Best CBD Oil for Migraines & Headaches: Benefits, Dosage, & Side-Effects
Migraines can turn an otherwise normal day into a complete write-off — and they’re notoriously hard to treat.
CBD may help by regulating serotonin release, fighting inflammation, controlling vascular spasm, and more.
Migraine headaches are the most common neurological disorder in the Western world . They affect roughly 6% of males and 18 % of females every year.
Most of the treatments for migraines involve prophylactic and/or symptomatic support rather than addressing the underlying cause.
One of the best candidates as a new, effective treatment for migraine headaches is cannabidiol (CBD) from the hemp plant.
In this article, you’ll learn how CBD can help with migraines, how much CBD oil to use, and where to find the best CBD oils for cluster headaches and migraines.
MEDICALLY REVIEWED BY
Carlos G. Aguirre, M.D., Pediatric Neurologist
Updated on November 13, 2021
Table of Contents
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|Cost per mg CBD:||$0.12 – $0.18|
Best CBD Oils For Migraines
- Royal CBD Oil— Best CBD Oil For Migraine Headaches
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- Endoca CBD Oil— Best CBD Oil For Migraines (Europe)
Can CBD Oil Help With Migraines?
One of the most common traditional the cannabis plant is for treating headaches.
Over the past few years there’s been a lot of research exploring the impact of CBD and other cannabis-derivatives for treating migraines and other forms of headaches.
Hemp extracts have so far been proven effective for chronic headaches , migraine headaches , headaches resulting from medications , cluster headaches , intracranial hypertension , and multiple sclerosis neuropathic head pain (trigeminal neuralgia) .
CBD (cannabidiol) is the primary compound responsible for the painkilling benefits of the plant and the most relevant compound for the anti-migraine effects.
Other related compounds (called cannabinoids) offer additional support. The best CBD oils for migraine headaches are made from a full-spectrum extract that contains a variety of active ingredients — such as CBG (cannabigerol), CBC (cannabichromene), THC (tetrahydrocannabinol), and several hemp-derived terpenes.
All of these compounds work alongside CBD to support the painkilling effects of CBD and provide other anti-migraine benefits.
Some of these compounds prevent the release of serotonin from platelet cells (one of the main causes for migraine attacks), others regulate inflammation and blood flow to the brain.
The benefits of CBD oil for migraines include:
- May prevent serotonin-related causses
- Inhibits brain inflammation
- Prevents or alleviates vascular spasms
- Alleviates head pain
1. May Prevent Serotonin-Release (Cause For Migraines)
We’ve long known about the ability for cannabis to inhibit the release of serotonin from the platelets .
This effect could help prevent and treat migraines caused by excessive serotonin release from platelets — which is one of the predominant theories for the underlying cause of migrane attacks (more on this later).
Interestingly, this same effect on serotonin release is also considered one of the primary ways CBD can be used to treat nausea and vomiting, which are also common symptoms associated with migraine headaches.
2. Inhibits Brain Inflammation
One of the ways marijuana was used in the past to treat headaches, was by wrapping its wet leaves around the head and neck for several hours at a time . This practice, mainly documented among the Sumerians, is most likely a direct result of these anti-inflammatory effects.
Modern treatments of migraines often involve anti-inflammatories such as Aspirin or Tylenol.
CBD exerts its effects through a number of different anti-inflammatory mechanisms including adenosine  and NF-kB . Both of these inflammatory channels are considered the primary causes of migraine headaches.
3. Reduces Vascular Spasms
The trigeminal nerve is responsible for causing the vascular system in the brain to spasm out of control — causing cluster headaches and migraines.
One of the main reasons this happens is hyperactivity involving the N-methyl-D-aspartate (NMDA)/glutamate system. This system is responsible for causing many of the stimulating activities in the brain.
It’s like the gas pedal in the car. Once activated, RPM increases and the car goes faster.
In the brain, it’s very similar — when NMDA is active, your neurons fire faster and faster.
Much like a car, the brain also has a brake pedal. We call this Gamma-aminobutyric acid – or GABA. It slows us down and helps us relax, directly opposing the effects of NMDA.
In some cases, NMDA activity can go out of control, causing the trigeminal nerve controlling the vascular system in the brain to go haywire and spasm. This results in severe migraine headaches, which can last hours on end.
