Can You Take CBD Gummies While On Antibiotics


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While CBD oil is generally considered safe, is it okay to use while on antibiotics? Get the answer here. Are you looking for an answer to the question, "does cannabis affect antibiotics?"If so, you're not alone! …

Antibiotics and CBD Oil: Safe to Take Together?

With new health benefits constantly being discovered, CBD oil has been one of the most exciting medical developments of this century. But almost 100 years before cannabidiol came into the spotlight, antibiotics completely revolutionized medicine and have held their place as a staple of healthcare since.

Together, could this combination be a powerful dream team? Or a match made in hell?

People around the world take CBD oil for a range of conditions; whether for sleep, mood, muscle repair, pain relief, or inflammation control, it can become an important part of your daily routine. Understandably then, if you are told you need to take antibiotics, you’ll want to know whether you can continue to use CBD oil.

Understanding the potential advantages and disadvantages of using CBD oil in conjunction with antibiotics will help you to make an informed decision on how best to carry out your treatment. But as always, this article serves only to educate and should not be substituted for medical advice. Always consult your doctor before using CBD oil with antibiotics.

CBD Oil and Antibiotic Interaction

CBD oil is widely considered to be a safe product that is well tolerated by the majority of people and carries a low risk for side effects. However, when combined with certain pharmaceutical medications, care must be taken. This is due to the relationship between CBD oil and the cytochrome P-450 enzyme system.

Located in the liver, the P-450 system contains more than 50 enzymes that help your body break down toxins. Many common medications are processed through this system, though common antibiotics like penicillins are actually inhibitors of this system as well. The only antibiotics processed by the P-450 system are clarithromycin (Biaxin) and erythromycin.

If you’re taking either of these antibiotics, CBD oil could slow down the time it takes your body to process them in what is referred to as the ‘grapefruit effect.’ (Grapefruit also inhibits the P-450 system.) This inhibition increases the amount of time the medication’s active ingredient is present in your system, and can make it more likely that you’ll experience side effects.

Generally speaking, it isn’t necessarily unsafe to take CBD oil and antibiotics together, but it’s important to understand how the combination could affect you. So, talk to your doctor before you begin using CBD oil and antibiotics together. You can also consult a naturopathic doctor who specializes in using cannabidiol to treat certain medical conditions.

Effectiveness of Using CBD Oil and Antibiotics Together

CBD oil and antibiotics both fight infection, but they don’t do it in the same manner.

While different types of antibiotics vary in their method of fighting infection, they all have a general function: targeting the elements of bacterial cells that aren’t present in human cells. This is an incredibly thorough method of fighting infection; it wipes the slate clean, so to speak, destroying all bacteria in the body, even the good bacteria (probiotics) that keep your gut healthy. Your medication will also exclude any bacteria that have become resistant to antibiotics.

CBD oil has been shown to have antimicrobial properties, making it another tool for fighting infection. While we don’t yet understand how CBD oil fights bacteria, studies have confirmed that this is the case, and that it is particularly useful in attacking bacteria that have become resistant to traditional antibiotics.

One such study investigated how various cannabinoids, including CBD and tetrahydrocannabinol (THC), affect pathogenic bacteria. Each cannabinoid was tested against six strains of the antibiotic-resistant superbug MRSA. All of the cannabinoids showed “potent activity” against the bacterium, with researchers noting that “activity was exceptional against some of these strains, in particular, the multidrug-resistant (MDR) SA-1199B” and also “against EMRSA-15 and EMRSA-16, the major epidemic methicillin-resistant S. aureus strains occurring in U.K. hospitals.” In other words, cannabidiol was proven to be effective at fighting one of the most treatment-resistant strains of bacteria medicine has seen.

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If you can get the dosages right, using CBD oil with antibiotics can offer a powerful, two-pronged approach to fighting bacteria-generated illnesses. Or, after consulting your doctor, you may choose to try using a high-concentration CBD product on its own to fight infection at first. This will preserve the good bacteria in your body and may help reduce the growing number of treatment-resistant bacteria in the world today, which come as a result of unnecessary and incorrect usage of antibiotics.

Side Effects of Using CBD Oil with Antibiotics

As mentioned above, CBD oil may slow down your ability to metabolize clarithromycin (Biaxin) and erythromycin. It’s important to note here that these two antibiotics can be prescribed on their own and may also be included in medications that contain a mixture of antibiotics. This is why it’s important you read your labels and consult your physician.

