effects on human health (9).

Despite being a notoriously safe supplement, there are some side effects of using CBD in high doses. Let’s cover the most common side effects people report from using CBD:

  • Anxiety
  • Brain fog
  • Reduced appetite
  • Mood changes
  • Diarrhea or constipation
  • Dizziness or lightheadedness
  • Drowsiness or fatigue
  • Dry mouth
  • Nausea and vomiting

The most common side effect by far, like other forms of cannabis, is dry mouth. This is best managed by taking your CBD oil along with some juice like pineapple or orange juice.

Another common side effect is lowered blood pressure, which may trigger another unwanted reaction — lightheadedness. This side effect is important to consider if you suffer from low blood pressure already or are taking blood pressure-lowering medications.

Always consult your doctor before using CBD or other cannabis extracts if you’re taking prescription medications or have underlying medical conditions.

In Summary: Buying CBD Oil For Pain

As CBD becomes more popular around the world, scientists are publishing new research on cannabinoids on a near-weekly basis. As time goes on, experts are mapping out the complicated mechanisms CBD and other hemp derivatives are using to support both acute and chronic pain of all different origins.

Here are the main takeaways from the current research:

  • CBD inhibits inflammation at several different levels
  • CBD offers antioxidant support
  • CBD may relieve muscle tension and inflammation
  • CBD interacts with the vanilloid receptors in the brain responsible for regulating inflammatory pain transmission

When it comes to pain, CBD appears to target the cause of the problem instead of just masking its symptoms.

Getting relief on so many levels and without any harmful side effects or risk of addiction is the reason why CBD oil has become so popular over the past half a decade.

I hope this guide has managed to clear up any confusion regarding CBD oil and pain, and given you the insight necessary to find the right CBD oil for the job.

Have you tried CBD oil for chronic pain? Did you feel any difference? Let me know in the comments below!


  1. Brand, E. J., & Zhao, Z. (2017). Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?. Frontiers in pharmacology, 8, 108.
  2. Alger B. E. (2013). Getting high on the endocannabinoid system. Cerebrum: the Dana forum on brain science, 2013, 14.
  3. Aviram, J., Samuelly-Leichtag, G. (2017) Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Physician, 20(6), E755-E796.
  4. Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules (Basel, Switzerland), 23(10), 2478.
  5. Elliott, D. M., Singh, N., Nagarkatti, M., & Nagarkatti, P. S. (2018). Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells. Frontiers in immunology, 9, 1782.
  6. Johnson, J. R., Burnell-Nugent, M., Lossignol, D., Ganae-Motan, E. D., Potts, R., & Fallon, M. T. (2010). Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain. Journal of pain and symptom management, 39(2), 167-179.
  7. Takeda, S., Usami, N., Yamamoto, I., & Watanabe, K. (2009). Cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metabolism and Disposition.
  8. Lascelles, B. D. X., King, S., Roe, S., Marcellin‐Little, D. J., & Jones, S. (2009). Expression and activity of COX‐1 and 2 and 5‐LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Journal of orthopaedic research, 27(9), 1204-1208.Chicago
Nina Julia

Nina created following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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Best cbd oil for sciatica nerve pain

7 Best CBD Oils for Nerve Pain

This article contains affiliate links to products. We may receive a commission for purchases made through these links.

Did you know that CBD oil is a natural and safe method of treating nerve pain? This article will provide you with information on what CBD oil is and how it can be used to treat various forms of nerve pain. By the time you finish reading this article, you may discover that CBD oil could be an effective treatment for your nerve pain.

What is CBD Oil?

CBD oil, also known as cannabidiol or cannabinol, is a safe and natural herbal supplement that comes from the cannabis plant. Unlike THC (tetrahydrocannabinol), which causes the typical “high,” CBD oil does not produce any psychoactive effect.

In the past few years, there has been a growing interest in this herbal supplement. This is due to the many health benefits of CBD oil, such as its ability to treat various forms of pain and anxiety. In addition, there are other potential medical uses for CBD oil that remain to be studied.

The reason why CBD oil has become so popular over the years is largely due to the fact that it does not produce any dangerous side effects. The reason behind this is that, unlike other drugs and supplements, CBD oil comes from natural cannabis plants instead of chemical laboratories. As a result, there has been no evidence to suggest that CBD oil can lead to any harmful or uncomfortable side effects.

What is nerve pain?

Nerve pain, also known as neuropathic pain, is an umbrella term for various types of chronic pains. These can include burning, stabbing, and tingling types of pain that are felt due to nerve damage. Neuropathic pain can be caused by conditions such as shingles or diabetic neuropathy.

It should be noted that not all nerve pains are the same, and each type of pain is unique in its own way. For instance, some types of neuropathic pain may be caused by injuries to the nerve. One such example would include when a patient’s sciatic nerve is injured due to a herniated disc.

Other types of nerve pain, such as that from diabetic neuropathy, are caused by increased sugar levels that start to damage the nerves. As a result, many people who suffer from diabetes develop this condition because of long-term nerve damage.

In some cases, neuropathic pain may be due to the development of small masses on or around the spine called tumors. In addition, it can also be caused by various drugs, such as anti-convulsants.

What are the symptoms of nerve pain?

As mentioned above, there are several different types of neuropathic pain. Therefore, each type will have its own set of symptoms that can vary from patient to patient.

For instance, most people who suffer from sciatic nerve pain will complain about a sharp and intense pain that starts from the lower back and goes down to their feet. In severe cases, this form of nerve pain can even extend to the legs.

Other symptoms include numbness or tingling in any area where the sciatic nerve is located as well as an overall sense of weakness in both legs.

In some cases, patients with diabetic neuropathy will report a tingling sensation in their legs and feet. In most cases, this condition will also include unexplained weight loss, fatigue, and slow-healing sores on the legs or feet.

How can CBD Oil Help Treat Nerve Pain?

CBD oil has shown to have several benefits that can help treat patients who are suffering from nerve pain. For instance, CBD oil has been proven to be an effective anti-inflammatory agent, which is why it is often recommended for people who suffer from arthritis.

Additionally, many studies have found that the use of CBD oil may also offer neuroprotective effects. The reason for this is that CBD oil has been shown to promote the growth of new nerve cells, therefore promoting healthy and functional nerves in patients who suffer from neuropathic pain.

In addition, CBD oil has also been proven to help control neurotransmitter release, which can help regulate pain levels when they become too high.

Another benefit associated with CBD oil is that it can reduce chronic pain and inflammation. This means that CBD oil may be an effective treatment option for those who suffer from conditions such as arthritis and diabetes.

CBD oil has also been proven to help improve sleep quality, which is why many patients with nerve pain often experience insomnia. In some cases, such as when a patient is struggling with insomnia, CBD oil can help improve their quality of sleep.

Although there are various types of medications that can be prescribed to patients who suffer from nerve pain, many people prefer natural remedies like CBD oil.

CBD Oil Uses for Nerve Pain

It seems that CBD oil is a very promising and effective treatment of nerve pain. There are various different types of nerve pain, including:

Phantom limb pain.

This occurs when an individual has lost a limb and continues to feel the presence of that limb even though it’s gone.

Trigeminal neuralgia.

This is a condition that causes extreme facial pain.

Postherpetic neuralgia.

This is the most common type of nerve pain that occurs after an outbreak of shingles. It typically occurs in older people who are more vulnerable to this type of infection.

Diabetic neuropathy.

Although there are several different types of nerve pain, CBD oil seems to be a very promising and effective treatment of nerve pain.

In addition, CBD oil has been proven to have several benefits that can help treat patients who are suffering from nerve pain. For instance, CBD oil has been proven to be an effective anti-inflammatory agent, which is why it is often recommended for people who suffer from arthritis.

Although there are various different types of medication that can be prescribed to patients who suffer from nerve pain, many people prefer natural remedies like CBD oil. In addition, CBD oil has been proven to have several benefits that can help with nerve pain.

More about the 7 best CBD oils for nerve pain:

1. Penguin CBD

Image courtesy Penguin CBD

Looking to add some pep in your step? Introducing Penguin CBD, a natural hemp extract made with refreshing mint, citrus, strawberry, and cookies & cream flavors. Packed with Omega-3s, vitamins, and minerals, Penguin CBD oil is perfect for rejuvenating your body and mind.

2. Everest

Image courtesy Everest

You deserve the best, and that’s why Everest CBD offers the highest-quality Delta-8 THC Oil on the market. Their oil is vegan-friendly, GMO-free, and dairy-free. It’s also pesticide-free, ensuring that you’re getting a product free of harmful chemicals. With every 30 ml bottle packing 1000 mg of Delta 8 THC, this oil is perfect for anyone looking for help with their nerve pain.

3. Verma Farms

Image courtesy Verma Farms

CBD oil is all the rage these days, and for good reason—it can provide relief from a variety of issues. Verma Farms takes things one step further, though, by ensuring their CBD oil is organic, GMO-free, and pesticide-free. Plus, it’s distilled to preserve cannabinoids, meaning you get a pure dose of CBD with no unexpected THC.

4. R+R Medicinals

R+R Medicinals is quickly becoming one of the most trusted and popular CBD brands by proving one thing – they make the CBD that works. Using supercritical CO2 extraction on their proprietary Cherry strain of USDA Certified Organic hemp, they yield an unparalleled profile of cannabinoids, terpenes, and other phytonutrients in their products that translate into guaranteed performance.

5.Koi CBD

Image courtesy Koi CBD

Looking for a reliable, cannabis-based source of CBD? Koi Natural has you covered. With years of experience in the industry, Koi is a member of various reputable CBD organizations and uses only U.S. grown hemp to make its products. From tinctures to topicals, Koi has something for everyone.

6.Joy Organics

Image courtesy Joy Organics

This is a company started by a woman who knows what it’s like to suffer from pain and sleep issues. After trying CBD and finding relief, Joy decided to create her own line of products, and today, those products are some of the best-selling on the market.

Our organic, broad-spectrum CBD is third-party tested and loved by reviewers. Try it today and feel your joy return.

7.Royal CBD

Image courtesy Royal CBD

Royal CBD hemp is cultivated using eco-friendly methods, and all of their products are made without harsh chemical additives. Plus, they use CO2 extraction to get the CBD oil, so you know you’re getting the purest product possible.

What criteria did we evaluate to determine the above 7 best CBD oils for nerve pain?

There are many important factors to consider when purchasing CBD oils for nerve pain. That’s why we took the liberty to consider the following criteria before adding a CBD oil brand to our list of CBD oils for nerve pain.

The hemp and extraction methods used

The most preferred method of extraction for CBD oil is CO2 extraction. This is where they put carbon dioxide under maximum pressure and low temperatures to help isolate, preserve, and maintain the purity of the medicinal CBD oil. This method is safe and non-toxic, causes minimal ecological impact, and is readily available.

Quality control testing

We only chose CBD oils with “third-party” test results, as these are the most trustworthy. We also didn’t include oils that had harsh chemicals like propylene glycol or denatured ethanol in their ingredients.

Price & Quality

While price shouldn’t be the sole deciding factor when it comes to choosing a CBD oil, it’s an important consideration. We ranked these CBD oils based on quality, purity, potency, and customer feedback. We also added in our ranking that “the price should be low enough to make it affordable for most customers”.

Customer Feedback

We added this as an afterthought to our criteria, but we realized that there’s nothing more telling than the feedback given by real customers who buy and use these products. So, we included this as part of the determining factor for which CBD oils for nerve pain should be featured in our top 7 list.

At the end of the day, our goal is to make it easier for you to find high-quality CBD oils that work effectively in relieving nerve pain. We don’t want it to be more difficult than necessary, which is why we did the research and compiled this list of CBD oils for nerve pain.

How to use CBD Oil for Nerve Pain Relief

When it comes to finding relief for nerve pain, there are a number of options. CBD oils, however, work with the body’s endocannabinoid system to relieve symptoms fast and easy.

Here is an outline of how you can use CBD oil for nerve pain:

Pick your preferred method.

There are several ways that you can take CBD oil for nerve pain. The five main ways are sublingual, oral, topical, vaping, and ingestion. Sublingual allows the CBD to be absorbed through your mouth where it enters directly into your bloodstream.

Choose your preferred CBD oil.

The benefits of using CBD oils for nerve pain are numerous, but it’s important to choose an oil that works well for you. You can try one or all seven of these best CBD oils for nerve pain relief if necessary.

Start small.

Regardless of the CBD product you use, it’s always smart to start small. This method of using CBD oil for nerve pain allows you to gauge how it works, and whether or not it will be effective in reducing your symptoms.

Don’t give up on relief if the oil doesn’t work right away.

Some people don’t see immediate results after trying CBD oils for nerve pain. However, if they keep using the oil, they eventually experience long-term relief.

Tips for Taking CBD Oils for Neuropathy

Being that there are many methods in which to get your CBD oils for nerve pain, we wanted to share tips on each method. Below you’ll find tips to help you enjoy your CBD oils for maximum nerve pain relief.

Use CBD Oil Tincture

It’s easy to take CBD oil tincture for nerve pain. Start by placing a drop under your tongue using the dropper that comes with the bottle. Hold for 30 seconds, then swallow up to three times daily.

Apply CBD Oil Topically

You can apply pure or full-spectrum CBD oil topically on areas of your body where you feel pain. Just a word of caution; CBD oil is a powerful product and should only be applied topically in small amounts to avoid irritation.

Take CBD Oil Edibles

You can eat CBD oil edibles for pain relief for many different reasons. If you don’t like vaping or oils, this is another option that you can try. Start by adding a few drops of the oil onto your favorite dessert or candy and ingest as normal.

Will CBD oil make me high?

No, CBD oils won’t make you high since the THC level is 0.3% or below in most states. The “high” that you feel when using CBD oils for nerve pain comes from the oil’s ability to reduce inflammation and relax your body and mind.

Can CBD oil help shingles nerve pain?

Yes, CBD oils can relieve shingles nerve pain fast. Many studies have shown that using CBD oil for shingles nerve pain can help reduce inflammation and the risk of flare-ups.

Can CBD oil help with shoulder pain?

Yes, CBD oils can help relieve shoulder pain by reducing inflammation and stimulating your body to release endorphins. Endorphins are neurotransmitters that reduce your perception of pain and promote a general sense of well-being.

Are CBD oils good for arthritis?

CBD oils for nerve pain can also treat inflammation from arthritis. Just like with shingles and shoulder pain, CBD oils reduce inflammation in the affected area which helps to relieve discomfort.

Is CBD oil safe?

Yes, CBD oils for nerve pain are safe because they don’t activate the CB1 or CB2 receptors in your brain which makes them non-psychoactive. They contain no THC which means you won’t feel high from using them.

How to stop taking pain medications with CBD oil

If you’ve been taking opioids, antidepressants, certain medications for anxiety or insomnia, you may want to talk to your doctor about whether you should reduce or stop the use of these drugs when using CBD oil for nerve pain.

Taking CBD oil for nerve pain doesn’t mean you have to stop using other treatments. However, it’s important that you don’t increase your dosages of any medications when starting on CBD oils.

Again, make sure to talk to your doctor and work closely with them as you start using CBD oils for nerve pain.

CBD Oil Side Effects

There are minimal side effects from taking pure CBD oil. You may feel drowsy since it’s an anti-inflammatory, which means you won’t feel high from using it.