CBD slows this process down by stepping on the brake pedal (GABA) , similar to Valproic Acid, slowing everything down, and stopping the arterial system spasm.
4. Alleviates Head Pain
CBD is a master modulator. This means that it doesn’t work on any single pathway, forcing it in one direction or another.
This effect allows CBD to help regulate how much pain we perceive. Like playing with the volume control on your speaker system it can help “turn down” the volume on pain.
When we experience migraine headaches, the pain volume is cranked all the way up.
CBD helps promote the processes that are meant to control this by telling some of the responsible receptors (such as the TRPV1 and opioid receptors) to step up and turn the volume back down to an appropriate level.
There are 10 times as many CB1 receptors as there are mu-opioid receptors in our central nervous system and pain pathways [16,17]. This means the CB1 endocannabinoid receptors are likely a key regulator of pain sensation within the brain, and intimately involved with the regulation of migraine or cluster headache-related pain.
What’s the Dose of CBD Oil for Migraine Headaches?
Dosing CBD can be a challenge, especially since it tends to react differently in everybody.
For some people, a small dose is all that’s needed to produce effects, while others need much larger doses. This can make dosing difficult at first, but once you understand how it works in your body, it’s very straightforward.
There are some general CBD dosage guidelines you can follow for figuring out the right dose to start with, and how to dial it effectively.
With that said, it’s important to note that many people who are prone to migraines tend to be more sensitive to chemicals. For this reason, we recommend starting slightly below the lowest recommended dosage for your weight and build up slowly from there.
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How Long Should I Use CBD Oil for Migraines?
The key to using CBD oil effectively for migraines is to use it regularly over long periods of time, in addition to your routine prescriptions.
By taking small doses of the oil throughout the day – usually once in the morning and once in the evening — you’ll be able to improve your body’s natural ability to maintain neurovascular balance and avoid spiraling out of control into a debilitating migraine attack.
Many people taking CBD oil for this will increase the dose when they feel a migraine attack coming on to stop it in its tracks or reduce its overall severity.
For example, a migraine sufferer might take 5 mg worth of CBD in the morning and 5 mg in the evenings most days. When they feel a migraine coming on, they take another 5 mg every 2 or 3 hours until it subsides. However, you should also keep taking your prescription medications for prevention and treatment.
What are Migraines?
Migraines are a type of severe, recurring headache accompanied by at least one, or various, physical symptoms such as nausea, vomiting, and sensitivity to light or sound.
In many cases, these headaches only affect one side of the head and cause throbbing pain. They may also be agitated by movement, and are of enough intensity to interfere with daily function.
Migraines typically last 4-8 hours (typically all day), but can last as long as three days (72 hours).
Along with headaches, migraine sufferers also commonly experience other symptoms such as nausea, sensitivity to light, sound, and smells, as well as visual disturbances.
Four Phases of Migraine Headaches
Migraines tend to have distinct phases. These aren’t always present, and they can vary a lot from one episode to the next.
Phase 1: Prodromal Phase
This phase can begin either days, hours, or minutes before a migraine attack — it’s a common warning sign that a migraine is soon to ensue.
It may involve a wide variety of symptoms that appear before the actual headache. People with chronic migraines tend to learn what their triggers and early symptoms usually are. These feelings should prompt people to take their preventive medications.
Some common symptoms of the prodromal phase include:
Phase 2: Aura Phase
During the aura phase, people experience strange changes in their vision and/or perception. It can change the way colors look, how we interpret smell and taste and can alter our mood dramatically.
The aura phase typically lasts about 1 to 2 hours.
For most people who experience regular migraines, this is the most reliable indication that they are about to have an episode. Some people can even estimate how severe their migraine will be from the severity of the aura phase.
Symptoms of the aura phase can include:
- Vision disturbances
- Changes in perception of taste, light, smell, sound, and touch
- Speech or language problems
- A spinning sensation
- Muscle weakness
- Auditory or visual hallucinations
Phase 3: Pain (Headache) Phase
This is the main phase we think of when we talk about migraines.
This phase can vary a lot in severity and is usually very unpredictable, even in people who have regular episodes of migraine headaches.
In most cases, migraine headaches only affect one side of the head but can affect both sides equally as well. Some people feel the pain at the front of the head, others at the back, and some in the center.
