CBD-enriched cannabis for autism spectrum disorder: an experience of a single center in Turkey and reviews of the literature
Introduction: Autism spectrum disorder is a neurodevelopmental disorder characterized by deficits in communication, social interaction, restricted interest, and repetitive behaviors. Although more cases are being diagnosed, no drugs are approved to treat the core symptoms or cognitive and behavioral problems associated with autism. Therefore, there is an urgent need to develop an effective and safe treatment.
Objective: In this study, we aim to share our 2-year experience with CBD-enriched cannabis treatment in autism and review the latest studies.
Materials and methods: The study included 33 (27 males, six females) children diagnosed with autism spectrum disorder who were followed up between January 2018 and August 2020. The mean age was 7.7 ± 5.5 years. The average daily dosage of cannabidiol (CBD) was 0.7 mg/kg/day (0.3-2 mg/kg/day). The median duration of treatment was 6.5 months (3-28 months). The preparations used in this study contained full-spectrum CBD and trace elements tetrahydrocannabinol (THC) of less than 3%.
Results: The outcomes were evaluated before and after treatment based on clinical interviews. At each follow-up visit, parents were asked to evaluate the effectiveness of the CBD-enriched cannabis treatment. According to the parents’ reports, no change in daily life activity was reported in 6 (19.35%) patients. The main improvements of the treatment were as follows: a decrease in behavioral problems was reported in 10 patients (32.2%), an increase in expressive language was reported in 7 patients (22.5%), improved cognition was reported in 4 patients (12,9%), an increase in social interaction was reported in 3 patients (9.6%), and a decrease in stereotypes was reported in 1 patient (3.2%). The parents reported improvement in cognition among patients who adhered to CBD-enriched cannabis treatment for over two years. The antipsychotic drug could be stopped only in one patient who showed mild ASD symptoms. No change could be made in other drug use and doses. Additionally, this study includes an extensive review of the literature regarding CBD treatment in autism spectrum disorder. According to recent studies, the average dose of CBD was 3.8±2.6 mg/kg/day. The ratio of CBD to THC in the used preparations was 20:1. The most significant improvements were seen in the behavioral problems reported in 20-70% of the patients.
Conclusion: Using lower doses of CBD and trace THC seems to be promising in managing behavioral problems associated with autism. In addition, this treatment could be effective in managing the core symptoms and cognitive functions. No significant side effects were seen at the low doses of CBD-enriched cannabis when compared to other studies.
Keywords: Autism spectrum disorder; Cannabidiol; Cannabis.
CBD Oil and Autism: What Parents Need to Know
CBD oil is becoming an increasingly popular treatment option for a variety of health conditions – including autism. But is CBD oil a safe autism treatment for kids?
Nicole Harris joined the team in 2018 as a staff writer and was promoted to SEO editor in 2021. She now covers everything from children’s health to parenting trends. Her writing has appeared in Martha Stewart Weddings, Good Housekeeping, The Knot, BobVila.com, and other publications. A graduate of Syracuse University, Nicole currently lives in Queens, New York with her husband.
Autism is a neurological disorder impacting social skills and development. It affects one in 40 American children today, according to a December 2018 report from the American Academy of Pediatrics. Many children with autism have difficulty interacting with others, and some display unusual patterns of behavior like ritualistic motions. Individual cases of autism fall on a spectrum ranging from mild to severe.
Doctors don’t know the cause of autism, but environmental and genetic factors may play a role. There’s also no cure for autism; however, a variety of interventions (like occupational and speech therapies) can lessen the severity of symptoms. One of the newest and most controversial treatment options is cannabidiol (CBD) oil, a natural substance extracted from cannabis.
CBD oil is made without large amounts of tetrahydrocannabinol (THC) – the chemical that’s responsible for the psychedelic effects of marijuana – so it can’t technically get you “high.” It has become widely available in health food stores and medical marijuana dispensaries across the country – usually in liquid, cream, or gel capsule form.
In preliminary studies, CBD oil has been shown to improve a variety of physical and mental health conditions like chronic pain, anxiety, ADHD, gastrointestinal illness, insomnia, cancer, and more. And in an April 2018 study of 60 children published in Neurology, a group of Israeli researchers found that CBD oil reduced autism-induced behavioral, communication, and anxiety problems.
Parents across the country have hopped on these findings and starting giving CBD oil to their children. Many claim CDB oil helps regulate emotions, promote better sleep, and control autism symptoms.
As with every new medical breakthrough, though, CBD oil isn’t without drawbacks. According to Mandi Silverman, PsyD, MBA, senior director of the Autism Center at the Child Mind Institute, there’s a lack of information about using CBD for behavioral disorders, especially in young children. That’s why Silverman and many other health professionals suggest parents learn the facts before stocking up on CBD oil.
“As parents, we give ourselves the daunting task of fixing everything. When your child is diagnosed with a developmental disorder like autism, the desire to fix things is even more exaggerated,” she says. “Treatment for autism takes time. Parents see CBD oil as this option that can address some of the needs in a way nothing else can.”
But despite how tempting CBD oil may be as an autism treatment, Silverman says it’s “not an intervention with an evidence base.” It’s also not an FDA-approved method for treating autism.
Here are a few more issues surrounding the treatment of autism with CBD oil:
Some parents may also wonder about the legal issues regarding CBD oil. Some states allow CBD oil as long as it’s derived from hemp, but not from marijuana. Other states outlaw CBD altogether, and some permit it for certain uses. Research your own state’s legislation for more details.
So what’s the bottom line? If you’re considering treating your child’s autism with CBD oil, thoroughly research the positives and negatives. Talk to your child’s doctor – or someone who is well-educated in using CBD oil for medical purposes. And when it comes to choosing products, try finding out how much THC it contains. It’s always best to be an informed consumer when making decisions regarding your child’s health.