You could develop a dry mouth due to dehydration, but this is easily fixed by drinking plenty of water throughout the day. CBD oils for nerve pain are a natural way to treat shingles, arthritis, shoulder and back pain.

What strength CBD oil for nerve pain is best?

It depends on the strength of your pain. The higher the THC level, the more intense the CBD oils will be. For chronic pain and nerve conditions like shingles, we recommend using something that will provide long-term relief with a lower THC level.

Of course, all of this is dependent upon finding a pure CBD oil that doesn’t have any synthetic additives or extra ingredients. You can find what you’re looking for at Penguin CBD or Everest.

The Best CBD Oils for Nerve Pain

What’s the best way to take CBD oil for nerve pain in the face?

You can take CBD oil for nerve pain in the face using a CBD lotion or spray that you apply topically. You can reapply as needed throughout the day, but make sure to keep it away from your eyes.

How long does CBD oil take to work on shingles?

CBD oils for nerve pain should start working within 1-2 hours. The more you use them, the better they’ll work and the longer it will take before your acute symptoms start to subside.

How long does CBD oil last?

It depends on how much CBD oil you consume and what strength it is. It’s important to always follow the instructions on the bottle and to not consume more than directed.

How to store CBD oils for nerve pain?

CBD oils should be stored in a cool, dark place and away from children to protect them from possible harmful effects. Always check the expiration date before you buy CBD oils for nerve pain so you know how long you have before they expire.

With all of this information in mind, it’s easy to see why CBD oils for nerve pain are so popular among those experiencing chronic pain. The safety profile of these products is unmatched by other types of medications that are often prescribed to people with nerve injuries or other serious conditions.

Since they contain no THC, you won’t feel high or groggy when using CBD oils for nerve pain. Some brands even offer lotions and balms that are meant to be applied directly to the area of your body where you’re feeling discomfort. Just make sure that it’s legal in your state before purchasing CBD oils online since some states require a prescription to use them.

In conclusion, CBD oils are a great way to relieve pain, inflammation, and other symptoms associated with nerve injuries or conditions. If you’re looking for a natural way to treat your pain, CBD oils may be the right choice for you.

CBD for Sciatica: Here’s what you need to know

The sciatic nerve runs throughout the lower back and the legs, and when it is pushed too hard or rubbed the wrong way, it can cause terrible pain over a vast area.

There are many causes of sciatic pain, from herniated discs to bone spurs in the spine. Any of them can be complicated by factors such as obesity, passive lifestyle, advanced age, and diabetes.

As a chronic pain issue that impacts everyday life, people with sciatica have limited options. Painkillers and over-the-counter meedications are only so effective, not to mention potentially harmful. Many patients seek out alternative treatments, including CBD products such as oils and topicals.

In this post, we explore whether CBD can help with the management of sciatic pain, and provide our opinion on the best CBD brand for sciatica in 2020. We’ll talk about what sciatica is, who gets it, how it feels, and how CBD can work to treat it. We’ll explain why we like Spruce CBD generally and why we like Spruce CBD oil and Spruce CBD salve as complementary therapy for sciatica.

What Is Sciatica?

Mayo Clinic describes sciatica as a painful sensation radiating from the sciatic nerve. The sciatic nerve originates in the lower back and branches through the hips, buttocks, and legs. Obviously, this means aggravation of the nerve and sciatica can cause hip pain, leg pain, or back pain—and all of these symptoms of sciatica typically occur on one side of the body.

These factors make sciatica confusing. For example, it can seem like a localized injury on one side. But what’s really going on in each case—whether it’s a herniated disk, bone spurs (hard bumps forming on the spine), or spinal stenosis (a narrowing of the spine)—is compression of the sciatic nerve causing pain, numbness, and tingling in affected areas.

Sciatica can also cause regular motion to feel much more difficult because the feet and legs feel weak. Even the sudden movements caused by normal motion from coughing or sneezing can exacerbate sciatic nerve pain as motion shakes the nerve.

Although sciatica can last a very long time, in most cases, sciatica is a temporary condition lasting between four to six weeks.

A slipped disc from an injury is the most common cause of sciatica. When the soft tissue between other bones and the spine is moved out of place, a slipped disc can occur. This can lead the spine to push against the sciatic nerve causing sciatica.

It is difficult to treat slipped discs because they don’t typically go back in place or heal well on their own once they become dislodged from their original position beneath the vertebrae. As a result, a slipped disc often leads to chronic, frustrating conditions that can include intense, day-to-day pain.

Spinal stenosis, the narrowing of the spinal canal and resulting compression of spinal cord nerves, is another very common cause of sciatic nerve pain. Spinal stenosis is frequently mistaken for general leg or back pain and typically occurs in older people.

Spondylolisthesis, a problem that causes the vertebrae to slip out of place, causing friction between the bones and the sciatic nerve, can also trigger sciatica. Spondylolisthesis is one of the leading causes of lower back pain, and many people do not realize they have it.

When protective discs that offer padding between the spinal cord and bones start to break down, it can cause discomfort and pain from pressure on the sciatic nerve. This is called degenerative disc disease, and it is another cause of sciatica.

Who is Likely to Suffer from Sciatic Pain?

Sciatica is, at a minimum, irritating. Just coughing or sneezing can be enough to trigger pain. Severe sciatica can cause intense pain that compromises ability to function, let alone perform.

Risk factors for sciatica include:

  • Aging. Over time, the body’s discs become damaged and stressed. The sciatic nerve becomes irritated as bone spurs develop.
  • Sedentary lifestyle. People such as office workers who sit for long periods of time are more prone to sciatica. This is because without the relief it gets from intermittent movement, the spine is under pressure for too long just from being held still. Mitigate this issue by using a high quality chair and getting up to take breaks frequently.
  • Certain jobs. Some jobs are more likely to place extra stress on the spine or create injury by requiring the worker to carry heavy loads, twist their back, or otherwise perform risky tasks.
  • Overweight. Carrying too much weight pressures the spinal cord and may trigger sciatica.

Of course, many people are susceptible to multiple risk factors. For example, someone who is overweight, doesn’t get much exercise, is older, and suffers from diabetes is at high risk for sciatica.

This is even more true if they work in a job involving heavy physical labor—particularly if they lead an otherwise passive lifestyle. Whether you’re sitting at a desk for eight hours at a time or engaging in repetitive motions, sciatic nerve pain is more likely to develop in people who work these types of jobs.

My Sciatica Issues: From One of Our Testers

As a kid I remember watching my grandmother struggle to stand up, grabbing her hip in pain. Later, as a young adult, it was my aunt who was suffering from sciatica. Now it’s me.

I’ve been coping with sciatic pain for about ten years now—since my late 30s. At first that shooting pain down my leg and back was just startling. Now it’s a serious problem, and some days I’m hunched over like an oldster.

I don’t have health insurance, but even if I did, I’m familiar with the traditional routine because my aunt went through it for years (and she still is). Cortisone shots last for a few weeks—and they don’t feel great going in, trust me. They’re still the best thing going, but they are less and less effective.

Muscle relaxers are a non-starter. They don’t work and make you gorked out. Stretching and yoga are excellent, but they can’t put a stop to sciatica pain that is already there. (Do them anyway!)

That’s why CBD is a really useful tool in the sciatic pain relief toolbox.

How Can CBD Help Relieve Symptoms of Sciatica?

Neuropathic pain is the kind that irritation, inflammation, or neural tissue compression causes. Nociceptive pain is triggered as the body reacts to painful stimuli, such as when the inflammatory response is triggered, and it does not itself cause nerve damage.

Sciatica generally causes both neuropathic and nociceptive pain, and research indicates that CBD can alleviate both types.

Cannabidiol or CBD is a critical part of the endocannabinoid system (ECS), binding with the CB1 and CB2 receptors to send signals about conditions and restore homeostasis or balance in your body. In this role, CBD and other cannabinoids fight pain and inflammation, and therefore can help treat sciatica and other health issues.

Research has already proven that CBD is a potent analgesic and anti-inflammatory. Specific research also seems to support the idea that CBD can treat neuropathic pain—and this is certainly an element of sciatica. The remaining inflammatory response is also something that CBD can treat, as research indicates.

So, although no study has directly investigated the effectiveness of CBD in treating sciatic pain in humans, there is ample anecdotal evidence and plenty of suggestive science out there to make trying it a sound idea.

CBD oil will not cure sciatica; it doesn’t address the underlying issues such as compression of the sciatic nerve. However, its pain-relieving and anti-inflammatory properties can alleviate some of the worst symptoms.

Conventional therapies for sciatica include anti-inflammatory drugs such as ibuprofen, aspirin, naproxen, and other over-the-counter painkillers. Doctors also recommend ice or hot packs and physical therapy.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a popular choice, but they only relieve nociceptive pain and inflammation, not neuropathic pain. In contrast, CBD oil has proven to have anticonvulsant and antidepressant benefits in addition to its anti-inflammatory properties.

Pros and Cons of Using CBD to Treat Sciatica


  • Safe. CBD has a very high safety profile and is well-tolerated by humans, even at high doses of as much as 1500mg daily.
  • Legal. Thanks to the 2018 Farm Bill, it is legal to produce and sell hemp-derived CBD oil, despite the fact that the US Food and Drug Administration (FDA) still has yet to meaningfully regulate the area or acknowledge that hemp-based products have therapeutic qualities.
  • Easy. It is simple to find CBD products over the counter without a prescription, in contrast to medical marijuana products, which require some kind of authorization except in recreational states.
  • Variety. CBD is available in a huge range of products, from gummies to tinctures, topicals, and vapes.


  • Side effects. CBD oil has a few minor side effects despite its high safety profile, including dry mouth, fatigue, and appetite changes.
  • Interactions. If you take prescription medications, you should always talk to a medical practitioner before supplementing with CBD because it may interact with some medications.
  • Uncertainty. The research in support of CBD as sciatica treatment remains inconclusive.

What Types of CBD Work Best for Sciatica: CBD Oil or CBD Topicals?

This is a good question, although to a very real extent this will vary somewhat from person to person. Pain management is very personal. Still, there are a few ways to consider how to identify the best CBD for sciatica in your case:

Full-spectrum CBD and the entourage effect

CBD products may offer full-spectrum CBD, broad-spectrum CBD, or CBD isolate. Full-spectrum CBD retains all of the naturally-occurring phytonutrients from the hemp plant. This enables full-spectrum CBD products to produce the entourage effect, the result of multiple terpenes and cannabinoids working together in synergy to create greater benefits and/or function more efficiently.

The entourage effect is still produced by broad-spectrum CBD to some extent, but broad-spectrum products lack the trace amounts of THC that full-spectrum extracts retain. CBD isolates remove all other terpenes and cannabinoids, somewhat reducing the effectiveness of the CBD—so these products are best for people who regularly get tested for drugs.


Lame as it is, there are still some states that place limits on even hemp-derived CBD products, including where they can be bought and how they are labeled. Since marijuana-derived products are regulated far more strictly, stick to hemp-based CBD products.


Buy CBD products from reputable brands. If you are shopping around, look for organically-grown hemp from the US and CBD products made with the heatless and solventless supercritical CO2 extraction method.


Look for CBD products that are independently tested for content analysis by a third-party laboratory. Reputable companies post lab reports online or make them available so you can see the potency of CBD and verify that the product is free of any contaminants and dangerous substances.


Read real customer reviews. Focus on third-party websites and blogs on the use of CBD, not just product websites. Explore flavor options or CBD capsules if you dislike the naturally bitter taste of hemp. Are you hoping for a topical or tincture treatment option? Something different like a vape or CBD gummies?

For sciatica, CBD topicals, such as CBD salves, creams, lotions, and gels, can treat localized pain and discomfort in the lower back, buttocks, hips, and legs. Another excellent option is CBD tincture or oil sublingually twice a day.

Our Favorite CBD for Sciatica

Our favorite brand for treating sciatica? Spruce—and we like to hit it with a one-two punch of CBD oil in the form of 2,400mg Max Potency Full Spectrum CBD Oil Tincture and CBD topical in the form of Spruce 2,000mg Full Spectrum CBD Salve. Here’s why Spruce generally:

Quality. Spruce sources all of their hemp from family-owned Kentucky and Colorado farms known for sustainable, safe farming processes. These growers offer some of the highest potency and quality hemp and cannabis strains available for use for CBD consistently.

Process. Spruce extracts CBD using a unique technique with moonshine as a solvent to create a high-quality blend of high-CBD, low-level THC hemp seed oil. To ensure that there is zero aftertaste or effects from the moonshine, it is completely filtered out before bottling.

Purity. All Spruce CBD products are guaranteed to be free of harmful pesticides, chemicals, and heavy metals, and are tested by an independent third party laboratory to prove it. Lab testing information is available on the site.

Service. Spruce ships free within the US and delivers within 2 to 4 days, typically. You qualify for a full refund after your first purchase according to their return policy if you return your purchase unopened according to directions.

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Diamond cbd oil for pets

MediPets CBD Review

Falling under the umbrella of Diamond CBD, a CBD industry leader, MediPets is a pharmacist-formulated CBD brand for pets. The company has an excellent selection of CBD treats for dogs and cats, as well as a line of CBD oils.

*All the data provided is for oil products only

MediPets CBD: Quick Summary

  • Produced by Diamond CBD – a pioneer in the CBD industry
  • Socially conscious brand that uses sustainably sourced hemp
  • Excellent selection of CBD treats for cats and dogs
  • Huge discounts and savings on selected products
  • Lab reports don’t show data on testing for heavy metals, pesticides, etc.
  • CBD oil is unflavored
  • No third-party reviews

50% Coupon Code: CBD50LIFE

MediPets CBD Complete Review

CBD products are becoming increasingly popular, both for humans and pets. Much like for humans, early research suggests that CBD has beneficial effects for pets, too, such as relieving pain and reducing anxiety and depression. It may also be helpful for treating nausea and vomiting, reducing seizures, and supporting bone and joint health.

The CBD for pets industry is booming, with several CBD pet brands on the market.

Today, the CBD for pets industry is booming, with several CBD pet brands on the market. MediPets CBD is a pet product line produced by Diamond CBD, a top-rated CBD retailer specializing in a range of CBD products for humans. The company keeps its CBD pet line completely separate from Diamond CBD, with its own website and branding.

MediPets sells CBD oils and treats for cats and dogs and a CBD spray for dogs. In the below MediPets CBD review, we discuss the company and its product offerings in more detail.

About the Brand and Its Processes

MediPets CBD is a subsidiary of Diamond CBD, who are considered to be CBD industry pioneers. They are a part of PotNetwork Holdings – a holdings company for CBD industry leaders. This speaks volumes to the company’s reputation and credibility in the market.

Diamond CBD’s team is made up of scientists and medical professionals dedicated to crafting pure CBD products without compromising quality. And this enthusiasm seems to follow through to the company’s CBD for pets collection. Although a separate entity, MediPets CBD products are formulated by the same team behind Diamond CBD.

MediPets claims to be the premier provider of top-quality CBD products for cats and dogs in the country. Of course, just about all CBD brands claim to be the best, so do they live up to the hype?

While we didn’t find anything differentiating them from other high-quality CBD pet brands, MediPets certainly strives for excellence. The hemp is 100% natural, organically grown, and sourced from local farms, and all CBD products are pharmacist-formulated. Also, CO2 Extraction is used to remove the CBD and other beneficial compounds from hemp plants.