However, if you suddenly experience the worst headache of your life that feels like a clap of thunder all over your head, or have had a migraine for over 72 hours, please go to your nearest emergency department right away.
Symptoms of the pain phase include:
Phase 4: Postdrome Phase
The postdrome phase happens after a migraine has settled.
Many people who experience these say they resemble a hangover but can last for several days. Some will even feel pressure or low-grade pain in the places where most of their migraine affected.
It can leave people feeling fatigued and depressed for a few days after the event.
In some cases, people may find that during this phase they feel unusually refreshed and clear-headed. Some reports even suggest a euphoric state for as long as a week after the event.
What Causes Migraine Headaches?
Migraine headaches tend to be very elusive to researchers. They’re hard to predict and even harder to trace back to any particular cause. Migraine headaches tend to be very elusive, however, researchers today have a better understanding of the basis of migraines.
From stress and hormone levels to allergies and chemical exposure — these are all considered factors and potential causes for migraines but can vary a lot from one person to the next.
Common Migraine Triggers
- Mental — Stress, emotional upset
- Endogenous — Hormonal changes, fasting, fatigue, sleep disturbances
- Exogenous — Certain foods (chocolate, wine, aged cheese, etc.), alcohol, smoke, allergens, nitrates, oral contraceptives, glutamate, tyramine
- Other — Weather, bright colors, odors, temperature changes, altitude
One of the main factors new research is investigating is hormone levels.
This is because migraines are more common in young boys just before puberty and 2 or 3 times more likely in women than men. Additionally, migraines tend to decrease during pregnancy and menopause.
All of these factors can be traced back to fluctuations in hormone levels, though scientists still don’t know exactly how this works, but there are several strong theories as we’ve listed below.
There are several prominent theories at play  which are most likely the actual causes of hormone-related migraines including:
- Serotonin/platelet theory
- Sensitization of peripheral and central brain areas from inflammation
- Muscular spasms of the veins and arteries
Let’s cover some of the main ones now and how they’re correlated with CBD.
1. Serotonin & Platelet Theory
Serotonin is a neurotransmitter and has many roles in the body. It regulates much of our emotion, sexual function, hormone balance, and memory.
One of the leading theories for the cause of migraines is an excessive release of serotonin from platelet triggers.
What does this mean?
A platelet is a type of cell that floats around in the bloodstream and plays an important role in the way we monitor and control coagulation and inflammation in the body — among other things. One of the ways we do this is by releasing small amounts of serotonin.
In some cases, these platelets can overreact to the situation and dump large amounts of serotonin into the bloodstream, causing blood vessels to widen and lose pressure. This essentially causes regions located near the area to go into shock .
When this happens in the blood vessels of the brain, it can cause the widening of blood vessels and release of inflammatory signals causing symptoms such as severe pain, disorientation, and hypersensitivity to stimuli like sight and smell.
What this means: If we can stop the excessive release of serotonin from the platelet cells, we may be able to stop or prevent migraine headaches.
2. Inflammation (Sensitization)
We need inflammation to stay healthy.
It’s our bodies’ way to trap and destroy invading bacteria and viruses. Inflammation promotes healing and prevents further damage to the body by causing pain and redness which reminds us to be careful with that part of the body.
Unfortunately, inflammation can go out of control causing many different health problems for the body.
One such problem is migraine headaches.
A protein found inside the cells, known as nuclear factor kappa B (NF-kB for short) is responsible for regulating the creation of inflammatory compounds in the cells.
NF-kB is a major driving factor behind migraine headaches. When this protein goes out of balance, it can cause an overabundance of inflammatory messengers called cytokines (IL-1B, IL-6, and TNF-a). These messengers then trigger a wave of inflammation and pain in the nervous system. .
Since these messengers are short-lived, the problem usually subsides within several hours, causing the migraine to typically last all day, and before gradually disappearing.
This cause is especially common in people who tend to be over-reactive to foods and other allergens. People who suffer from asthma and hay fever are also at a higher risk for migraines caused by this effect.
What this means: If we can stop the overactivation of NF-kB, we may be able to prevent migraines.
3. Muscular Spasms of the Veins and Arteries
All of our arteries have a thin layer of muscle lining them.
These muscles are designed to expand and contract to control our blood pressure and to allow us to shunt blood into vital organs such as the brain when need be.
