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Benadryl and cbd oil for dogs

Benadryl For Dogs: What You Need To Know

Benadryl is one of the most popular over-the-counter allergy medications on the market. If you’ve ever snuffled up once the spring winds start blowing or experienced mild symptoms after a brush with a specific allergen (dander, grass, insect bites), you’ve probably been offered Benadryl. That is if you don’t already take it regularly yourself.

But did you know that many dog owners give their furry friends Benadryl, and not just as an allergy medication? Benadryl (generic name diphenhydramine) has been used to treat a wide swath of symptoms in dogs, from motion sickness and anxiety to as an adverse reaction inhibitor after heartworm treatment or mast cell therapy.

Innovet has put together a complete guide to the information and resources you need to know about before trying diphenhydramine on your dog, from dosage to vet recommendations to potential side effects of Benadryl. Remember that before ever putting your dog on a new drug, you should always consult your veterinarian.

What is Benadryl?

To understand what the diphenhydramine drug known as Benadryl is, you must understand what an antihistamine is and understand what an antihistamine is. You must understand what a histamine is. They are a substance produced by your immune system. They’re like white blood cells for allergies, meaning they target potential threats to the system and automatically act to eliminate them.

The reason you get sneezing, sweating, and watery-eyed symptoms during an allergic reaction are because histamines are trying to expel the foreign allergen from your body. Sometimes, these chemicals get a little carried away; however, the body cannot reign them fast enough. That’s how severe allergies can cause symptoms such as the closure of the breathing passage and cardiac arrest.

This is where antihistamines come in. These are the compounds present in high dosages of diphenhydramine. What they do is block cells’ histamine receptors, meaning allergic reactions are prevented from occurring. Many doctors and veterinarians are encouraging Benadryl use in their human and dog patients, understanding that when allergic reactions come, they can come on suddenly and severely, leaving little time for crisis response.

Many who suffer from common food-borne or other allergies, who develop troubling, but not life-threatening enough symptoms to require something like an Epipen, keep a little of the medication with them at all times.

Is Benadryl Safe For Dogs?

It should be said that the FDA has not cleared Benadryl for veterinary use. Still, most veterinarians you talk to will tell you that a reasonable dosage on a clearly afflicted dog will do nothing but alleviate their symptoms, actually making them safer than had they not taken the drug. Benadryl can be a perfectly safe and healthy course of treatment for anxiety, allergies, and more in your dog, but there are a few things to check first.

It’s important to keep a running list of any medications your dog might already be on. Veterinarians frequently prescribe medications like nervous system depressants and anticoagulants after dogs have surgery. But these medications can interact poorly with Benadryl, sometimes worsening the symptoms of allergic reaction.

Keep in mind that every dog is different. Your dog’s size, body mass, diet, exercise regimen, and general temperament will factor into the drug’s effect on them. What’s safe for a German Shepherd isn’t necessarily going to be safe for a Pekinese. This is another reason to consult your veterinarian before you give your dog Benadryl.

When is Benadryl Prescribed For Dogs?

Benadryl can be prescribed to dogs by a licensed veterinarian for a number of symptoms. Below are four of the most common:


If Benadryl is good enough for your sneezing and snuffling, it’s good enough for your dog. The canine immune system is similar enough to humans’ so that Benadryl can be a safe and effective treatment for mild to moderate allergic reactions. If the allergy symptoms are severe, of course, see a veterinarian immediately.


Too many dog owners have learned to resort to extreme measures to get through New Year’s Eve and the Fourth of July. That is, to get their dogs through the trauma of fireworks. Many dogs get crippling anxiety from loud noises, over-activity, and more. Benadryl has a unique effect on serotonin, which makes you drowsy. Sleepy dog = less anxious dog.

Motion Sickness

In the same way that Benadryl’s sleep-inducing effect can be used to treat anxiety, it is serotonin modulating, anti-inflammation effects can soothe dogs who are prone to nausea on long car rides.

Mast Cell Tumors

Mast cells are white blood cells that play a role in responding to allergic reactions. It’s no surprise that when a dog develops a tumor in their mast cell that histamines are overproduced, sending dogs down a spiral of allergic reactions. Veterinarians often prescribe Benadryl to dogs to combat this condition.

Benadryl Dosage For Dogs

Okay, Benadryl is safe for your dog, and can be used to treat several symptoms. But how much should you give them, and in what form? These are great questions to consider with your veterinarian, but we’ll go through the basics here.

Benadryl is generally prescribed to dogs by veterinarians in tablet form. Wrap it up in their favorite treat, and they’ll gobble it down without a second thought. If your dog is on the discerning side or is known for being a pill splitter, ask your vet about liquid Benadryl that you can mix into water.