Additionally, all products are third-party lab tested, and the lab results are available to view on the website. However, the reports only show data on cannabinoids and terpenes. Unfortunately, they’re not as detailed as some other lab reports and don’t show data on heavy metals, pesticides, and other potentially harmful contaminants.

MediPets CBD: The Complete Product Lineup

MediPets offers a full line of CBD oil and treats for pets. They also sell a useful CBD spray for dogs. All products are made using natural ingredients and are free of THC.

Here is an overview of the product lineup.

MediPets CBD Oil

MediPets has a line of CBD oils for dogs, categorized into small, medium, and large dogs. The small dog’s CBD concentration is 90mg, medium dogs 240mg, and large dogs is 600mg. There is only one CBD oil for cats, and it has a total CBD concentration of 90mg. It seems like the 90mg CBD oil for dogs and cats is the same thing – they each contain exactly the same ingredients and CBD concentration.

A vegetable glycerin-based carrier and CBD isolate extract is used to craft these oils. Each comes in a 30ml bottle. The 90mg oils deliver 3mg of CBD per ml, 240mg provides 8mg per ml, and 600mg delivers 20mg of CBD per ml. MediPets asserts that its CBD oil can be added to your pet’s food or drink or administered sublingually, under the tongue.

MediPets CBD Treats

The treats collection is a lot more extensive than the oils. The CBD treats for dogs come in total CBD concentrations of 100mg, 200mg, 300mg, and 600mg and several varieties, including sticks and biscuits. There are also a variety of flavors, like Lamb & Salmon, Beef, Filet Mignon, Meaty Steak, Burger Beef, and a lot more. Just about any treat your dog could want, they’ve got it.

The CBD treats for cats come in concentrations of 100mg, 200mg, and 300mg and delicious flavors, like Seafood Medley, Tasty Chicken, and Meaty Tender Sticks Salmon.

There are tons of treats for dogs and cats, so be sure to check out MediPets website for a complete rundown.

MediPets CBD Spray

Finally, MediPets also sells a CBD Pet Spray. Currently, there is only one offering, and it’s for dogs. It has a total CBD concentration of 100mg and is a full-spectrum formula. It’s unclear how this spray is used; typically, sprays are administered orally. However, a third-party site mentions that MediPets spray can be applied topically, too.

Like the CBD oil, a vegetable glycerin-based carrier is used in the spray – making it very similar to the tinctures. It’s simply a different strength and application method. The company claims that the spray is ideal for long car journeys and other stressful situations.

MediPets CBD Customer Service and Shipping

MediPets ships to all 50 states in the U.S. and offers free 2-day express shipping for orders over $100. The company runs regular sales and promotions, so be sure to check the site often. For instance, at the time of writing, they’re offering 55% off CBD oils for cats and dogs, which is an incredible discount.

The company runs regular sales and promotions and offers free 2-day express shipping for orders over $100.

As for customer service, Medi Pets does not quite meet the standards of some other customer-centric brands. Their return policy is pretty strict – only unopened products can be returned within a 30 day period. There also seems to be a bit of a discrepancy about the return policy on the company website. The homepage states that free returns are available within 15 days of your order, while the return and refund policy tab states that it’s 30 days.

Additionally, we could not find any customer reviews on third-party sites. While not necessarily a bad thing, it makes it difficult to gauge customers’ perception of the brand and its products. But there are quite a few positive reviews under most product offerings on MediPets’ website. However, we don’t focus too much on reviews found directly on brands’ websites because they are not always honest and reliable.

MediPets CBD Review: Summary & Where to Buy

Backed by CBD industry pioneer Diamond CBD, MediPets is a reputable and trustworthy CBD brand for pets. They offer an excellent selection of CBD treats for cats and dogs and also have a decent range of CBD oils for dogs. However, there is only one option when it comes to CBD oil for cats.

The lab testing is not as thorough as it should be, and the return policy is pretty strict, which is a little disappointing. But MediPets certainly seems to be committed to producing high-quality CBD for pets and offers some incredible savings on selected products.

Check out MediPets CBD website for the full product range and prices. The online store is user-friendly, and there is a detailed FAQ section for any questions you may have.

FAQs about CBD Use in Pets

A: Cannabidiol, or CBD, is a cannabinoid produced by the plant Cannabis sativa, commonly known as marijuana. After many anecdotal reports of CBD’s potential health benefits, studies are now underway to look at the potential benefits of CBD for controlling pain from conditions such as osteoarthritis, calming anxious pets, and as a possible treatment for epilepsy in dogs. CBD is being used by many pet owners today, so it’s essential to know enough about it to discuss the potential risks of use.

Q: Is CBD psychoactive?

A: No; however, there are several possible reasons a dog who has ingested CBD may look high:

  1. The product that the pet ingested contains both THC and CBD. There are many products on the market, some even labeled for use in pets, that contain both CBD and THC at varying concentrations, so check the labels or look up the product online to see what’s in it.
  2. The pet ingested enough of a CBD product to cause THC toxicity. Hemp can legally contain up to 0.3% THC, so if a pet ingests a large amount of a hemp-based CBD product, mild THC toxicity can occur.
  3. The product has not undergone quality assurance testing and contains THC.
  4. The dog also found some marijuana or THC edibles. Ask about any other cannabis products in the home.

Q: What are the most common signs reported in pets after the ingestion of CBD products?

A: Vomiting, lethargy, inappetence, and diarrhea are the most common clinical signs reported. Ataxia can occasionally occur with large ingestions.

Q: How do I treat these cases?

A: Most cases need no treatment, aside from symptomatic care for gastrointestinal upset if it occurs. If it’s a large dose, where the THC content might be a factor, mild sedation, urinary incontinence, hyperesthesia, and ataxia could develop, and the pet should be confined to prevent injury from misadventure. If you see significant signs that look like THC toxicity, treat the pet in front of you and provide IV fluid support, anti-nausea medication, and good nursing care as needed.

Q: Is there anything special I need to know about pet hemp treat overdoses?

A: Products sold as “soft chews” can have an osmotic effect when large amounts of chews are ingested and pull fluid from the body into the gastrointestinal tract. In mild cases, this can lead to diarrhea and dehydration. In severe cases, hypernatremia, hyperglycemia, hyperkalemia, azotemia, and acidosis can occur. Aggressive fluid therapy, while monitoring hydration status and electrolytes in these pets, is critical.

Q: What about interactions with other medications? Any long-term effects to be concerned about?

A: CBD is an inhibitor of cytochrome P450 and has the potential to affect the metabolism of other drugs. While this appears to be of minimal clinical significance in most cases, this may be important when CBD is used in a pet for seizure control. Doses of other anticonvulsants may need to be adjusted. Remember that owners may discontinue anticonvulsants on their own if they feel that CBD is controlling their pet’s seizures, so this is an important discussion to have.

CBD has also been shown to cause dose-dependent elevations in liver enzymes in various safety studies. This has not been noted in acute overdose situations but could be a concern in pets taking CBD long-term. Monitoring liver enzymes and total bilirubin in these pets is recommended.

The Best CBD Oils For Dogs

When it comes to alternative treatments for your Bully breeds, CBD has been making a big appearance lately among owners and veterinarians. Cannabidiol, also known as CBD is a compound found in cannabis and hemp plants.

Studies have shown these cannabinoids interact with the endocannabinoid receptors located in the central and peripheral nervous systems, which help maintain balance in the body and keep it in a normal healthy state.

This can have a myriad of health benefits for both humans and pets. CBD has been associated with reductions in anxiety, help with sleep, relief from arthritic pain, and studies are being conducted on it’s effectiveness in reducing epileptic seizures in treatment resistant dogs.

The Top 7 CBD Oil Brands for Bully Breed Dogs

I have spent some countless hours searching the internet trying to find out all I can about CBD oil for my Staffy Ruby. At first glance it can be overwhelming to choose from everything available out there. What kind do I choose? What are the differences in these oils? What dosage will my dog need? How much will this cost each month?

All questions I had, and lucky for you I have compiled all my findings into what I feel are the best brands out there right now. I based the ratings on several competing factors, and it was not easy to choose because these are all top notch products.

All of the products below have passed a few sniff tests right off the jump. They are all brands that have verified 3rd party testing done on their products, all the brands have lab test results available on their website, and all use the CO2 extraction method, which put simply means, there are no solvents used to extract the CBD from the cannabis and hemp plants.

The rankings below are weighed on extraction type, carrier oil type, overall selection, pricing, and refund policies. Further explanation on extraction and carrier oils at the bottom of the post.

#1 – Holistapet

Holistapet brings the absolute top notch CBD oils to the table. Organic, Non-GMO ingredients, diligent care to the quality of the hemp plants, and a customer focused approach to everything they do. Tons of information on their website.

  • Full Spectrum CBD + other Cannabinoids – Hemp Seed Oil Carrier.
  • A large selection of CBD strengths ranging from 150mg – 3000mg.
  • Large assortment of treats, chews, capsules and topicals available.
  • Great pricing, especially for subscriptions. 25% off plus FREE SHIPPING.
  • $1.73/ml – 150mg = $25.95
  • $2.66/ml – 300mg = $39.95
  • $1.95/ml – 600mg = $58.95
  • $2.66/ml -1200mg = $79.95
  • $2.41/ml -3000mg = $144.95
  • Excellent 100% money back guarantee within 30 days.

#2 – Diamond CBD

Diamond CBD is a premium CBD oils company with industrial hemp oil carriers earns it the #2 spot. They carry a great selection of products, and have a unwavering dedication to organic, non GMO, top quality ingredients.

  • Full Spectrum CBD – Hemp Oil Carrier
  • A HUGE selection from 25mg – 550mg.
  • Good assortment of oils, treats, and sprays available.
  • Great pricing, and an excellent subscription discount of 40-60%.
  • $0.50/ml – 25mg = $14.99
  • $0.66/ml – 50mg = $19.99
  • $0.83/ml – 100mg = $24.99
  • $1.00/ml – 150mg = $29.99
  • $1.16/ml – 250mg = $34.99
  • $1.33/ml – 350mg = $39.99
  • $1.50 ml – 550mg = $44.99
  • FREE SHIPPING on orders over $100. FREE SHIPPING on Subscriptions

#3 – cbdMD

cbdMD takes the number 3 spot again to the HUGE selection of fairly priced products available, great subscription model, and rigorous standards to quality. The also carry a CBD peanut butter!

  • Broad Spectrum CBD – MCT Oil Carrier
  • A large selection of CBD strengths ranging from 150mg – 3000mg.
  • Large assortment of oils, calmin oil, hard chews, soft chews, peanut butter, and topicals available.
  • Great pricing, and a pretty sweet subscription price model. Save 30% on first order, 10% off next orders. FREE SHIPPING
  • $0.66/ml – 150mg = $19.99
  • $1.00/ml – 300mg = $29.99
  • $2.33/ml – 750mg = $69.99
  • $3.33/ml – 1500mg = $99.99
  • $4.99/ml – 3000mg = $149.99
  • Excellent 100% money back guarantee within 60 days, and FREE SHIPPING on orders over $79.99

#4 – Pet Releaf

Pet Releaf comes in at #4 with a moderate selection of CBD oil strengths, but a huge variety of products and some really excellent prices. Award winning treats, and impressive certifications. They also carry Lipsome Hemp Oils that provide extra beneficial ingredients like Omega fatty acids.

  • Full Spectrum CBD – MCT Oil Carrier
  • A moderate selection of CBD strengths ranging from 100mg – 500mg.
  • Large assortment of award winning treats, as well as capsules, soft chews, and topicals
  • Excellent prices, with the 10% subscription savings.
  • $0.66/ml – 100mg = $19.99
  • $1.06/ml – 200mg = $31.99
  • $2.16/ml – 500mg = $ 64.99
  • Lipsome Hemp Oils
  • $1.83/ml – 100mg = $54.99
  • $2.66/ml – 300mg = $79.99
  • $2.00/ml – 600mg = $119.99
  • Full refund if not satisfied within 30 days. FREE SHIPPING over $75

#5 – Pet Hemp Company

Pet Hemp Company comes in at #5 with their large assortment of moderately priced, and exceptional quality products.

  • Full Spectrum CBD – Hemp Seed Oil Carrier
  • A large selection of CBD strengths ranging from 150mg – 500mg.
  • Small but high quality assortment of oils, treats, and capsules available.
  • A little higher priced, but still very affordable, especially with the 10% subscription savings with FREE SHIPPING.
  • $2.00/ml – 150mg = $29.95
  • $3.00/ml – 300mg = $44.95
  • $4.33/ml – 600mg = $64.95
  • $2.83/ml -1200mg = $84.95
  • $2.58/ml -3000mg = $154.95
  • Money back within 30 days on unopened products.

#6 – The Anxious Pet

The Anxious Pet earns the #6 spot with its high quality assortment of oil, chews, and supplement bars. A lower selection of products than the above brands, The Anxious Pet still brings premium quality products, and a fair price.

  • Full Spectrum CBD – Coconut Oil Carrier
  • A small selection of CBD strengths in 400mg and 800mg.
  • Small but high quality assortment of oils, chews, and supplement bars available.
  • Fairly priced, with a great subscription option of 15% off with FREE SHIPPING.
  • $1.60/ml – 400mg = $48
  • $2.93/ml – 800mg = $88
  • Amazing 60 day money back guarantee with FREE SHIPPING on all orders.

#7 – Joy Organics

Joy Organics rounds out our Top 7 list with their certified organic Oil and Chew products. Though limited in overall product selection, Joy Organics is dedicated to a premium CBD product and process.

  • Broad Spectrum CBD – Organic Virgin Hemp Seed Oil Carrier
  • A single oil option of 450mg dosage.
  • Small but high quality assortment oil and bacon flavor chew product.
  • Excellent pricing, with a Save 20% and FREE SHIPPING subscription option.
  • $1.79/ml – 450mg = $53.95
  • Satisfaction guarantee 30 day money back refund.

There is a lot of research to be done still in the area of medicinal CBD as to the health benefits and various uses. Anecdotal evidence seems to always point towards it being a great alternative medicine, but it is always good to consult with your vet on the various options available for treatments of your pets ailments.

Further Explainations

Extraction types refer to the 3 different kinds of CBD oil you can create. There is the Full spectrum CBD product contains all the parts of the plant including essential oils, terpenes, and other cannabinoids, such as cannabinol. This is believed to be the best type of CBD as these compounds help in the effectiveness of the CBD. It may also contain trace amounts of THC, but not enough to produce any “high” effects as the amount is so low

Broad spectrum CBD has some, but not all of the plant compounds removed, usually the THC, and can be a little less effective when used compared to Full spectrum. This may require larger doses to reach the same effects.

CBD Isolate is just pure CBD with none of the compounds of the plant remaining. This type of CBD will require a larger dosage, and may still not have the same effect, so I have left all CBD isolate products off my list.

Carrier oils are what is diluted with CBD to deliver it to your dogs system. There are many different kinds, but it is believe that Hemp Oil, or Hemp seed oil are best for absorption, where as MCT oil helps in the preservation of the CBD, but can upset some dogs stomachs.

About Us

Hi I’m Chris and I’ve been working with dogs for over 12 years as a professional dog walker, charity events coordinator, and owner of my two amazing Pibbles. Ruby the Staffordshire Bull Terrier, and Chester the Pocket American Bully.