Since CBD slows the breakdown of these antibiotics, your chances of experiencing their side effects could increase.

If combining CBD oil and clarithromycin, you might be more likely to experience side effects like:

  • Nausea
  • Diarrhea
  • Headaches
  • Mood changes
  • Weakness
  • Stomach Pain

If combining CBD oil and erythromycin, you could have a higher chance of experiencing side effects like:

  • Nausea
  • Diarrhea
  • Stomach pain
  • Liver disease
  • Muscle weakness

CBD Oil for Side Effects of Antibiotics

Antibiotics have saved hundreds of millions of lives since penicillin was first discovered in 1928, but they come with some side effects, too.

Until CBD oil’s antimicrobial effects are better understood, its greatest use in combination with antibiotics may be mitigating their side effects.

Generic Name Common Side Effects CBD Oil
Amoxicillin Nausea; vomiting; stomach pain Combats nausea and vomiting and reduces the experience of pain
Azithromycin Nausea; vomiting; stomach pain Combats nausea and vomiting and reduces the experience of pain
Clindamycin Nausea; vomiting; joint pain Combats nausea and vomiting and reduces the experience of joint pain associated with conditions like rheumatoid arthritis
Cephalexin Nausea; vomiting; stomach pain Combats nausea and vomiting and reduces the experience of pain

Because CBD oil has properties that counter the most common side effects of antibiotics, many people report that when combining the two, they don’t experience any side effects at all. While this is only anecdotal, it is certainly worth considering.

Best CBD Oils to Use with Antibiotics

If you are using CBD oil and need to take a course of antibiotics, speak to a medical professional to discuss the best way forward. Once you have the thumbs-up from your physician, it’s time to choose your CBD product!

To make sure you’re shopping with high-quality CBD oils brands, look for third-party lab testing and Certificates of Analysis. Certificates of Analysis give you the chance to see exactly what is in your CBD product, especially in the way of potency and safety. Finding an organic CBD product will further ensure you’re getting premium CBD oil without any dangerous pesticides or herbicides.

You may also want to think about the method you’ll use to take CBD. If, for example, you have a chest infection, you may feel more comfortable taking your CBD oil in capsule form as opposed to using a vape pen. Explore what your CBD brand of choice has to offer, and reach out to them for the most accurate information about how long it will take the effects to set in, and how long they will last for.

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CBD Oil Dosage

Because the amount of CBD oil required to show effects depends on a number of factors like your metabolism, age, and weight, there is no one dose that can be applied across the board.

It’s best to start with the lowest recommended amount that appears on your product. From there, the dose can be adjusted up or down as needed. With no significant side effects, no intoxicating effects, and no risk for overdose or addiction, you confidently experiment with dosage and concentration until you find what works best for you.

Does cannabis affect antibiotics?

If so, you’re not alone! A lot of people are curious about this topic.

In this article, we’ll answer frequently asked questions about cannabis and antibiotics such as “can you smoke weed on antibiotics?”, “does weed affect antibiotics?”, “can I take CBD oil while on antibiotics?” and more!

If you’re ready to answer questions about how cannabis affects antibiotics then keep reading!

Can you smoke weed on antibiotics?

Antibiotics are used to treat bacterial infections by either killing the bacteria or stopping its growth. Some strains of bacteria have become resistant to antibiotics, making infections more difficult to treat.

The answer to the question “Can you smoke weed on antibiotics” isn’t as cut and dry as you might think. Due to federal prohibition on cannabis, researchers are unable to conduct the kind of extensive clinical trials necessary to determine precisely how cannabis interacts with antibiotics.

Additionally, the answer depends on what type of antibiotics you’re taking, the cannabis product you’re consuming, and your genetics.

In general, you should ask your doctor or health care provider if it is safe for you to use cannabis while taking prescription antibiotics. When you ask your doctor if you can smoke weed while taking antibiotics, be specific about what you’re consuming – including the terpene and flavonoid content if possible. This information will help your doctor assess if there are any concerning interactions.

Can you smoke on antibiotics?

Terry Roycroft, founder of the Medical Cannabis Research Center (MCRCI), stated in an interview that antibiotics have very few negative interactions with cannabis and that researchers are testing to see which antibiotics work better when paired with cannabis.

