Posted on

Cornell university cbd oil for dogs

Researchers: Some pet products touted as CBD don’t have any

In this Nov. 5, 2019 photo, in St. Francis, Wis., Amy Carter looks at her Yorkshire terrier-Chihuahua mix Bentley, who has epilepsy. Carter, gives him CBD, which she says has reduced his seizures. The federal government has yet to establish standards for CBD that will help pet owners know whether it works and how much to give. But the lack of regulation has not stopped some from buying it, fueling a $400 million CBD market for pets that grew more than tenfold since last year and is expected to reach $1.7 billion by 2023, according to the cannabis research firm Brightfield Group. (AP Photo/Carrie Antlfinger)

Companies have unleashed hundreds of CBD pet health products accompanied by glowing customer testimonials claiming the cannabis derivative produced calmer, quieter and pain-free dogs and cats.

But some of these products are all bark and no bite.

“You’d be astounded by the analysis we’ve seen of products on the shelf with virtually no CBD in them,” said Cornell University veterinary researcher Joseph Wakshlag, who studies therapeutic uses for the compound. “Or products with 2 milligrams per milliliter, when an effective concentration would be between 25 and 75 milligrams per milliliter. There are plenty of folks looking to make a dollar rather than produce anything that’s really beneficial.”

Such products can make it to the shelves because the federal government has yet to establish standards for CBD that will help people know whether it works for their pets and how much to give.

Still, there’s lots of individual success stories that help fuel a $400 million market that grew more than tenfold since last year and is expected to reach $1.7 billion by 2023, according to the cannabis research firm Brightfield Group.

Amy Carter of St. Francis, Wisconsin, decided to go against her veterinarian’s advice and try CBD oil recommended by a friend to treat Bentley, her epileptic Yorkshire terrier-Chihuahua mix. The little dog’s cluster seizures had become more frequent and frightening despite expensive medications.

“It’s amazing” Carter said. “Bentley was having multiple seizures a week. To have only six in the past seven months is absolutely incredible.”

But some pet owners have found CBD didn’t work.

Dawn Thiele, an accountant in Oak Creek, Wisconsin, said she bought a $53 bottle of CBD oil from a local shop in hopes of calming her 2-year-old Yorkshire terrier during long car trips.

“I didn’t see a change in his behavior,” said Thiele, who nonetheless remains a believer.

“The product is good, it just didn’t work for my dog,” she said.

Short for cannabidiol, CBD is a non-intoxicating molecule found in hemp and marijuana. Both are cannabis plants, but only marijuana has enough of the compound THC to get users high. The vast majority of CBD products come from hemp, which has less than 0.3% THC.

CBD has garnered a devoted following among people who swear by it for everything from stress reduction to better sleep. Passage of the 2018 Farm Bill, which eased federal legal restrictions on hemp cultivation and transport, unleashed a stampede of companies rushing products to the market in an absence of regulations ensuring safety, quality and effectiveness.

Products for people were swiftly followed by CBD chewies, oils and sprays for pets.

See also  Strong cbd oil for dogs

“The growth is more rapid than I’ve seen for any product in 20 years in this business,” said Bill Bookout, president of the National Animal Supplement Council, an industry group whose member companies agree to testing and data-gathering requirements. “There’s a gold rush going on now. Probably 95 percent of the industry participants are responsible, but what’s dangerous is the fly-by-night operative that wants to cash in.”

The U.S. Food and Drug Administration is developing regulations for marketing CBD products, for pets or people. This year, it has sent warning letters to 22 companies citing violations such as making claims about therapeutic uses and treatment of disease in humans or animals or marketing CBD as a dietary supplement or food ingredient.

“It’s really the Wild West out there,” said S. David Moche, founder of Applied Basic Science, a company formed to support Colorado State University’s veterinary CBD research and now selling CBD online. He advises consumers to look for a certificate of analysis from a third-party testing laboratory to ensure they’re getting what they pay for.

“Testing and labeling is going to be a critical part of the future of this industry,” Moche said.

Wakshlag said products must be tested not only for CBD level, but also to ensure they’re free of toxic contaminants such as heavy metals and pesticides and have only trace amounts of THC, which in higher levels is toxic to dogs.