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How to Take CBD Oil: CBD Drops, Coffees and Cocktails

So, you’ve read all about cannabidiol (or CBD as it’s more commonly known) and now you’re thinking of giving it a whirl. It makes sense. The food and wellness industries are buzzing about this natural chemical compound, which is said to help with anxiety, arthritis, pain relief, menopause symptoms and insomnia to name but a few.

You’ve decided you want to try it, so what’s next? When it comes to how to take CBD oil, you’re spoiled for choice. From tinctures and topicals to smoothies and coffee blends, there’s an overwhelming amount of options out there. Unsure where to start? That’s where we come in – here’s our CBD oil guide to help you decide how best to take CBD oil.

How to take CBD Oil?

While there are many ways to take CBD oil, it depends on the strength of the oil. With our 250mg CBD Oils (a great starting point), you put five CBD oil drops under your tongue and hold them there for 30-60 seconds, and do that three times a day. You can, however, freestyle, putting your drops into a smoothie, juice or even your morning cuppa. CBD is said to take the edge off coffee too.

Which brings us to…

9 Ways to Take CBD Oil at Home

1. In a tincture

In layman’s terms, a tincture is a concoction you take by dropper or spray straight into your mouth. You can take CBD oil by putting it directly under your tongue (that part of the mouth is a capillary-rich area and so the CBD will reach your bloodstream quicker). Try dropping a dose of CBD under your tongue and holding it there for a minute before swallowing.

250mg Natural CBD Oil

250mg Citrus CBD Oil

250mg Peppermint CBD Oil

Natural 1000mg CBD Oil

Natural 2000mg CBD Oil

2. In a capsule

CBD oil also comes in a capsule form, which can be a good option for people who want to maintain a consistent amount of the compound in the body. However when CBD is ingested it passes through the digestive tract which means you might have to wait upwards of 30 minutes before experiencing any effect.

3. In a smoothie

Some blends of CBD oil can have a pungent, earthy taste. It’s not for everyone, which is why many people like to mask the flavour with other – more delicious – ingredients. Another way to take CBD is by adding half a teaspoon of CBD oil to your morning smoothie for a calm start to the day. If you’re after some smoothie inspo, head over to the 5 Best Self Care Smoothies With Hemp .

4. In coffee

If only there was a way to capture the energy of coffee without its associated jitters. Oh wait… there is! There are an increasing number of CBD coffee brands popping up, who claim that when coffee beans are infused with CBD, they take away the anxiety that caffeine consumption can cause. This makes the ‘up’ that your coffee gives you a little smoother; it takes the edge off. Or use a dairy-free milk that’s infused with CBD to easily control your dosage and allow you to continue using your favourite coffee blend.

5. In a salad dressing

Now we’re talking the same language, right? Try incorporating a little CBD oil into your daily cooking routine to get a bunch of health benefits without much effort at all. For a delicious and nutritious salad dressing, start with three to four tablespoons of olive oil, then add two teaspoons of CBD, the juice of half a fragrant lemon and salt and pepper. Here’s 5 hemp oil friendly recipes for starters.

6. In a vape pen

Okay so this one might sound a little scary, but vape pens are easy to use and can go undetected because they produce little smoke. The plus side of taking CBD in a vape pen is that when CBD is inhaled, it enters the lungs where it rapidly passes into the bloodstream. However, it’s important to note that the long-term safety of vaping is still unknown.

7. In sweet treats

The beauty of CBD is that it can basically be baked into anything, which is why you’ll find everything from cookies and brownies to gummies and caramel candies infused with it. Sweets are easy to take along with you in a bag on the go, while baked goods might need to be kept refrigerated to keep the CBD fresh (or just eat them quickly before they go off?).

8. In a topical rub or balm

In balm or rub form, CBD is often blended with fragrant coconut oil or beeswax, which makes it easy to spread on the skin (and makes your bod smell great too). When used topically, CBD can reach local targets, like sore muscles or joints. We’ve also heard it works wonders for period pain.

9. In a cocktail

If you’re feeling fancy go on the hunt for a CBD cocktail. We’ve heard reports that over in San Diego you can order The Mr Nice Guy – that’s a vodka and mezcal mixed drink that includes CBD. More proof, if any were needed, that CBD can be imbibed alongside any other food or drink, and that you’re going to be seeing a whole lot more of it soon.

How Much CBD Should I Take Each Day?

We always suggest starting the day with a few drops – it just sets the tone, you know? But you can top up throughout the day, no problem. Everyone will have an amount that works for them, just play around with it and see what feels good. We recommend starting with 5mg doses, 3 times per day and increasing your dosage incrementally over the course of a few weeks, ensuring you always stay below 70mg each day.

Check out our guide to CBD dosages for detailed advice.

Should I Refrigerate CBD Oil?

No, you shouldn’t. It’s best kept in a dark place like a pantry or cupboard so that it stays cool without getting too cold.

Should I Drink CBD Oil or Rub it Into My Skin?

Whichever you prefer! As outlined above, you can add CBD oil to a variety of different drinks or rub it into your skin as a topical balm. However, rubbing it into your skin tends to be better for sore joints or muscles.

What Does CBD Oil Under the Tongue Do?

This is one of the many ways the body can absorb CBD oil – as we mentioned above, your tongue is capillary-rich, meaning this method will allow the CBD to reach your bloodstream quickly.

How Long Does It Take for CBD Oil to Work on Joint Pain?

It depends on a variety of factors, such as how strong the CBD oil is (the stronger the concentration, the faster you will feel its effects) as well as how you are consuming it. For example, if you are taking CBD oil by placing a few drops under your tongue, it should take effect in around 15 to 45 minutes , while a topical application may take longer.

How Often Should I Take CBD Oil?

This varies from person to person and, when in doubt, you should always consult a doctor. However, we recommend starting with one of our 250mg bottles of CBD and taking five drops three times a day. After you begin to learn how this affects your body, you can better decide whether you should scale your dosage up or down (as long as you don’t exceed 70mg of CBD per day!).

Should I Take CBD Oil in the Morning or Evening?

Again, this is up to you and how CBD oil affects your body. People who find that CBD oil makes them feel energised, awake and clear-headed may prefer to take it in the mornings (or afternoons when they need a bit of a boost), while those who find that CBD oil helps them unwind and relax may prefer to take it in the evenings.

Can CBD Keep Me Awake at Night?

It can, but it probably won’t. While some people do feel that CBD oil makes them feel more alert, preliminary studies have shown that CBD oil is an effective way to treat insomnia.

Have we caught your attention? Now that you know how to take CBD oil, are you interested in trying it out for yourself? Check out our range of Pure CBD oils and start experimenting with your smoothies, baked goods and more!

The “Full-Spectrum” Difference: Why To Look Out For This Term On A Label

Jennifer Chesak is a freelance medical journalist with bylines in several national publications, including Washington Post, Healthline, Prevention, Greatist, Runner’s World, and more. She earned her Master of Science in journalism from Northwestern’s Medill School.

Dr. Bindiya Gandhi is an American Board Family Medicine–certified physician who completed her family medicine training at Georgia Regents University/Medical College of Georgia.

As hemp extract—an extract from hemp plants that’s rich in cannabinoids, including CBD—becomes more popular, it’s starting to pop up in all different forms. One term you’ve likely noticed on hemp supplements, tinctures, and creams is “full spectrum.” Here’s what that means and why it’s important to look out for.


What “full-spectrum” means on a hemp or CBD label.

Full-spectrum hemp oil (not to be confused with hemp seed oil) is an extract only derived from hemp. Hemp is the term for a cannabis plant with 0.3% tetrahydrocannabinol (THC) or less—not enough for mind-altering effects. In contrast, a CBD oil can be extracted from either hemp or marijuana. Marijuana is the term for cannabis plants with higher levels of THC.

Full-spectrum hemp oil contains all of the naturally available compounds the hemp plant has to offer, including CBD and more than 100 cannabinoids and a host of terpenes and flavonoids to boot. This is different from a CBD isolate product that will only contain a single cannabinoid: CBD.

The benefits of full-spectrum oils.

When you take a full-spectrum supplement rather than a CBD isolate product, the hemp plant’s hundreds of compounds have a way of working together to boost the product’s overall benefits. Researchers call this synergy the entourage effect: when cannabis compounds work together, they’re more powerful than any one cannabinoid on its own. “I think about it in a sports metaphor, where you’ve got one star player, but you need the team,” explains renowned integrative physician Robert Rountree, M.D. “It’s the mix that’s important.”

So what are all those compounds, and what do they do? First, cannabinoids affect the body’s endocannabinoid system, the body’s “master regulatory system,” which plays a role in maintaining the immune, digestive, and central nervous systems.

Our bodies actually make their own endocannabinoids to help keep us in balance or homeostasis. But researchers theorize that sometimes we become deficient in endocannabinoids, which can lead to chronic conditions such as irritable bowel syndrome or migraines. When taken as a supplement, phytocannabinoids, which come from plants, may be able to help ease some of the symptoms by helping our endocannabinoid system perform its delicate balancing act.*

One of the most talked-about and researched phytocannabinoids in hemp oil and CBD oil is, of course, CBD. But that’s just the tip of the iceberg: Scientists are still studying just how many cannabinoids can be derived from hemp and what their capabilities are individually, collectively, and in various combinations.

What’s more, cannabinoids are just some of the beneficial compounds present in cannabis that end up in a full-spectrum product. “We know that phytocannabinoids are more effective and better tolerated when taken together and in concert with their co-occurring terpenes, flavonoids, and other phytochemicals than when they are taken in isolation,” explains Jessica Knox, M.D., MPH, co-founder of the American Cannabinoid Clinics and a preventive medicine physician.

Terpenes, responsible for the aroma of cannabis, enhance how we process the plant’s many cannabinoids. And flavonoids—also abundant in tea, fruits, veggies, and more—are phytonutrients known to have anti-inflammatory and anti-oxidative effects.

“When you mix all those phytocannabinoids together and not just the phytocannabinoids—but their supportive compounds and antioxidants that are in the [hemp plant] stalk—it’s a whole mix,” Rountree explains. “There’s this whole system at work.”

Whole Greens CBD Review June 2022

Whole Greens CBD is dedicated to providing CBD products accessible within the US and internationally.

The brand provides a range of affordable and all-natural and lab-tested CBD products, including oils, capsules, gummies, and pet treats.

Looking for something different? See our top CBD Oil for 2021

Company Analysis

The brand offers assistance programs, including discounts for low-income citizens, disabled customers, and veterans.

CBD Isolate Capsules 300mg

Recommended for Optimizing Wellness

Whole Greens CBD uses select ingredients to utilize the benefits of naturally-occurring CBD. All products have undetectable THC levels, making them non-psychoactive.

Source of Hemp

Whole Greens CBD sources its hemp from Colorado, USA.

Popular Products

There are 24 products listed on the Whole Greens CBD shop. Their most popular products include 30ml bottles of Peppermint Full-Spectrum CBD Oil (1,000mg), CBD Isolate Capsules (300mg), and CBD-infused gummies (200mg).

Types Sold

Whole Greens CBD oil products contain full-spectrum CBD. Its CBD capsules contain CBD isolate.

Range of Products/Forms

Whole Greens CBD offers a variety of CBD products. These include oils, topicals, capsules, gummies, and pet treats.

Extraction Method/s

Whole Greens CBD uses a cold CO 2 extraction method.

Lab Testing Transparency/Availability

Lab results for Whole Greens CBD products are available on the brand’s website by product type.

CBD Concentration per Serving Range

The COA and product label indicate that a 30ml bottle of Whole Greens CBD oil may contain 250mg to 5,000mg of CBD.


The certificate of analysis indicates that a 30ml bottle of Whole Greens CBD oil may contain 8.87mg/ml to 80.9mg/ml of CBD.

THC Range of Products % (

Based on the COA of several Whole Greens CBD products, the THC content is undetectable.


Whole Greens CBD products come in peppermint and mint chocolate flavors.

Tincture Carrier Oil

Whole Greens CBD lists hempseed oil among the ingredients of their products.

Lab Results

Lab test results for every range of Whole Greens CBD products are available on the brand’s website.

Price Range

The cheapest product listed on the Whole Greens CBD is $19.95 for a 30ml bottle of CBD oil for pets.

The most expensive product is $320 for a product bundle, which includes CBD oil (5,000mg – mint chocolate), CBD capsules (750mg), topical relief cream (750mg), and CBD-infused gummies (600mg).

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Whole Greens CBD offers several shipping methods. Orders for free shipping arrive within 5-10 business days, first-class mail arrives within 3-6 business days, and priority orders arrive within 2-3 business days.

Next day shipping is available in most locations. International orders depend on distance, foreign customs and regulations, and local laws.


Whole Greens CBD products carry a 30-day money-back guarantee for customer satisfaction.

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Customers can return an item to Whole Greens CBD upon request within 30 days of purchase.


Whole Greens CBD products are certified free of GMOs, synthetics, pesticides, herbicides, and other contaminants.

Vegan and Gluten-Free

Whole Greens CBD products are certified free of GMOs, synthetics, pesticides, herbicides, and other contaminants.

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Cons of Whole Greens CBD

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Review of Whole Greens CBD Full Spectrum CBD Oil

Whole Greens CBD Full-Spectrum Oil is a traditional CBD oil product that anyone can incorporate into their daily life. Users can add this CBD oil to food and beverages or take it sublingually.

A 30ml bottle comes in either peppermint or mint chocolate flavors. There are five available strengths: 250mg, 500mg, 1,000mg, 3,000mg, and 5,000mg. CBD contains essential pain-relieving properties [1] of the cannabidiol compound found in hemp plants [2] .

The full-spectrum type of product means users benefit from CBD oil and dozens of other naturally-occurring cannabinoids. Users take advantage of the “entourage effect,” which studies suggest can treat major depression and mood disorders [3] .

Review of Whole Greens CBD Isolate Capsules 300mg

Another popular Whole Greens CBD product is the CBD Isolate Capsules. It comes in bottles good for 30 servings and contains 300mg of CBD.

This method is convenient for customers to utilize CBD’s anxiety-relieving properties [4] directly. It is a straight-forward product that needs no measurement or mixing. Consistent usage may yield optimal results.

Still, consulting with a physician before adding CBD into one’s diet is best to ensure safety.

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Cbd oil for prozac withdrawal

Pharmacological Treatment of Cannabis Dependence

* Address correspondence to this author at the Department of Medical Biophysics and Nuclear Medicine, Hadassah Medical Organization, Ein Kerem, Jerusalem 91120, Israel; Tel: 972(2)6776705; Fax: 972(2)6421203; [email protected]


Cannabis is the most frequently used illegal psychoactive substance in the world. There is a significant increase in the number of treatment admissions for cannabis use disorders in the past few years, and the majority of cannabis-dependent individuals who enter treatment have difficulty in achieving and maintaining abstinence. Thus, there is increased need for medications that can be used to treat this population. So far, no medication has been shown broadly and consistently effective; none has been approved by any national regulatory authority. Medications studied have included those that alleviate symptoms of cannabis withdrawal (e.g., dysphoric mood, irritability), those that directly affect endogenous cannabinoid receptor function, and those that have shown efficacy in treatment of other drugs of abuse or psychiatric conditions. Buspirone is the only medication to date that has shown efficacy for cannabis dependence in a controlled clinical trial. Results from controlled human laboratory studies and small open-label clinical trials suggest that dronabinol, the COMT inhibitor entacapone, and lithium may warrant further study. Recent pre-clinical studies suggest the potential of fatty acid amide hydrolase (FAAH) inhibitors such as URB597, endocannabinoid-metabolizing enzymes, and nicotinic alpha7 receptor antagonists such as methyllycaconitine (MLA). Controlled clinical trials are needed to evaluate the clinical efficacy of these medications and to validate the laboratory models being used to study candidate medications.