On the other hand, Jessie Gill , founder of Marijuana Mommy and a Registered Nurse, states that smoking marijuana can put you at a higher risk of experiencing adverse side effects or reactions to an antibiotic. She says this is especially true with the use of macrolide antibiotics like Troleandomycin .

Adverse reactions are more likely to occur when taking Troleandomycin and smoking weed because cannabis inhibits the production of cytochrome p450 , an enzyme produced in the liver. When this enzyme isn’t present, the liver can’t synthesize certain hormones or break down certain types of medications.

Cannabis and antibiotics

According to Dr. Kent Vrana , Professor and Department of Pharmacology Chair at Penn State University, there are 57 medications that can have cannabinoid drug interactions. Antibiotics are among the 57 medications.

Dr. Vrana concludes that doctors should take cannabis consumption into account when managing a patient during hospital stays or deciding on a medication.

Can I smoke weed while on amoxicillin?

It is advised to avoid smoking weed while taking amoxicillin as some research suggests that delta-9-tetrahydrocannabinol (THC) may reduce the effectiveness of certain antibiotics, such as Amoxicillin, Erythromycin, and Levofloxacin.

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Combining this type of antibiotic with THC may lead to side effects such as:

  • Abnormal behavior
  • Anxiety
  • Confusion
  • Depression
  • Hallucinations
  • Increased blood levels of cannabis
  • Paranoia
  • Seizures

Currently, health care professionals and researchers differ as to whether smoking weed while taking antibiotics is safe or should be avoided.

A helpful resource to determine whether or not smoking and/or consuming weed will interfere with your antibiotics is the cannabis drug interaction database from

Do weed edibles affect antibiotics?

Cannabis edibles contain THC, which can interact with some types of antibiotics. If you are eating a weed edible with THC, it could have an interaction with your antibiotics. If you need to take edibles, it is important to be open with your doctor about any cannabis products you are using.

Can you eat edibles on antibiotics?

Because cannabis edibles may interact with some types of antibiotics, it is advisable to not eat edibles while on antibiotics – unless your doctor gives you the go-ahead.

The reason why you shouldn’t eat edibles while on antibiotics is the same reason you shouldn’t smoke weed while taking antibiotics.

Cannabis consumption can inhibit the production of the liver enzyme cytochrome p450, resulting in adverse reactions from antibiotics. It is not recommended to mix antibiotics and edibles.

Can I take CBD oil while on antibiotics?

So, THC interacts with some types of antibiotics. But you may be wondering, “can I take CBD oil while on antibiotics?” or “does CBD interfere with antibiotics?”

CBD, like THC, inhibits the production of the liver enzyme cytochrome p450. This enzyme helps the body process about 60% of medications. When CBD inhibits the production of cytochrome p450, the interaction of CBD and antibiotics can cause adverse side effects.

While more research is needed, there is some evidence to suggest that the consumption of CBD may make some antibiotics function better. As a result, it is important to inform your doctor if you consume CBD products like CBD oil, as the typical antibiotic dose may be too much and result in adverse side effects.

Key takeaways about cannabis and antibiotics

  1. Smoking weed while taking antibiotics may reduce the effectiveness of antibiotics.
  2. You should avoid eating edibles while taking antibiotics.
  3. Consumption of CBD may make some antibiotics function better.
  4. It is important to let your health care provider know if you consume CBD and/or THC, in what form(s), and how much.
  5. More research is needed on the effects of cannabis and antibiotics together.

Do you have a question about cannabis consumption and antibiotics that we didn’t cover? If so, leave us a comment. We’re happy to get you an answer.

Get started on your cannabis wellness journey

Have you started your cannabis wellness journey? Jointly is a new cannabis wellness app that helps you discover purposeful cannabis consumption so you can achieve your wellness goals with cannabis and CBD. On the Jointly app, you can find new cannabis products, rate products based on how well they helped you achieve your goals, and track and optimize 15 factors that can impact your cannabis experience . These 15 factors include your dose , the environment in which you consume cannabis , who you are with when you ingest , how hydrated you are , the quality of your diet , how much sleep you got last night , and more. Download the Jointly app on the App Store or the Google Play Store to get started on your cannabis wellness journey.

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