Bookout said his organization has recorded very few health incidents involving CBD and no deaths.

Still, scientific documentation of CBD’s safety and efficacy is nearly nonexistent.

That’s starting to change, however. A small clinical trial at Colorado State University published in the Journal of the American Veterinary Medical Association in June found CBD oil reduced seizure frequency in 89 percent of the epileptic dogs that received it.

A clinical study headed by Wakshlag at Cornell, published in Frontiers in Veterinary Science in July 2018, found CBD oil helped increase comfort and activity in dogs with osteoarthritis.

Stephanie McGrath, a Colorado State University researcher, is now doing a larger clinical trial funded by the American Kennel Club’s Canine Health Foundation.

“The results of our first epilepsy study were promising, but there was certainly not enough data to say CBD is the new miracle anti-convulsive drug in dogs,” McGrath said.

Seizures are a natural focus for research on veterinary CBD products, since Epidiolex, the only FDA-approved drug containing cannabidiol, was approved last year for treatment of two severe forms of epilepsy in children. Veterinarians are allowed to prescribe Epidiolex for pets, but it’s prohibitively expensive — upwards of $30,000 a year for an average-size dog, McGrath said.

The Kennel Club’s chief veterinary officer, Jerry Klein, said CBD is “over-hyped” but promising for treatments like pain relief. He’s hopeful that the growing market will result in more money being invested in research to prove uses.

Meantime, the American Veterinary Medical Association is telling veterinarians they can share what they know about CBD with clients but shouldn’t prescribe or recommend it until the FDA gives its blessing.

“There’s no question there’s veterinary interest in these products as therapies, but we really want to see the manufacturers demonstrate that they’re effective and safe and get FDA approval so we can have confidence in the products,” said Gail Golab, chief veterinary officer for the association.

See also  How to use cbd oil for vasculitis

Ex Vivo & In Vitro Anti-inflammatory Effects of a Mixed CBD/CBDA Hemp Oil Formulation

The anti-inflammatory properties of CBD make hemp oil a promising adjunct therapy in veterinary medicine. A formulation of hemp oil containing CBD and CBDA may have superior antiinflammatory effects than CBD alone. Notably, CBDA inhibits cyclooxygenase-2 (COX-2), attenuating inflammation. However, specific anti-inflammatory effects of a mixed CBD/CBDA hemp oil remain unknown in the dog. This study includes three arms of testing to broadly assess the impact of CBD/CBDA on ex vivo and in vitro inflammatory responses using blood from 6 research colony dogs. First, we will test the effects of CBD, CBDA, and mixed CBD/CBDA (mCBD) on canine neutrophil function ex vivo. PMA-induced reactive oxygen species (ROS) generation, phagocytosis of fluorescent Ig-coated latex beads, and eicosanoid concentrations (PGE2 and LTB4) will be measured with commercially available kits my lab routinely uses. The Boyden chamber method will quantify neutrophil chemotaxis to recombinant canine IL-8. Second, we will evaluate the effect of CBD/CBDA on T cell function. We will measure the proliferative response of mitogen-stimulated T cells producing pro inflammatory (IFNgamma, IL-2, IL-4, IL-10, IL-17) and anti-inflammatory (IL-10) cytokine production ex vivo with optimized canine-specific EliSpot assays. Third, we will measure the effects of CBD, CBDA, and mCBD on canine fibroblast response as resident cells of most tissue types can elaborate eicosanoids and cytokines in response to pathogen components such as LPS from gram-negative bacteria. We will measure the effect of CBD/CBDA on LPS stimulated fibroblast eicosanoid production, cytokine production with a commercially available inflammatory array, and proliferation with the MTT assay in vitro. We hypothesize that the combination of CBD and CBDA will have superior anti-inflammatory effects compared to CBD alone. The proposed study lays the groundwork for future studies evaluating the anti-inflammatory effects of CBD/CBDA in vivo.