Cannabis is the most frequently used illegal substance in the world [1–3]. Cannabis abuse and cannabis dependence are diagnoses recognized in the United States Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) [4] and the WHO International Classification of Diseases, Tenth Revision (ICD-10) [5]. In the United States, the number of individuals with disorders associated with cannabis use is twice that of any other illicit drug [1], with approximately 4 million adults meeting criteria for a life-time diagnosis of cannabis dependence [6]. Relapse rates for cannabis users in treatment are comparable to those found for other drugs of abuse [7–11].


Exogenous cannabis (and its primary psychoactive component, Δ-9-tetrahydrocannabinol [THC]) acts on the endogenous cannabinoid (endocannabinoid) system in the brain and other body tissues by binding to two different types of cannabinoid receptors on cell membranes: CB1 and CB2 [12]. CB1 receptors are located primarily in pre-synaptic neurons of the CNS and are responsible for the acute psychological and cardiovascular effects of cannabis. CB2 receptors are located largely in the periphery and modulate immune function and inflammatory response.

Endocannabinoids (endogenous ligands at CB receptors) such as anandamide serve as retrograde neuromodulators of synaptic activity. They are released postsynaptically by a variety of stimuli upon demand, travel across the synaptic cleft, and then activate presynaptic CB receptors. A membrane transporter actively takes anandamide into the cell. Anandamide is then broken down by fatty acid amide hydrolase (FAAH) [13–15].

The neuropharmacological mechanism of cannabis dependence may involve interactions of the endocannabinoid system with the dopaminergic and opioid systems. Additionally, CB receptor agonists such as THC act as inhibitors of neurotransmission in acetylcholine, GABA, and glutamatergic pathways. Chronic administration of cannabinoids leads to down-regulation of the CB receptor and receptor function desensitization [16].

THC like other drugs of abuse, releases DA in the mesocortico-limbic regions of animal brains [17–19]. PET brain imaging studies in healthy human volunteers provide inconsistent evidence for this action in humans. One study showed modest THC-induced dopamine release in the ventral striatum and dorsal putamen using [ 11 C] raclopride [20]. Another study found no significant effect of THC on [ 11 C] raclopride binding, although THC markedly increased psychosis-like symptoms [21]. A subsequent study using the same methodology found significant decreases in frontal and temporal lobe [ 11 C] raclopride binding after THC challenges, but no changes in the striatum, which is also part of the dopamine reward pathway [22]. Decreased frontal lobe binding significantly correlated with catechol-O-methyltransferase (COMT) status. Therefore, medications that target the brain dopamine reward system may have a role in the treatment of cannabis dependence, as they may for other drugs of abuse.


Cannabis intoxication is a syndrome recognized in DSM-IV [4] and ICD-10 [5], with both psychological and behavioral (euphoria, relaxation, increased appetite, impaired memory and concentration), and physical (motor incoordination, tachycardia, orthostatic hypotension), manifestations. Intoxication is usually mild and self-limiting, not requiring pharmacological treatment [23]. The most severe effects (anxiety, panic, psychosis) are best treated symptomatically with a benzodiazepine or second-generation (atypical) anti-psychotic medication. No medication is approved specifically for treatment of cannabis intoxication.

Studies with the selective CB1 receptor antagonist/inverse agonist rimonabant suggest that CB1 receptors mediate many of the acute effects of cannabis in humans. In a double-blind, placebo-controlled study of 63 healthy men with a history of cannabis use, single oral doses of rimonabant produced significant dose-dependent blockade of the subjective intoxication and tachycardia caused by smoking an active (2.64% THC) or placebo (double-blind) cannabis cigarette 2 hours later [24] The 90-mg dose produced about 40% reductions in ratings of “high” “stoned” and “drug effect” (on 100-mm visual-analogue scales) and a 60% reduction in heart rate. Rimonabant alone produced no significant physiological or psychological effects and did not affect peak THC plasma concentration or its time course. This pattern of findings suggests that the observed attenuation of cannabis effects was specifically due to CB1 receptor blockade, and not to reduction in brain THC concentration or counteracting effects of rimonabant.

CB receptor antagonists such as rimonabant might be useful in treating acute cannabis intoxication, in the way that the mu-opioid receptor (mOR) antagonists naloxone and naltrexone are used to treat opiate intoxication. However, such medications are no longer available for clinical use. Rimonant and similar CB1 receptor antagonists were withdrawn from clinical development and use because of psychiatric side-effects associated with their long-term use [25].


Both human laboratory and clinical outpatient studies have established the reliability, validity and time course of the cannabis withdrawal syndrome [26, 27] and the cannabis withdrawal syndrome has been proposed for inclusion in DSM-V [28]. Some US studies suggest that about half of patients in treatment have reported symptoms of the cannabis withdrawal syndrome [23, 29–33]. The main symptoms of cannabis withdrawal are anxiety, irritability, depressed mood, restlessness, disturbed sleep, G-I symptoms, and decreased appetite. Most symptoms begin during the first week of abstinence and resolve after a few weeks.


Because symptoms of cannabis withdrawal may serve as negative reinforcement for relapse to cannabis use in individuals trying to abstain [27, 34], pharmacological treatment aimed at alleviating cannabis withdrawal might prevent relapse and reduce dependence.

Several studies have tested the effects of medications on cannabis withdrawal [35–37]. These medications are either CB receptor agonists that directly suppress the withdrawal syndrome (analogous to using an opiate to suppress heroin withdrawal) or are designed to indirectly alleviate symptoms of cannabis withdrawal (e.g. dysphoric mood, irritability) by influencing the brain circuits that mediate these symptoms. No medication has regulatory approval for the treatment of cannabis withdrawal. The CB receptor agonist THC has shown efficacy in several human laboratory studies and open-label case series. See Table 1 for description of all pharmacological treatment trials for cannabis dependence.

Table 1

Pharmacological Trials for Cannabis Dependence

1. Anti-Depressants
Study Drug N Dose Design Results
Haney et al., (2001) Bupropion (10) 300mg Randomized Double-blind Placebo-controlled Cross-over Worsened withdrawal
Haney et al., (2003a) Nefazodone (7) 450mg Randomized Double-blind Placebo-controlled Cross-over Improved anxiety
* Cornelius et al., (2005) Fluoxetine (22) 20–40mg Randomized Double-blind Placebo-controlled Cross-over Reduced cannabis use
Haney et al., (2008) Lofexidine+ THC (8) 2.4mg 60mg Placebo-controlled Reduced withdrawal
* Carpenter et al., (2009) Nefazodone Bupropion (106) 300mg 150mg Randomized Double-blind Placebo-controlled Cross-over No effect
Haney et al., (2010) Baclofen Or Mirtazapine (11) 30, 60, 90 mg 30mg Randomized Double-blind Placebo-controlled Cross-over No effect
* Cornelius et al., (2010) Fluoxetine (70) 20 mg Randomized Double-blind Placebo-controlled Cross-over No effect
2. Cannabis Agents

Most published studies have been human laboratory studies of short duration (typically 3–4 days), using an inpatient human laboratory model developed at Columbia University (New York, US) [35]. Participants were non-treatment-seeking volunteers who smoked cannabis many times a day. They smoked cannabis (active or placebo) and received oral medication (active or placebo) each day under double-blind conditions. The protocols used a within-subjects crossover design so that each participant received each active and placebo combination of cannabis and medication [38].

The early laboratory studies evaluated divalproex, an anticonvulsant which is used clinically as a mood stabilizer and to treat epilepsy and migraine headaches [39] buproprion, which is used clinically as an antidepressant and for smoking cessation; and nefazodone, an antidepressant that blocks post-synaptic 5HT-2a receptors and inhibits pre-synaptic 5HT and NE reuptake [40]. Bupropion is thought to exert its clinical effects by inhibiting reuptake of norepinephrine (NE) and dopamine (DA) and possibly by acting as a nicotine receptor antagonist [41]. Single doses of bupropion sustained-release (300 mg/day for 17 days) and divalproex (1500 mg/day for 29 days) actually worsened, rather than improved, some withdrawal symptoms and had no positive effects [42, 43]. A single dose of nefazodone (450 mg/day) decreased some, but not the majority, of cannabis withdrawal symptoms [44].

So far, the only medication successful in suppression of withdrawal symptoms in the laboratory was a single dose of 10mg/day oral synthetic THC (dronabinol) [44]. Oral THC was also more effective than placebo in an outpatient study in which oral THC was given to 8 adult, daily cannabis users who were not seeking treatment in a 40-day, within-subject design study [44]. Participants received daily doses of placebo, 30 mg (10 mg/tid), or 90 mg (30 mg/tid) oral THC during three 5-day periods of abstinence from cannabis use, separated by 7–9-day periods of cannabis smoking as usual. Comparison of measures of withdrawal symptoms across conditions indicated a dose-dependent reduction of withdrawal discomfort by THC. Minimal adverse effects were associated with either THC dose. This demonstration of dose-response effect replicates and extends prior findings of the pharmacological specificity of the cannabis withdrawal syndrome [43].

More recently, the Columbia group has evaluated medications in a more complicated human laboratory design that models both withdrawal and relapse. Regular cannabis users were maintained on each medication condition for 7 inpatient days. Each medication phase was separated by an outpatient washout phase. During the first three inpatient days, placebo cannabis was available for self-administration (withdrawal). For the next 4 days, active cannabis was available for self-administration. Participants paid for self-administered cannabis using study earnings.

The first such study evaluated lofexidine, an agonist at the alpha2-adrenergic receptor that is used to treat opiate withdrawal [46]. Lofexidine was tested both alone and in combination with THC [47]. Eight non-treatment-seeking male regular cannabis users were maintained on each of four medication conditions double-blind: placebo, THC (60 mg/day), lofexidine (2.4 mg/day), and THC (60 mg/day) combined with lofexidine (2.4 mg/day). THC reversed the anorexia and weight loss associated with cannabis withdrawal, and decreased some withdrawal symptoms, but increased sleep onset latency, and did not decrease the resumption of cannabis use when active cannabis was available. Lofexidine, which was sedating, worsened withdrawal-related anorexia and did not robustly attenuate mood symptoms associated with withdrawal, but improved sleep and decreased cannabis relapse. The combination of lofexidine and THC produced the most robust improvements in sleep and decreased cannabis withdrawal, craving, and relapse in daily cannabis smokers relative to either medication alone.

The second such study evaluated baclofen, a GABA B receptor agonist and antispasmodic medication that reduces mood symptoms in heroin withdrawal [48], and mirtazapine, an antidepressant that enhances noradrenergic and serotonergic transmission and decreases withdrawal symptoms in alcohol-dependent patients [49], especially agitation and insomnia [50]. In this study, separate groups received baclofen (60, 90 mg/day) for 16 days (n=10) or mirtazapine (30 mg/day) for 14 days (n=11) [51] Medication administration began when subjects were outpatients prior to each 8-day inpatient phase. On the first inpatient day of each medication condition, participants smoked active cannabis (baclofen group : 3.3% THC; mirtazapine: 6.2% THC). For the next 3 days, participants could self-administer placebo cannabis (withdrawal phase), followed by 4 days in which they could self-administer active cannabis (relapse phase). During active cannabis smoking, baclofen dose-dependently decreased craving for tobacco and cannabis, but had little effect on mood during abstinence and did not decrease relapse. Mirtazapine improved sleep during abstinence, and robustly increased food intake, but had no effect on withdrawal symptoms and did not decrease cannabis relapse. Overall, this human laboratory study did not find evidence to suggest that either baclofen or mirtazapine show promise for the treatment of cannabis withdrawal.


3.1. Agonist Approach

One strategy to treat drug dependence is long-term treatment with the same agonist drug or with a cross-tolerant drug to suppress withdrawal and drug craving. This approach is successfully used in the treatment of tobacco (nicotine) dependence (nicotine itself) and opiate dependence (methadone, buprenorphine). It is being studied for treatment of cannabis dependence using synthetic THC which is legally marketed in many countries as an oral medication for appetite stimulation and suppression of nausea and vomiting due to chemotherapy. Questions of medication abuse and diversion must be addressed, as with opiate agonist substitution treatment.

Use of oral synthetic THC in outpatients was reported in a study that showed the potential benefit, as well as questions that arise from the use of this medication in cannabis-abusing populations [52]. Controlled clinical trials of oral THC are currently underway (

3.2. Antagonist Approach

The antagonist approach uses long-term treatment with a CB1 antagonist to prevent patients from experiencing the pleasurable reinforcing effects of cannabis use, resulting in extinction of drug-seeking and drug-taking behavior. This approach has been used successfully with the mOR antagonist naltrexone in the treatment of opiate dependence [53]. It could be implemented should a CB1 receptor antagonist again become available for human use.

A recent randomized, double blind, parallel group study investigated whether subacute (2-week) treatment with the CB1 receptor antagonist rimonabant (40 mg daily) attenuated the effects of smoked cannabis in 42 healthy men with a history of cannabis use [54]. The repeated daily rimonabant doses attenuated the acute cardiovascular effects of a cannabis cigarette (2.78% THC) to a similar degree as a single 90-mg dose; repeated 40-mg doses attenuated subjective effects after 8 but not 15 days (possibly because of smaller sample size and lower statistical power at day 15). Rimonabant did not significantly affect THC pharmacokinetics, suggesting that the observed effects were due to receptor blockade and not reduced THC levels in the brain.

3.3. Other Approaches

Alternative pharmacotherapy approaches may arise from improved understanding of the neuropharmacology of cannabis use disorders, including the recognition that (i) frequent cannabis use may cause an adaptive down-regulation of brain endocannabinoid signaling, and (ii) genetic traits that favor hyperactivity of the endocannabinoid system in humans may decrease susceptibility to cannabis dependence [55]. These findings suggest that pharmacological agents that elevate brain levels of the endocannabinoid neurotransmitters anandamide and 2-arachidonoylglycerol (2-AG) might alleviate cannabis withdrawal and dependence. One such agent, the FAAH inhibitor URB597, selectively increased anandamide levels in the brain of rodents and primates. Preclinical studies showed that URB597 produced analgesic, anxiolytic-like, and antidepressant-like effects in rodents, which were not accompanied by overt signs of abuse liability. This evidence suggests that FAAH inhibitors such as URB597 might offer a possible therapeutic avenue for the treatment of cannabis withdrawal [55].