A good example of when do this is when we’re out in the cold.
To preserve the core body temperature, the blood vessels in our hands, feet, and nose will tighten to slow blood flow in the area. This helps to keep the warm blood closer to the internal organs.
There are other reasons for shunting blood as well, such as after a meal when we need more blood flow to the digestive organs or after a traumatic injury where we need to bring fresh oxygen and nutrients to the damaged site.
This system is especially sensitive in the delicate regions of the brain.
When the trigeminal ganglion is activated by the cortical spreading depression, it releases pro-inflammatory molecules onto] the muscles controlling its blood vessels that can widen and spasm, causing severe migraine headaches.
What this means: If we can stop excessive vascular spasms among the arteries feeding the brain, we can stop migraines.
How Are Migraine Headaches Treated?
Treating migraines focuses on both prevention as well as treatment, but still involves a lot of trial and error, as well as time due to everyone’s unique chemistry.
This is because the medications used to address any of the three causes of migraines are different, and it takes up to 6 weeks for a medication to build up enough to have any effect.
Most of the drugs for migraines have about a >50% chance of working after several weeks. If one medication doesn’t work, doctors will usually move on to another one. If your migraines happen 15 or more days per month, then scalp botox injections are also an effective new, insurance-covered prevention option.
Most people who suffer migraines will use [their preventive medications and prescriptions. However, milder migraine sufferers may use] over the counter pain medications such as Excedrin, Tylenol, Ibuprofen, and Aspirin, however, this only helps curb the intensity of mild episodes. They do little for actually clearing up a migraine and are rarely strong enough to completely alleviate symptoms. Most often they’re used in conjunction with routine prescription medication.
Treatment Options for Migraine Headaches:
Most of these medications come with a long list of negative side effects such as ulcers, heart vessel spasms, kidney damage. Unfortunately for some people, there is only minimal relief available from migraine headaches.
For this reason, many people who suffer recurrent migraines are turning for help from a different source of medicine. It’s important to note that many medications interact with CBD and other alternative treatments.
Herbal Medicine for Migraines
There are obvious benefits to conventional medicine over plant-based medicine. However, this is not the case for migraine headaches.
There are many herbs with well-established benefits of treating and preventing migraine headaches.
Feverfew, for example, is a small plant in the daisy family that offers direct improvements on all three processes thought to be causing migraine headaches .
Another plant that has shown significant potential in addressing the causes and symptoms of migraine headaches is the cannabis plant.
Plants such as these often contain dozens, if not hundreds of different chemicals. Unlike pharmaceuticals, this makes it difficult to characterize each compound’s precise effects, giving them the added benefit of providing what we could call a multifaceted approach to treatment.
This means that the series of chemicals contained in cannabis may possibly offer similar benefits for a medical condition, but do it through different mechanisms.
For example, the cannabis plant contains as many as 80 different cannabinoids and well over 100 different terpenes in its leaves and resin.
Some of these cannabinoids help to stop arterial spasms, others stabilize immune cells and more.
By providing multiple therapeutic avenues for a particular condition, and by sharing many common underlying mechanisms, cannabis could potentially stand a better chance of fixing the problem.
This is a common technique oncologists use to fight cancer. By using a cocktail of chemotherapeutic drugs, each with slightly different modes of action, they get a far greater chance of choosing the right one and curing their patient’s cancer.
Key Takeaways: Can CBD Oil Help With Migraines?
Migraines are many things— common, debilitating, and mysterious.
Doctors and neuroscientists still don’t have a definitive explanation for what causes them or how to stop them.
There are, however, a lot of promising theories that we can start with when looking for treatments for the condition. From what is known, there are common pathways that CBD may also act upon to help.
CBD oil has recently been on the rise as a new and potentially effective migraine treatment and prevention method. It works through several different yet related pathways to resist the processes driving migraine headaches.
It’s likely that we’ll see this use of CBD and CBD oil become a standard adjunctive treatment for the condition in the next few years as more research sheds light on the incredible benefits of this humble plant extract.
The Ultimate Guide for Using CBD for Headaches
CBD is a popular option for people looking for natural ways to treat pain and discomfort, including chronic headaches and migraines. When creating a CBD oil for headaches treatment plan, you’ll want to follow the steps outlined below:
How to Use CBD for Headaches
- Decide on Topical or Oral CBD
- Figure Out Dosage
- Rest and Evaluate
CBD is a medicinal cannabis compound extracted from hemp plants (genus cannabis) with minimal or no THC content. It works in the body by regulating and protecting the endocannabinoid system, which influences inflammation, pain, sleep, and more.