Cornell University Study Says Hemp Oil Works For Dogs In Pain

First Of Its Kind Pharmacokinetics Study On Cannabinoids For Dogs

Cornell University Study Says Hemp Oil Works For Dogs In Pain

First Of Its Kind Pharmacokinetics Study On Cannabinoids For Dogs

Cornell University’s College of Veterinary Medicine has just announced the findings of the first ever pharmacokinetic clinical trial on the effects of cannabinoids for dog pain.

The participating dogs in the study were suffering from multi joint pain and osteoarthritis. To conduct the 8-month double blind, placebo controlled study, Cornell collaborated with ElleVet Sciences. ElleVet Sciences was founded in Portland in 2017, and is in the business of creating soft-chew supplements for dogs made from proprietary hemp oil blends.The primary goal of the Cornell-ElleVet study was to understand how dogs metabolized ElleVet Mobility soft chews, which are hemp-based supplements also containing glucosamine and chondroitine, two natural compounds that may improve mobility in dogs with arthritis. Glucosamine and chondroitin are already being widely used by arthritic humans.

According to a press release, over 80% of the participating dogs in the study who used the ElleVet Mobility chews saw significant improvements compared to those who received a placebo. Vets who were involved in the study referred to the product as “a game changer that will change the face of veterinary medicine.”

See also  Cbd oil for intestinal issues

The study was led by Dr. Joseph Wakshlag, Cornell associate professor and a veterinarian. He wrote a letter to the vet community recommending the product, saying that it had “very promising initial results” and that the researchers will continue analyzing if it has the potential to treat oncology and post-surgical pain. The letter also states: “Over the past 8 months we have conducted a pharmacokinetic and clinical trial on the efficacy of ElleVet Sciences CBD preparation on Osteoarthritis. To date our findings have confirmed that their product is safe and efficacious for pain in dogs with osteoarthritis, chronic joint pain and geriatric pain and soreness with dramatic beneficial effects in our more geriatric patients.”

ElleVet Mobility soft chews are available in 2 sizes for dogs above and below 50 pounds. The chews can only be prescribed by a veterinarian, and are safe to mix with non-steroidal anti-inflammatories (NSAIDS). The drug isn’t addictive and doesn’t get dogs high, but as precaution should be kept out of children’s reach.

The Cornelle-ElleVet partnership is also currently studying how hemp oil affects cats using a product called ElleVet Feline.

CBD for Pet Care

Dogs and cats also have an endocannabinoid system, just like humans. While much more research is necessary for us to fully understand how cannabis works in pets, there are already several CBD products on the market for dogs.

CBD has been promising so far in treating a wide range of ailments that dogs suffer from. For example, while we humans suffer from Alzheimer’s, the same condition in animals is known as Cognitive Dysfunction Syndrome. This disease is characterized by reduced functioning in the brain due to more plaque and microglia deposits, which lead to inflammation.

CBD can also protect the brain of aging dogs thanks to its neuroprotective, antioxidant, and anti-inflammatory properties. Studies show that when animal models were administered with cannabinoids, they still performed better in tests despite the presence of plaque in their brain. Researchers found out that this is because cannabinoids help activate microglia, which decreases inflammation and preserves mental function.

Pets also suffer from anxiety, another condition that CBD can treat. Pets are more prone to anxiety when they face separation from their owners, have to leave home, or encounter people or situations that they aren’t familiar with. Other factors such as thunder and fireworks can also cause severe anxiety in dogs, but CBD can help.

Even though science proves that CBD is safe for dogs, pet owners also need to proceed with caution should they wish to medicate their dogs with cannabis-based products.

According to Dr. Gary Richter of the Montclair Veterinary Hospital in Oakland, California, THC overdosing is still a concern. “Depending on how significantly a pet has been overdosed, the effects of that can be quite long-lasting, even days,” he says. However, he says that it’s “exceedingly rare” for dogs to suffer from life-threatening risks from cannabis. He also adds that the risk is greater when the pet consumes edibles that contain chocolate, raisins, or coffee

“Even if the THC toxicity is not excessive, they can sometimes have problems due to these other ingredients,” Richter says.

Pet owners should always consult a veterinarian if they wish to treat their dog with cannabis in any form.