3.3.a. Opiate Antagonist Naltrexone

Because animal studies show that mOR antagonists block effects of THC, several human laboratory studies have investigated whether the mOR antagonist naltrexone can reduce the subjective effects of cannabinoids in humans. In cannabis users, pretreatment with high doses of naltrexone (50–200 mg) failed to attenuate or enhanced the subjective effects of THC [56, 57] or smoked cannabis [58]. However, a lower, more mOR-selective dose of naltrexone (12 mg) decreased the intoxicating effects of 20 mg, but not 40 mg, of THC [59]. A recent placebo-controlled study in 29 heavy cannabis smokers found that opioid-receptor blockade by naltrexone (12, 25, 50, or 100 mg daily) enhanced the subjective and cardiovascular effects of cannabis [60]. This pattern of human experimental findings is not completely consistent, but suggests that clinically used doses of naltrexone would not be effective as treatment for cannabis dependence, and might actually increase the abuse liability of cannabis.

3.3.b. Dopamine Agents
Catechol-O-Methyl Transferase (COMT) Inhibitor– Entacapone

Dopamine (DA) is a major neurotransmitter in the brain’s meso-cortico-limbic reward pathway, believed to be a common pathway involved in drug-seeking for all drugs of abuse [61–63] DA deficiency in this reward pathway plays a major role in drug compulsion and craving [64]. Catechol-O-methyl transferase (COMT) is an enzyme that inactivates catecholamine neurotransmitters and plays a pivotal role in regulating homeostatic levels of DA neurotransmitter in the inter-synaptic cleft. COMT inhibitors would increase synaptic DA activity, perhaps counteracting the DA deficiency considered to play a role in drug compulsion and craving. The gene for COMT is located on chromosome 22q11.21 There is some evidence that carriers of the valine158 allele of the COMT gene, who should have increased brain dopamine turnover, are at increased risk for psychotic symptoms and development of schizophrenia if they use cannabis by the age of 18 [65]. However, these findings were not replicated in a later study [66].

As mentioned earlier, THC, like other drugs of abuse, releases DA in the meso-cortico-limbic regions of animal brains. PET brain imaging studies in healthy volunteers so far seems to suggest that THC administration results in modest dopamine release in some human brain regions, but the role of this action in the rewarding effects of THC remains unclear. Therefore, the place in treatment of medications that target the brain dopamine reward system also remains unclear.

Entacapone is a COMT inhibitor approved for the treatment of Parkinson’s disease, in a recent study entacapone (up to 2000 mg/day) was given to 36 patients with cannabis dependence (DSM-IV) in an open-label trial for 12 weeks, continued for 12 months in interested individuals. Entacapone both short-term and long-term significantly decreased craving for cannabis in 52.7% of the patients, but no information was reported on patients’ cannabis use. Entacapone was well tolerated and there was no serious adverse event [67].

3.3.c. Glutamate- N-acetylcysteine (NAC)

The neurotransmitter glutamate has emerged as a potential target in the treatment of addictions, such as cocaine, nicotine, and cannabis dependence. In animal studies, N-acetylcysteine (NAC) reverses drug-induced down-regulation of the cystine-glutamate exchanger, which restores normal regulation of glutamate release, reducing compulsive drug-seeking behaviors [68]. Consistent with this evidence, preliminary studies have demonstrated significant reductions in cocaine craving [69] and cigarette use [70] during NAC treatment.

A recent open-label study gave NAC (1,200 mg) twice daily for 4 weeks to 24 cannabis-dependent males and females who were interested in reducing their cannabis use [71]. Treatment with NAC was well tolerated and associated with significant decreases in self-report measures of cannabis use and craving, but no change in semi-quantitative urine cannabinoid levels.

3.3.d. Norepinephrine Reuptake Inhibitor- Atomoxetine

Cannabis users demonstrate time and dose-dependent impairments in attention, memory, executive function and response inhibition that resemble deficits in patients with attention deficit hyperactivity disorder (ADHD) and share morbidity with this disorder [72]. A recent study [73] evaluated atomoxetine, an ADHD medication with low abuse potential, in an 11-week open-label study of thirteen treatment-seeking, cannabis-dependent patients (25, 40, 80mg/day). For the eight participants who completed the study, there was a trend towards reduction in cannabis use and increase in percent days of abstinence. The majority of patients experienced gastrointestinal adverse events.

A more recent double-blind, placebo-controlled 12-week study of atomoxetine (25–100 mg/day escalating doses) in 38 cannabis-dependent outpatients with concurrent ADHD found no significant change in cannabis use, although there was some improvement in ADHD symptoms [74].

3.3.e. Anxiolytic- Buspirone

Buspirone shares some of the properties of the benzodiazepines and the neuroleptics; it is a 5-HT (1A) receptor agonist [75] and a D2 receptor antagonist [76]. A preliminary 12-week, open-label study in 10 cannabis-dependent men found that buspirone (maximum 60 mg per day) in a 12-week open-label trial significantly reduced frequency and duration of cannabis craving and use and reduced irritability and depression [77]. A following 12-week controlled clinical trial compared buspirone (maximum 60mg/day) vs. placebo, together with motivational interviewing, in 23 cannabis-dependent participants [78]. Among the 24 participants who completed the trial, those randomized to buspirone had a greater percentage of cannabis-negative urine samples (95% CI:7–63%, p<0.05) and a trend towards achieving the first cannabis-negative urine sample sooner than those participants treated with placebo. These findings support the promise of buspirone as a treatment for cannabis dependence.

3.3.f. Mood Stabilizers

Lithium is a mood stabilizer used primarily in the treatment of bipolar disorder (depression and mania), both acutely and chronically. A preclinical study showing that lithium attenuated cannabis withdrawal in rats [79] prompted two small open-label clinical studies. In the first study, lithium (600 to 900 mg/day), administered to 9 adults for 6 days, reduced withdrawal symptoms in 4 of the 9 participants [80]. However, cannabis was admittedly smoked during this period by one of these 4 participants and cannabis abstinence was not verified in the others. In the second study, 20 cannabis-dependent participants received lithium (500 mg 2x/day) for 7 days in an inpatient detoxification facility [81]. Twelve participants completed the 7-day inpatient detoxification. Self-reported cannabis abstinence at post-treatment follow-up sessions was 64% (Day 10), 65% (Day 24), and 41% (Day 90). Participants self-reported cannabis abstinence on 88% of days post-treatment. Five participants reported continuous abstinence that was corroborated with urine toxicology tests on Day 90. These results provide limited support for a double-blind trial of lithium as treatment for cannabis dependence.

A small 6-week controlled clinical trial in 25 cannabis-dependent outpatients also receiving weekly relapse prevention psychotherapy found that divalproex (1500–2000 mg daily, to achieve plasma concentrations of 50–120 ng/mL) did not reduce cannabis use more than placebo and was poorly tolerated by participants [82].

3.3.g. Anti-Depressants

A 13-week controlled clinical trial comparing nefazodone (300mg/day), bupropion-sustained release (150mg/day), or placebo, plus weekly, individual coping skills therapy in 106 cannabis-dependent outpatients found no significant medication effects on cannabis use or cannabis withdrawal symptoms [83]. These results suggest that nefazodone and bupropion-sustained release are not effective in treating cannabis dependence.


Cannabis users frequently have co-morbid mood symptoms, especially depression [84, 85]. The prevalence of depression in this population suggested that anti-depressant medication might promote abstinence in this population.

Two studies evaluated the selective serotonin reuptake inhibitor (SSRI) anti-depressant medication fluoxetine in this population. A post hoc analysis of 13 cannabis-using patients among a larger sample of alcohol-abusing, depressed adolescents treated with fluoxetine (20–40 mg daily) showed reduction in cannabis and alcohol dependence and depressive symptoms [86]. Five-year follow-up of 10 patients showed that cannabis and alcohol dependence were reduced and academic ability improved, but clinical depression remained problematic. A later 12-week, controlled clinical trial in 70 adolescents and young adults with comorbid major depression and cannabis use disorder found fluoxetine (20 mg daily) no better than placebo in treating either the depressive symptoms or the cannabis- related symptoms [87]. The lack of a significant between-group difference in symptoms may reflect limited medication efficacy, a ceiling effect because of the efficacy of the concurrent psychosocial treatment (cognitive behavioral/motivational enhancement psychotherapy), or low statistical power from small sample size.


Several recent studies in animals have used compounds that affect the endocannabinoid system and offer promising leads for future therapeutic agents. First, the benzoflavone moiety from methanol extracts of passiflora incarnate Linneaus reversed the effects of THC in mice [88]. Second, nicotinic alpha7 receptor antagonists such as methyllycaconitine (MLA) antagonized the discriminative effects of cannabinoids at doses that did not produce depressant or toxic effects [89]. Finally, inhibitors of endocannabinoid- metabolizing enzymes reduced rimonabant-induced precipitated withdrawal responses in THC- dependent mice [90]. These results suggest several potential therapeutic agents that warrant further study.


Results from controlled human laboratory studies suggest that CB1 receptor antagonists, should they again become available for clinical use, might be effective treatment for cannabis intoxication and that oral THC (perhaps combined with an α-adrenergic agonist such as lofexidine) might be effective treatment for cannabis withdrawal. For the treatment of cannabis dependence, there is little data to guide the clinician, as few controlled clinical trials have been conducted. Only buspirone has shown efficacy in such a trial, while atomoxetine, bupropion, divalproex, and nefazadone have not. A few small open-label clinical trials suggest that the COMT inhibitor entacapone, dronabinol, and lithium may warrant further study, although this recommendation is tempered by the weakness of evidence from open-label studies. In contrast, available evidence from human laboratory studies suggests that the mu-opioid receptor antagonist naltrexone may increase the abuse liability of cannabis and therefore should not be used for treatment. Recent pre-clinical studies suggest the potential of FAAH inhibitors such as URB597 for the treatment of cannabis withdrawal and of endocannabinoid-metabolizing enzymes andnicotinic alpha7 receptor antagonists such as methyllycaconitine (MLA) for treatment of cannabis dependence.

In response to the continuing public health problem that they pose, the National Institute on Drug Abuse launched in 2004 a research program to develop medications for treating cannabis use disorders (CUDs) [16] which hopefully will bear fruit in the future.


Dr. Weinstein is supported by the National Institute for Psychobiology in Israel that is funded by the Charles E. Smith Foundation. Dr. Gorelick is supported by the US National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health.


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Does CBD Interact With Fluoxetine (Prozac)?

Fluoxetine (Prozac), is a common prescription SSRI medication used in the treatment of anxiety and depression.

There’s a moderate risk of CBD interacting with fluoxetine.

Article By

According to the CDC, roughly 13% of the population takes antidepressant medications. Another survey found that nearly 14% of the population takes CBD .

Unsurprisingly, there are a lot of people who take both CBD (cannabidiol) and SSRIs at the same time.

Is this combination safe? Are there any dangers to be aware of? We’ll explore the potential risks and interactions when combining CBD with fluoxetine (Prozac).

Table of Contents
  • Does CBD Interact With Fluoxetine (Prozac)?
  • Precautions While Taking Fluoxetine

Does CBD Interact With Fluoxetine (Prozac)?

There is a moderate risk of increased side effects when using CBD with antidepressants such as fluoxetine (Prozac) [1].

The chances of users experiencing a serious interaction are low. However, some of the rare but possible side effects are severe — including seizures and serotonin syndrome.

There are two main ways CBD can interact with fluoxetine.

Interaction 1: Slowed Elimination (Metabolic Inhibition)

CBD strongly interacts with other drugs metabolized by CYP2C19 and moderately interacts with drugs metabolized by CYP2D6 [2].

Most SSRIs, including fluoxetine, are also metabolized by CYP2D6 [3]. Fluoxetine is a moderate inhibitor of drugs metabolized by CYP2D6 but a strong inhibitor of drugs metabolized by CYP2C19.

Since CBD and fluoxetine compete for metabolism in the liver, serum levels of both compounds can elevate. This slows fluoxetine’s metabolization, which, in turn, increases the possibility of side effects.

Adverse effects from mixing CBD with fluoxetine include nausea, diarrhea, and headaches.

Interaction 2: Increased Effect (Agonistic Interaction)

Simultaneously taking two substances with similar actions results in an agonistic interaction. CBD and fluoxetine may compound each other’s actions as they are both used to treat depression, anxiety, and panic disorders.

This interaction can result in serious side effects.

Therefore, before taking CBD and fluoxetine together, you must consult with your physician first. They may want to reduce your dose of Prozac or advise you to separate your dose of SSRIs and CBD by about 2-hours to minimize your risk.

Other Names for Fluoxetine

Fluoxetine is a generic drug marketed under many different brand names. All of the following medicines share the same risk and potential for interaction with CBD.

Some of the other names for fluoxetine are:

  • Prozac
  • Sarafem
  • Rapiflux
  • Selfemra
  • Fludac
  • Fludep
  • Flugen
  • Fluoxee
  • Flutrac

Similar Medications

Fluoxetine (Prozac) is classified as an SSRI drug. CBD and SSRIs interact and share the same risks.

  • Fluvoxamine (Luvox, Faverin, Fluvoxin, Boxamine, Fluvator)
  • Paroxetine (Aropax, Paxil, Pexeva, Seroxat, Sereupin, Brisdelle)
  • Sertraline (Zoloft, Lustral, Actiser, Dazolin, Depsert, Insert, Mares)
  • Citalopram (Celexa, Cipramil, C-pram, Celepra, Celica, Cipam, Citalent, Citalomine)
  • Escitalopram (Lexapro, Alwel, Anipram, Rhopram S, Talo, Szetalo, Stalopam, S Celepra)
  • Dapoxetine (Priligy, Dasutra, Duralast, Kutub, Dapox, Ejalong, Prilyxet, Xydap)

Is It Safe to Take CBD & Fluoxetine (Prozac) Together?

Safety concerns with the co-administration of CBD and fluoxetine (Prozac) are still a topic of debate. Few studies exist on potential drug interactions between these two substances.

CBD and fluoxetine, when taken together, may lead to some undesirable side effects such as dizziness, drowsiness, difficulty in concentrating, and confusion. Older individuals may experience impairment in motor coordination along with judgment and thinking.

A lower dosage of fluoxetine, when taken with CBD, may have fewer side effects than higher dosages. However, it’s best to avoid the co-administration of CBD and fluoxetine.

Consult your doctor before you combine CBD with any other medication, including fluoxetine.

Is CBD a Viable Alternative to Fluoxetine (Prozac)?

CBD could be a natural alternative in treating depression, substituting fluoxetine due to its similar effects, but it depends on what fluoxetine is prescribed for [4]. If it’s for anything other than mild depression, CBD is unlikely to help. It appears to be better tolerated than routine psychiatric medications [5].

According to the WHO, there have been no reports of a lethal overdose with CBD, and it has an exceedingly low potential for abuse or dependency [6].

CBD has a low overall risk of side effects with short-term use compared to most antipsychotics. However, further research is needed to evaluate possible long-term dangers and damages.

However, do not stop taking fluoxetine or adjust the dose as it can lead to withdrawal symptoms. Always consult your physician first before switching between drugs or supplementing prescribed antidepressants with CBD.

What Is Fluoxetine (Prozac)?

Fluoxetine (Prozac) is a prescription-only medication belonging to the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. It is a generic drug with trade names such as Prozac, Rapiflux, Sarafem, Barazac, and Selfemra.

It’s the drug of choice in treating obsessive-compulsive disorders, panic disorders, social phobias, eating disorders, premenstrual dysphoric disorder, and post-traumatic stress disorder.

These drugs also treat anxiety and bipolar disorders, body dysmorphic disorder, compulsive buying, kleptomania, and premature ejaculation.