Studies have shown that the therapeutic benefits of CBD for headaches could be more than previously thought, as it may help to reduce the pain associated with headache and migraine conditions. In a recent medical study , those who received CBD reported a significant reduction in the amount of headache pain than those who were not given CBD.
Can CBD Help with Headaches?
Because a migraine headache is so common and debilitating, there have been many clinical trial research studies performed to find an effective treatment for reducing the incidence of migraines and lessen the migraine pain. One therapy that’s becoming increasingly popular is using CBD for headaches.
A study on the use of medical marijuana for a chronic migraine was published in the journal Pharmacotherapy in 2016. Researchers discovered that 39.7 percent of the 48 persons polled said they had fewer migraine bouts overall. The research reported that the frequency of chronic migraines in a group of medicinal marijuana users was reduced from about 10 per month to only around four per month. And according to research presented at the European Academy of Neurology’s Congress in 2017, CBD may reduce migraines and relieve the agony of migraine headaches, according to research
How Does CBD Oil Help with Headaches?
A tension headache is a common condition that causes severe pain behind the eyes, around the temples, or in the back of the head. It can be triggered by anything from stress and lack of sleep to sinus problems and menstruation. The pain can vary from mild to severe, and sometimes it’s hard to tell what’s causing it in the first place. CBD is thought to lessen the nerve pain by attaching to glycine receptors in the brain, which control how quickly nerve signals flow between nerve cells.
The benefits of CBD for a severe headache are many, and range from mild to long-term relief. Individuals with a history of addiction to other substances may also take advantage of CBD for a headache as it’s not addictive, making it a safe option to consider if you need to stop taking an over-the-counter or prescription medication for pain.
There have been studies of the dulling effects CBD has on pain. By interrupting the messages from the brain to the body, the user doesn’t feel the pain as an acute migraine. Not surprisingly, roughly four out of 10 men and women who use CBD products, say they use them for migraine relief.
CBD oil may also help with long-term relief by reducing migraine symptoms that have been long-term triggers for the individual. For example, people who regularly experience chronic pain tend to have a heightened sense of anxiety; this is not only unpleasant, but it can take a serious toll on overall mental health.
CBD oil has been shown to be an effective anxiety treatment. This is because CBD may help balance out the brain’s endocannabinoid system, producing naturally occurring chemicals, like anandamide. CBD oil may also positively affect certain types of headaches, such as a chronic migraine or cluster headache.
Is CBD Safe for Headache Use?
CBD, unlike THC, doesn’t produce a euphoric high or psychoactive effect, making it less contentious and safer for medical use. CBD oil has proven to be useful in treating a variety of conditions; detailed in a number of health studies.
CBD is a great, natural alternative to traditional medication because it has minimal side effects. If you’re uncomfortable with the idea of using marijuana, CBD oil is a great option because it can give you similar migraine relief without the psychoactive high. It’s available in various strengths from different CBD brands or health stores.
CBD oil products made from CBD have become increasingly popular in the medical market because of their functional wellness benefits. CBD has a calming effect on the nervous system, and some users of CBD oil have reported benefits like relief from chronic headaches.
Just like any other type of natural medication, CBD oil does not have to be taken in large quantities to be effective. You need just the right amount of CBD in your system for the proper dose to work.
How to Use CBD for Headaches
1. Decide On Topical or Oral CBD Usage
Oral applications and topicals are the two of the most popular ways people take CBD. According to the National Institute on Drug Abuse (NIDA), people can take CBD by ingesting it in beverages or edible CBD products, like CBD gummies , tinctures , or soft gel capsules . There are also topicals you can apply directly to your skin, such as salves and lotions.
Topical CBD creams are one of the most popular ways to enjoy the therapeutic effects of CBD. After you apply the lotion or salve, your body absorbs the CBD oil through its skin.
CBD topicals deliver the primary benefits of CBD to your body through two main mechanisms:
- Cannabinoids bind with receptors near pain pathways and block out pain signals.
- CBD works on many levels, including reducing swelling and inflammation.