It’s for use in children seven years or older only and is available in dosages of 10 mg, 20 mg, 40 mg, and 90 mg capsules.

Fluoxetine Specs

Drug name Fluoxetine
Trade Names Prozac, Rapiflux, Sarafem, Barazac, Selfemra, etc
Classification Selective Serotonin Reuptake Inhibitor (SSRI)
CYP Metabolism Metabolized by CYP2C19 and CYP2D6
Interaction with CBD Metabolic Inhibitor and Agonistic Interaction
Risk of interaction Moderate

What Does Fluoxetine Do?

Fluoxetine (Prozac), belonging to the SSRI class of drugs, blocks serotonin’s reabsorption (reuptake) into neurons.

This leads to increased levels of serotonin in the brain. SSRIs mainly affect serotonin, not other neurotransmitters. Serotonin, famously known as the happy hormone, stabilizes our mood, feelings of well-being, and happiness.

Side Effects of Fluoxetine

  • Rash
  • Sweating
  • Altered appetite and weight
  • Insomnia
  • Nervousness
  • Anxiety
  • Abnormal dreams
  • Weakness
  • Flu-like syndrome
  • Nausea
  • Diarrhea

The following are serious side effects that need immediate medical attention. Call your healthcare provider right away if you have any of these symptoms.

  • Allergic reactions and rash
  • Seizures
  • Abnormal bleeding
  • Potential for cognitive and motor impairment
  • Suicidal thoughts and behaviors in children, adolescents, and young adults under twenty-five years of age
  • Serotonin syndrome (change in mental status, overactive reflexes, fever)

Precautions While Taking Fluoxetine

Besides side effects, there are other things to be aware of if you’re using fluoxetine.

Concomitant Use With Alcohol

Do not mix CBD or fluoxetine with alcohol. The adverse effects of both substances may be fatal when taken with alcohol.

Use With Other Medication

Do not use fluoxetine if you have previously used monoamine oxidases (MAO) inhibitors such as phenelzine and tranylcypromine. It may lead to a condition known as serotonin syndrome, which is life-threatening.

Other drugs that increase serotonin levels include tricyclic antidepressants (TCA), triptans, amphetamine, methamphetamine, MDMA, buspirone, and serotonin-norepinephrine reuptake inhibitors.

Patients using blood-thinning medications should also avoid fluoxetine.


Opioids like pethidine, tramadol, dextromethorphan, and tapentadol will increase serotonergic activity. Fentanyl and methadone have similar effects but to a lesser degree.

A combination of opioids and fluoxetine may increase the risk of serotonin toxicity. Fluoxetine also blocks the metabolism of opioids leading to reduced analgesic effects [7].

Use In Pregnancy

Fluoxetine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus (Pregnancy Category C). It is not for use in breastfeeding women as fluoxetine is excreted in breast milk.

Dose Adjustments

Dose adjustments are required in patients with liver cirrhosis; these patients need lower or less frequent dosing. Unlike other drugs, dose adjustment for fluoxetine is not necessary for patients with impaired renal functions.


Do not stop fluoxetine without talking to your healthcare provider. Stopping the drug suddenly may cause serious withdrawal symptoms such as anxiety, irritability, high or low mood, feeling restless, or changes in sleep habits. Other symptoms include headache, sweating, nausea, dizziness, electric shock-like sensations, shaking, and confusion.

Key Takeaways: Is It Safe to Take Fluoxetine (Prozac) With CBD?

CBD is a natural, relatively nontoxic chemical with antidepressant action. There is a moderate risk if you use CBD and fluoxetine (Prozac) together.

Adverse effects of co-administration include dizziness, drowsiness, difficulty in concentrating, and confusion.

Always consult with your healthcare provider to ensure that CBD does not interact with any medication you are currently taking.

How I Used CBD and Research to Get off SSRI’s and avoid Serotonin Withdrawal Syndrome

We already covered the first great “weaning” I had to do with benzos (Xanax, Ativan, Valium) at our CBD for benzo withdrawal article.

Next, in lockstep, the doctors decided SSRI’s would be the best course of treatment for my rolling anxiety.

It nearly killed me.

More accurately, I suddenly didn’t want to live any longer.

It seems to be the go-to remedy for women entering a rough perimenopause as I did.

According to the doctor, it takes a few weeks to start working (not true. see CBD and SSRI’s to learn how they initially increase anxiety/depression).

About two weeks in, I was a mess.

Total flatline response.

No appetite. lost 10 pounds in 1 week. My stomach was a wreck.

Then I started to feel nothing.

No taste. No feeling. Just flat affect. (the technical term).

Negative thoughts crept up and even suicidal thoughts.

I ended up in the ER after I couldn’t sleep for 3 days straight.

The ER doctor there prescribed an anti-nausea drug (did I mention my gut was wrecked??) which has a strong warning against taking with SSRI’s.

Psychotic break, please.

As I mentioned in my story here, this was the lowest point of my life and I really was negotiating with “someone” as to whether I wanted to stay on this Earth any longer.

I had to stop the SSRI’s.

Apparently, I’m in good company if you check out the stats at the CBD versus SSRI’s page or CBD versus anxiety medications here.

They generally work for about 30% of patients until the body builds tolerance.

We’re going to really look at how CBD affects the same serotonin pathways but without tolerance below!

More importantly, we’ll address the real star of the show..BDNF! Our brain’s fertilizer!

Coming off of the benzos was brutal but this would turn out to be worse.

SSRIs don’t have the clinical addiction connection with dopamine but that doesn’t mean they’re easier to come off of.

You shouldn’t drop them cold turkey.

The focus of this article is how CBD might help with the process.

Research is shedding light on the pathways shared by both but in very different ways.

We’ll look at the following topics:

  • A quick introduction to the pathways of SSRIs and how CBD affects them
  • Can CBD help with SSRI withdrawal
  • Can CBD be taken with SSRI’s
  • Can CBD replace SSRI’s
  • My process using CBD to replace SSRI
  • Best CBD for SSRI withdrawal and replacement

Lots to cover and as with all our articles, we’re going to lean heavily on NIH research.

Let’s get started.

First, a lay of the land.

A quick introduction to the pathways of SSRIs and how CBD affects them

It’s important to get some background on what SSRI’s do in the body.

Our focus here is on anxiety (since that’s our current run of investigation) but SSRIs are actually more relevant for depression.

Either way, they affect the same pathway.

Serotonin is a powerful workhorse neurotransmitter in the brain.

In fact, 70% of our serotonin is actually made in the gut (see CBD and gut biome here).

SSRI’s primary lever is to boost the amount of serotonin available to neurons.

It turns out that the real effect of serotonin on the pathways of anxiety and depression deal with neurogenesis.

That’s why it takes so long to work.

Neurogenesis is the process of rebuilding and replenishing neurons.

Learn all about it at our CBD and neurogenesis article.

In fact, you can’t deplete serotonin or its precursor (tryptophan) and cause healthy people to suddenly display anxiety and depression:

Tryptophan depletion studies in never-depressed individuals are variable, with no or little overall effect on lowering of mood

Read that back over again. It’s really important.

Where they see an effect is in healthy people with a family member that has depression or people with past depression issues.

There appear to be other systems that influence this.

In fact, the gut microbiome’s role is coming to light:

Influence of gut microbiota on behavior is becoming increasingly evident

As we stated above, serotonin’s real effect on anxiety and depression appears to be in its ability to rebuild or repair specific brain areas under duress.

Many things can cause damage to these brain areas in the anxiety circuit:

  • Chronic inflammation
  • Chronic stress
  • Infection at specific times of brain development
  • THC (yes, CBD’s cousin in cannabis)
  • Gut bacteria dysregulation and gut permeability
  • Immune system response to weakened gut barrier
  • Trauma/Infection

The last one is critically important.

Early trauma or infection (even in utero -especially third trimester) can downregulate serotonin later in life (along with many other key pathways like GABA).

We have a monster review on it here.

Regardless of the cause, brain loss can feed into the pathway for anxiety and depression.

A good synopsis of it is here:

Pathological anxiety and chronic stress are associated with structural degeneration and impaired functioning of the hippocampus and the prefrontal cortex (PFC), which may account for the increased risk of developing neuropsychiatric disorders, including depression and dementia,”

So back to SSRI and serotonin.

A study looked at sertraline, an SSRI commonly used (brand name is Zoloft).

Their results:

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

Why is this important for SSRI’s which boost serotonin?

Similarly, we discuss the possibility that adult hippocampal neurogenesis mediates antidepressant effects via the ventral (in rodents; anterior in humans) hippocampus’ influence on the HPA axis, and mechanisms by which antidepressants may reverse chronic stress-induced 5-HT and neurogenic changes.

To decipher a bit…

5-HT is our serotonin pathway.

Neurogenesis (building and repairing brain tissue) in the hippocampus appears to be very important for longer-term anxiety and depression.

So. that’s the primary lever by which SSRI’s might affect anxiety and depression (till they don’t due to tolerance).

Of course, serotonin levels alone can also have an effect.

IF you have reduced serotonin levels.

There’s no good way to test for this so it’s a guess by the doctor.

Usually, they infer. anxiety or depression = low serotonin.

Here’s the important take away:

Chronic treatment with fluoxetine and imipramine induced anxiolytic-like effects in the novelty suppressed feeding test in control mice but not in animals that were submitted to x-ray-irradiation of the SGZ (SGZ-x-irradiation), a procedure that blunts neurogenesis by killing cells undergoing proliferation.

We’ll translate because this is the smoking gun of our whole discussion.

Long term administration of an SSRI (fluoxetine is Prozac) reduced anxiety in mice.

However, when the area of the hippocampus where neurogenesis was essentially turned off (via radiation), the anti-anxiety effects went away!

What about CBD and this serotonin pathway?

Turns out that CBD directly affects and serotonin function but without the nasty side effects.

The eCB-induced modulation of stress-related behaviors appears to be mediated, at least in part, through the regulation of the serotoninergic system

eCB is short for the endocannabinoid system in which CBD operates in.

More importantly, CBD directly bolsters the endocannabinoid system which is involved across the entire anxiety circuit. not just serotonin.

A great study on CBD and public speaking for people with social anxiety reflected this change in stress response:

Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech

It even reduces the physiological responses (heart rate, blood pressure, skin conductance) to stress:

this result suggests that CBD also protects the patients from their subjective physiological abnormalities induced by the SPST

This is important because remember that chronic stress and inflammation is what can do damage to brain areas such as the hippocampus which leads to long term anxiety and depressive states.

The long term stress is chemically displayed by cortisol.

The very thing – the “plasticity” or ability to change – of the hippocampus is what also makes it vulnerable to stress hormones like cortisol:

Imaging studies of the human hippocampus have suggested a negative relationship between cortisol levels and hippocampal volume.

As for cortisol, our stress hormone:

The present results suggest that CBD interferes with cortisol secretion.

Finally, as we saw with the mice and radiated hippocampus above, what about CBD and neurogenesis?:

More recently, a study conducted with transgenic mice (GFAP-TK mice) showed that the anxiolytic effect of chronic CBD administration (14 days) in stressed mice depends on its proneurogenic action in the adult hippocampus by facilitating endocannabinoid-mediated signaling

Voila! (my mother’s French so I get the pass).

This statement just means that CBD’s “long term” effect on anxiety are due to the same neurogenesis in the hippocampus that SSRI’s affect.

We’ve covered all these topics in detail but felt it was important to at least look at the shared pathways.

The interesting factor is that CBD doesn’t just boost serotonin levels regardless of baseline.

It supports the endocannabinoid system which balances serotonin levels.

You see this all over the research such as:

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

We have to translate that. it’s too important.

Essentially, they injured mice and which depleted serotonin and increased pain sensitivity and anxiety.

CBD reverses these effects and primary through the serotonin pathway!

The key work is “modulate”. Not boost like SSRIs.

Let’s get to more specific questions that originally brought us here.

Can CBD help with SSRI withdrawal

So. they don’t officially call it SSRI withdrawal.

They don’t officially say it’s “addictive”.

Personally, I can tell you it’s was one of the hardest things to come off of. ever!

Even rougher than the benzos (see CBD and benzo withdrawal) and they have a black box warning on the package!

Since SSRI’s don’t directly juice the dopamine system in the usual suspect region of the nucleus accumbens, they’re not classed as technically “addictive” or habit-forming.

They also don’t create euphoria (pleasure) or have the technical term of “hedonic”.

For this reason, problems with coming off of SSRI’s are grouped under the term Serotonin Discontinuation Syndrome.

George Orwell would be proud (and probably medicated).

Here’s the deal. serotonin is a master neurotransmitter in the nervous system (and gut).

Yes, it governs gut function, sleep, and sex drive but it’s real tour de force is on mood.

Sometimes called the “feel good” neurotransmitter, it can loosely be associated with feeling. right, grounded, whole. “Good in our own skin”.

Yes, those sound like cheesy catchphrases from a 60’s Woodstock song but nevertheless, this speaks to how widespread serotonin’s effect in the brain.

Many neurotransmitters are one-trick ponies.

GABA slows things down. Glutamate speeds them up. Cortisol is a stress response.

Serotonin is a blanket of activity across the brain.

This is obvious from the crazy catch-all of side effects from SSRI’s found here:

It’s an impressive list of bodily functions gone awry.

I can personally attest to a few of them including suicidal thoughts and total flat affect.

Check out some of the research on SSRI’s and suicidal or homicidal thoughts:

With age stratification, there was a significant association between SSRIs and violent crime convictions for individuals aged 15 to 24 y

By the way, CBD does not show any of these effects which aren’t surprising given the role of the endocannabinoid system and neurotransmitters.

The keyword there is “modulates”. Not increases. Not reduces.

The endocannabinoid system is shown to balance the key system in the body:

  • Nervous system – neurotransmitters such as serotonin and GABA
  • Endocrine system – hormones such as cortisol and histamine
  • Immune system – such as inflammatory agents which can damage brain areas

So. given the many pies that serotonin has its finger in, what do you think will happen when you take it away!

Unlike the benzos, at least the doctor warned me in advance not to stop it cold turkey.

I was prescribed Lexapro for rolling panic attacks and 24-7 anxiety (from perimenopause hormone drop and serum sickness from oral typhoid vaccine. story here).

After everything we learned, a high dose of CBD (300 – 600 mg) in the beginning would have been ideal.

I would wean that down to 300 mg for the long term effect of neurogenesis (see how many mg of CBD for anxiety here) which research shows on a bell curve. peaking about 300 mg.

I personally, take 150 mg in the morning and 150 mg before bed.

Before, my anxiety would race at night and interfere with my sleep.

It’s best to hold the CBD oil under your tongue for up to 60 seconds (see how to increase CBD by 4xs here).

Ideally, you want to take it after a meal so more can get into the bloodstream.

It’s important to take CBD at least 4 hours away from any medication including SSRIs.

They both can use the same pathway in the liver (p450) for processing which might boost or reduce levels of the SSRI in the bloodstream.

Work with a naturopath.

Remember how we said that CBD “modulates” serotonin function.

Here’s the critical piece of that study:

Seven days of treatment with CBD reduced mechanical allodynia, decreased anxiety-like behavior, and normalized 5-HT activity.

Rather than just increase serotonin available in the brain and body, CBD worked through the endocannabinoid system to affect receptor sensitivity.

  • Too much serotonin is bad (See Serotonin syndrome below).
  • Too little serotonin (function) is bad (anxiety, depression, and a host of mood disorders).

The most important word in that statement is “normalize”.

Balance is our goal.

There’s interesting research on how CBD does this by influencing our brain’s own conversion of tryptophan to serotonin:

these cannabinoids in the modulation of serotonergic signaling by their capacity to increase the availability of circulating tryptophan, the precursor necessary for the biosynthesis of the neurotransmitter 5-hydroxytryptamine (5-HT; serotonin)

It’s fascinating and could be a key between inflammation/infection and mood disorders.

The closest direct study we have for withdrawal is brand new with opioid withdrawal.

It’s even more difficult than SSRI withdrawal since the dopamine and naturally occurring opioid systems in the brain are hit hard!

The results from a double-blind study:

Acute CBD administration, in contrast to placebo, significantly reduced both craving and anxiety induced by the presentation of salient drug cues compared with neutral cues.

Big review on CBD and opioid withdrawal here.

More interestingly to us is the long term effect it had:

CBD also showed significant protracted effects on these measures 7 days after the final short-term (3-day) CBD exposure.

We’re not sure why this isn’t on every broadcast across the country given the opioid (and soon to be benzo) epidemic.

SSRI’s are different in that it’s more a function of serotonin balancing but the opioid study is a powerful example.

Here’s an interesting point.

SSRI’s eventually build tolerance.

This is a technical term for the brain’s reaction to boosting serotonin by making less serotonin itself to offset the outside influence.

The brain will literally reduce the number and sensitivity of serotonin receptors.

That’s why doctors will change SSRI’s after a period of time or increase dosages.

Eventually, the SSRI will be ineffectual aside from long term neurogenesis effects we mentioned above.

Of course, if you still have the chronic stress, inflammation, or immune response, the damage to the hippocampus continues unabated.

Here’s the issue.

When you come off the SSRI. even slowly. you’ll definitely have a reduced baseline serotonin level even if you didn’t actually have one before.

A great book called Never Enough by Judith Gisel explains this reaction in the brain very poignantly. A must-read!

Let’s look at another question we see regularly.

Can CBD help with Serotonin Syndrome

First of all, serotonin syndrome is a very serious, life-threatening condition.

Essentially, it’s the result of too much serotonin.

A general explanation and list of symptoms is below but seek medical help immediately if present:

It can start with shivering and diarrhea.

More severe symptoms can follow. Even deadly outcomes.

One note. a common approach to treating Serotonin syndrome in the medical field is the administration of benzos which have their own issues.

Short term, they may be fine but addiction issues can crop up pretty quickly.

In terms of CBD for Serotonin syndrome, we have to be careful since they both use the same P450 pathway in the liver.

Anything that taxes this metabolism pathway can increase levels of SSRI’s.

Some people actually use CBD to reduce the dosages of SSRIs due to this effect.

Usually, your doctor will recommend reducing the SSRI right away (work with your doctor) if they suspect Serotonin Syndrome.

You can check the half-life of the various SSRI’s here at our CBD versus SSRI’s articles.

Here’s the issue.

The common practice for Serotonin syndrome is to stop the SSRI.

This may then lead to SSRI Withdrawal Syndrome which we described above.

Work with your doctor on this. It can be very serious and very fast.

Learn all about the SSRI Syndrome treatment commonly prescribed here:

Just a head’s up. watch out for opioids and SSRI’s combined as there’s a known additive effect between the two of them.

More on that here:

Can CBD be taken with SSRI’s

There isn’t specific research yet on SSRI and CBD taken at the same time.

Yes, we want to take it at least 4 hours apart if taking together. We explained that in our CBD and medications here.

CBD uses the same liver pathway (P450) as most SSRI’s so it may cause their levels to increase in the bloodstream.

There are some reports on Reddit boards where people can reduce their SSRI levels or stop completely (slowly of course) due to CBD’s effect.

This is what we know.

SSRI’s boost serotonin in one direction. up up up and away (until the brain catches up and offsets the increase).

CBD works in the endocannabinoid system to balance serotonin function.

In theory, CBD should help to exercise a check and balance on serotonin functioning.

CBD can boost serotonin when levels are low. (see CBD and serotonin here).

It doesn’t have the side effect profile of SSRI’s (Serotonin Syndrome) even at much higher levels (tested up to 1500 mg in studies).

This points to the fact that it doesn’t boost in one direction.

We want to see hard research on it but you’re not going to get that from pharmaceutical companies where billion-dollar markets are jeopardized.

We can only look at shared pathways at this point.

Again, at least 4 hours apart.

See below for CBD levels to help offset this drop-off.

Can CBD replace SSRI’s

Based on the shared pathways for both (serotonin), replacing SSRI’s with CBD might be an option.

Ideally, you start with CBD before getting entangled in SSRI’s but that’s another article on our health care delivery system!

Make sure to work with your naturopath and know that it is strongly advised not to stop SSRI’s quickly.

A quick review of how I replaced Lexapro:

  • Gradually reduced Lexapro dose over 30 days with pill cutter
  • Tested CBD for 50mg first day to test; opposite time from SSRI
  • Quickly increased to 300mg daily (3 x 100mg after meals)

After this period, I reduced CBD to 100mg daily but some people see much longer periods for serotonin pathways to find grounding.

One note..estrogen and testosterone drive serotonin and there’s no bandaiding the loss of these! See estrogen and mental health as an example.

Best CBD for SSRI withdrawal and replacement

In our experience based on both research of the market and personal trial and error, there are a few considerations in choosing the best CBD for SSRI withdrawal and replacement.

First, the basics:

  • Organically grown in the US
  • CO2 processed (much cleaner end result)
  • 3rd party tested
  • No THC (see THC versus CBD for anxiety)
  • No pesticides
  • No solvents (speaks to the CO2 processing above)
  • No bacteria
  • No mold
  • No heavy metals

Those are minimum requirements and we actually test IndigoNaturals twice to this effect.

Secondly, we need a sufficient level of CBD.

The ideal sweet spot for neurogenesis (which is the basis for SSRI’s effect) in the brain is 300 mg per research.

Beyond that, we still have a dose-dependent effect on anxiety but the neurogenesis effect actually decreases.

For this reason, a good 90% of the junk on the market isn’t going to work.

A 1-ounce bottle with 300 mg is a complete rip-off.

We went through that same process when we originally started.

That’s why we have 2000 and really 6000 mg bottles of CBD.

I personally use the 6000 mg bottle with 1 dropper in the morning and once at night.

One dropper is about 200 mg (6000 divided by 30).

Finally, all the research is on CBD by itself.

Not CBD full-spectrum, hemp oil, or anything else.

For 40-60% of the population, histamine responses to all that plant material are going the wrong direction for anxiety due to serotonin withdrawal.

Histamine is a powerful excitatory chemical in the brain and directly opposes GABA.

It’s simple….we based crafting of IndigoNaturals on research.

Just look at any of our articles (such as CBD and general anxiety disorder or CBD and depression as an example).

We don’t mess around because we’ve suffered ourselves.

We’re out of that now and we want others to understand what’s happening and get relief.

If you’ve been there, you’ll understand why.

One final piece. the real effect of SSRI’s (downstream) may be something you’ve never heard of called BDNF.

More Topics:

Always work with a doctor or naturopath with any supplement!

The information provided here is not intended to treat an illness or substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

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Cbd oil for elderly cats

CBD Oil for Cats: What You Need to Know

As cat owners look for ways to keep their kitties happy and healthy, they’re starting to explore alternative treatments not previously considered by Western medicine. Among these alternative treatments is cannabis oil.

This isn’t much of a surprise, considering that more people are turning to cannabis as a natural treatment for their health issues and research studies have consistently shown the plant’s positive impact on inflammation and other ailments. However, as studied as cannabis’s effect on humans may be, there have been no official major scientific studies into its impact on pets.

So, is cannabis safe for cats? And what sorts of ailments might it treat?

What Is CBD Oil?

Cannabis plants contain more than 100 active compounds, but the one most often used for medicinal purposes is cannabidiol, or CBD. CBD differs from cannabis’s major active compound, tetrahydrocannabinol (THC), in that it does not have a psychoactive affect, meaning it will not get users “high.” CBD oils contain a high concentration of CBD and can be used for therapeutic purposes.

“There are not many classical medical studies that explore the effects of CBD oil in cats,” says Dr. Daniel Inman, a veterinarian at Burlington Emergency Veterinary Specialists in Williston, Vermont. “While we don’t recommend CBD oil for our patients, holistic veterinarians are using it to treat a variety of ailments, including inflammation, anxiety and pain.”

Inman is careful to specify that CBD oil is often used to subjectively increase comfort and improve quality of life in pets, not necessarily cure ailments. This type of treatment should be advised by your veterinarian and not initiated without their consent.

Is CBD Oil Safe for Cats?

Although there have been no scientific studies that specifically investigate the impact of cannabis on pets, Dr. Gary Richter, a holistic veterinarian and owner and medical director of Montclair Veterinary Hospital and Holistic Veterinary Care in Oakland, California, says that CBD oil is generally safe for cats. However, there can be some adverse effects to giving your cat CBD oil, including gastrointestinal upset and some sedation, both of which can be relieved by discontinuing the use of the oil.

“I think the bigger issue, from a medical perspective, is making sure that animals are dosed appropriately. This means that the CBD oil is having the affect you want it to have, and that you’re not accidentally overdosing,” he says.

Dr. Liza Guess, a clinical assistant professor at the Ohio State University Department of Veterinary Medicine in Columbus, Ohio, says that the lack of official, documented research into the affects of cannabis products for cats would make her hesitant to recommend them.

“I have heard that, in humans, marijuana products can be used for neuropathic pain, intractable seizures, anxiety, and appetite stimulation. I have plenty of medications in each of those categories [that are not cannabis] that have been safely used in cats for years that I am very comfortable using and understand well,” she says. “These medications have gone through rigorous studies and are approved by the FDA. Why would I want to use a poorly understood treatment that I can’t guarantee is safe or even effective?”

She adds that the FDA does not regulate the CBD products that are available on the market, so consumers can’t be sure that they’re giving their pets the dosage that they think they are.

“Pet owners looking to give their animals CBD oil should do their due diligence before purchasing anything online,” Richter says. “The marketplace is very much a ‘buyer beware’ environment, and people should be sure that the product they’re buying has been laboratory tested for both content, as well as contaminants like bacteria, fungus, and heavy metals.”

Also, it’s worth nothing that while CBD oil is typically quite safe for cats and dogs, cannabis plants are not. “There is plenty of documentation of marijuana toxicity in cats, for those that nibble on the plants,” Guess says.

Inman adds that as an ER veterinarian, he often sees marijuana toxicity in the animals that come into his practice. “You can usually tell if a pet has gotten into someone’s marijuana. And, in more severe instances, I have had to hospitalize animals until the affects have worn off.”

Is CBD Oil Legal?

Regardless of how well CBD products work for cats, there is also the issue of legality. If a cannabis product contains less than 0.3 percent THC, it’s classified as “hemp,” which is not a restricted substance. Most, if not all, CBD oil fits this description. The bigger issue is discussing this course of treatment with your veterinarian.

“In a perfect world, your veterinarian would be able to discuss this treatment as an option for your pet, but depending on where you live, your veterinarian may or may not be legally at liberty to have this conversation with you,” Richter says. “Even if you live in a state where cannabis is legal, it can be illegal for a veterinarian to tell a pet owner how to appropriately use these products.”

There are activists looking to change these laws, Richter among them.

“For example, there’s a bill being brought to the California State Legislature to debate the use of medical cannabis for animals and veterinarian involvement,” he says. “There’s a very robust conversation going on right now about it whether or not veterinarians should be able to discuss and recommend cannabis for their patients, and, if so, exactly what that looks like.”

Being able to discuss all types of treatments with your veterinarian is key, and Richter advises checking in with your vet before giving your pet any sort of cannabis. “There’s no reason to ever start giving any kind of medication or supplement without having a conversation with your veterinarian first,” he says.

Cbd oil for elderly cats

Although talk of CBD has been around the use for humans and dogs, cats are just as much a part of our family – so that brings up a big question: Can CBD help them live their best lives, too? There are a lot of reasons to think the answer may be yes.


All animals have an endocannabinoid system, and it plays a big role in keeping them healthy. The body produces endocannabinoids, substances much like the cannabinoids found in cannabis. These travel the bloodstream and attach to cells throughout the body to deliver messages and instructions that tell it what’s going on and how to react. Almost every bodily process is affected by these endocannabinoids.

That’s how CBD works. It takes the place of these endocannabinoids. When they aren’t delivering the instructions we need them to, or when the system is under more stress than normal, then CBD can help bring everything back to a state of homeostasis.


Cats have an endocannabinoid system, too. So it’s hardly a stretch to think that CBD can help them with things like anxiety, stress, inflammation, and pain in the same way we’re finding out it helps the rest of us . And we do see and hear lots of anecdotal evidence to back up the idea—from stories about unpettable cats turning in snugglebugs to reports of arthritic felines getting their mojo back.

Still, we can’t say for 100% sure because there just isn’t any long-term studies (yet!) to confirm our suspicions. We do know that CBD appears to be as safe for cats as it is for dogs . One project found large doses could cause side effects but said THC contamination was probably to blame. That same study also found that CBD was absorbed and eliminated differently in cats than it was in pups, which may mean modifying our doses for cats.


CBD’s main claim to fame is it’s ability to decrease inflammation and thus decrease chronic pain in mammals. Researchers at Cornell University fount that CBD oil is great at treating pain because they taret a receptor called the ‘villanoid receptor’ and prevent it from turing on.

CBD is also an excellent neuroprotector which makes it great at treating neurological disorders like seizures and epilepsy.

Other ways in which CBD can benefit cats is by helping with their:

  1. Anxiety
  2. Pain
  3. Inflammation
  4. Seizures/ Epilepsy
  5. Arthritis
  6. Inflammatory bowel disease
  7. Urinary Tract
  8. Overall Wellness


CBD oil for cats usually comes mixed with a few other ingredients to help make it more palatable and nutritious. Often times human or dog CBD is mixed with coconut oil. Unfortunately, cats can’t process the healthy fatty acids found in plants like coconuts (that’s because they’re carnivores.

So look for CBD oils containing sardine oil instead, like Austin and Kat’s Purrfect Feline Formula. And if you must use a coconut oil-based CBD, make sure you get a concentrated one so your furry friend isn’t ingesting too much.


We recommend giving a dose of 2-4 mg of CBD per 10 pounds for cats to start. This is twice the amount we recommend for dogs, but don’t fret. Cat’s don’t have as many cannabinoid receptors as dogs so they need twice the amount to see the same effects. For cats with cancer or seizures, start with 4-6mg of CBD per 10 pounds.

The more difficult the condition, the more CBD you’ll need. But start small and go up until your furry feline is feeling happier and calmer. A little less, or even a little more oil won’t do any harm. Dosing can easily remain approximate until you’re able to find what works best for your cat.

Charlie, or Char-Char, for example, is a lazy 25-pound orange tabby cat. He would have a starting serving of 5mg of CBD and can increase to 10mg if 4mg is not enough for him.

Just remember – It takes about 15-45 minutes to reach full-effect in your pet’s system and lasts for about 4 – 6 hours, depending on breed, ailments, activity level, and their own personal chemistry.