When applied topically, substances that interact with the CB2 receptors in our bodies can help relieve pain, which is why many people often use topical CBD creams for arthritis pain, soreness, or other chronic conditions.
When you apply CBD topicals directly to the skin, it can help reduce swelling and other migraine symptoms associated with inflammation.
Oral CBD Usage
CBD can be prescribed by a doctor in pill form or taken through a tincture oil. Taking CBD orally implies consuming CBD through the mouth. There are two ways to orally ingest CBD for headaches:
This approach, often known as “under-the-tongue,” involves placing droplets of CBD oil tinctures beneath your tongue and holding them there for 30 to 60 seconds before swallowing. CBD is absorbed through the capillaries in your mouth, entering the circulation and finally reaching the ECS’s cannabinoid receptor.
Compared to other CBD applications, this CBD consumption technique offers one of the greatest bioavailability percentages. Because CBD molecules are delivered directly into the bloodstream through the mouth’s mucous membranes, they avoid being processed through the first-pass metabolism.
Directly swallowing CBD in the form of a pill, candy, soft gel, or other edible ways is referred to as ingesting CBD. When you consume CBD, the molecules must first go through your digestive system and make their way to your liver, where they are first broken down; this is referred to as the first-pass metabolism.
The remaining chemicals are then delivered to the bloodstream once the liver has metabolized the CBD. Therefore, CBD has slightly lower bioavailability when consumed; digestive enzymes break it down into useless components before it reaches the bloodstream. Ingested CBD, on the other hand, appears to still have a long-lasting compared with any other application route.
Which Type of CBD Oil Should I Use for my Headache?
If your migraine pain or discomfort is localized to the temples or the base of your neck, a topical CBD product could be very effective, but if you have whole-body pain or the affected pain area is covered by your head hair, an oral CBD product may be a better option. Don’t be afraid to try both, though, and decide for yourself which one works best for your headache pain.
2. Figure Out Dosage
Your optimal dosage amount of CBD oil will depend on a variety of factors, including weight and metabolism. It is always recommended to start low and go slow when using new medications or supplements. Everyone has an individual tolerance level, which is why the recommended CBD Dosage may range from person to person.
The most common CBD oil dosage is between 25mg to 50mg per day. The amount you take can vary based on the severity of your headache and the length of time you’ve been experiencing migraine symptoms. Keep in mind that you should take it consistently to be effective if you are taking CBD oil for chronic pain.
The effects of CBD may also depend on what type of CBD you are using. For example, if you start with a product at a lower concentration, such as 15 mg per day for three days, and then increase to 30 mg per day for another week or so before increasing again, this will help your body adjust to the effects.
3. Rest and Evaluate
Now that you’ve determined which CBD product to use and how much to consume, it’s time to sit back, rest, and evaluate.
If the CBD treatment is effective, your headache pain will begin to subside and you’ll start feeling more relaxed. If you can, take a nap—the CBD will help you sleep, and it’s a great way to let your brain rest as much as possible.
If you don’t feel much of anything after a couple hours, you may need to try a stronger dose or different consumption method. You may also consider rubbing CBD salve or CBD balm on your temples and neck, which can help relax the muscles and give you relief.
Are there any CBD side effects to watch out for?
CBD has very minimal side effects, but there are a few you might experience if you consume too much or are particularly sensitive to cannabinoids.
The most likely side effect you’ll experience is feelings of sleepiness or lethargy. However, CBD can also cause nausea and diarrhea. Because nausea and diarrhea are common side effects of many other drugs, patients may consider consulting with their doctor if they experience any of them.
You can also minimize side effects by drinking adequate water, eating enough protein, and getting sufficient sleep. Patients who suffer from frequent migraine attacks might need to take more than one dose per day and receive continuous therapy.
Where to Buy CBD Products for Headaches
More and more people are turning to CBD oil to manage chronic headaches and migraines, and for good reason: CBD is an effective treatment for headaches due to its anti-inflammatory, pain-relieving properties. It’s also natural, making it a great alternative to prescription medications.
If you’re ready to try CBD oil for headaches, shop FarmerandChemist.com ’s wide selection of CBD products. We carry only the highest-quality, premium CBD products, and have a team of pharmacists and pharmacy technicians ready to answer any questions you may have about using CBD to treat headaches or migraines.