How much of the drug you give your dog depends entirely on their size (but don’t forget those other factors – diet, exercise, and temperament). You do not want your dog to overdose on the drug, which can result in constipation, seizures, and a rapid heart rate. The dosage weight guide is as follows:

30lbs or lighter – 10mg dose

30 to 50 lbs – 25 mg dose

Over 50 lbs – 50 mg dose

If you’re ever confused about what these dosage sizes look like, you can call your veterinarian’s office to confirm.

Possible Benadryl Side Effects in Dogs

While it is generally safe to administer Benadryl as an allergy medication to dogs, there are potential side effects to watch out for.

Some of the most common and least concerning side effects include sedation, dry mouth (and alternatively, hypersalivation), and heightened heart rate.

Some side effects that are on the troublesome side can be diarrhea and vomiting (both rare) and urinary retention. If your dog suffers from prostatic hypertrophy or bladder neck obstruction, consult your veterinarian. It may not be a good idea to use Benadryl for dogs.

If your dog lives with any of these other conditions prior to ingesting the Benadryl, check with your vet first, but consider holding off:

  • Glaucoma
  • Severe Heart Failure
  • High Blood Pressure
  • Allergic Lung Disease
  • Pregnancy

If a side effect is going to pop up, it’s almost always going to pop up within the first hour after dosage. So keep an eye on your dog, and if their condition alarms you, remain calm and call a vet.

Alternatives To Benadryl For Dogs

Benadryl is generally a safe, fast-acting, and effective medication. But it isn’t right for everyone. If your dog lives with any of the previously mentioned conditions, or you administered the medication to them, and they reacted adversely, there are alternatives to consider.

CBD has proven to be a remarkable treatment for all the same conditions Benadryl is prescribed for in dogs, from allergies to anxiety. The many benefits of CBD begin with the fact that it is a naturally-derived compound. While most vets would tell you Benadryl is perfectly safe if you’re still nervous, the potential side effects of CBD pale compared to that of the medication.

CBD’s natural active ingredients can also improve your dog’s overall health and beauty, from promoting brightness in dull coats to soothing dry skin to healing cracked paw pads. CBD also boasts the benefit of micro-dosability. Whether you’re administering Innovet’s PurCBD+ PhytoCannabinoid Oil or the delicious Hemp Soft Chews, you can control how much CBD your dog is getting through tincture measurement down to the last drop.

It’s not the only alternative on the market, but CBD is certainly one of the most exciting new products for treating allergies, anxiety, motion sickness, and more in your pet. The volume of clinical research on CBD’s active ingredients in pets also testifies just how effective it can be.

Doing What’s Best for Your Dog

There is a trove of peer-reviewed clinical research and first-hand accounts of the benefits of Benadryl for dogs online, and you should spend some time looking through it. What you absolutely must do before considering Benadryl for dogs is consult your veterinarian.

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Get to know your dogs’ allergies, tabulate the right Benadryl dosage (or the right CBD dosage), and sit back and discover how much happier your dog’s life could be.

Innovet Pet Products brings pet owners together with licensed veterinarians, health, hygiene, and wellness experts to provide you with the best information. All our efforts are focused on developing the safest, most innovative CBD products, grooming solutions, and animal necessities and educating our customers about them in an engaged, shame-free way.

To find out more about Innovet’s best-selling health products, pet accessories, our dosing calculator, and to read about our story, you can visit our website.

Natural Alternative to Benadryl for Dog Allergies

Using Benadryl for dog allergies is often some pet parent’s go-to when looking for a quick way to soothe allergy symptoms. However, although using Benadryl for dog allergies is fast-acting, it doesn’t treat the root of the problem, and it could come with some heavy baggage. That’s why more pet parents are now searching for a natural alternative to Benadryl for dog allergies. Here at CBD Dog Health, we believe the best course of action is determining the root cause of the allergen and using natural supplements to boost the body’s natural defenses. Inflammation is at the root of much of our pets itchiness. One thing that CBD and Benadryl have in common, is that they both target and reduce inflammation.

For most people, CBD is a new thing or can be intimidating (which is why we made this CBD guide for pet parents), making pet parents more likely to run to the store and grab a bottle of Benadryl when the scratching starts. Honestly, who would have thought CBD could help allergies and itchiness? But, it does, and we’re happy to share how!

Table of Contents

What Is Benadryl?

Benadryl, a brand name of the drug Diphenhydramine, is an over-the-counter antihistamine. It’s most often used to treat mild allergy symptoms in humans, though pet parents are often advised to use it for their dog as well.

Benadryl is often used to help relieve symptoms of hay fever, seasonal and other allergies, symptoms of the common cold, as well as itchy skin due to bug bites, hives, and other causes. Due to the sedative effects of Benadryl, it can also be used for motion sickness in dogs, and some pet parents also choose to use it as a way to reduce anxiety in dogs. V eterinarians have also been known to prescribe Benadryl for Mast Cell Tumors as well.

How Does Benadryl For Dog Allergies Work?

Allergies are an immune response to an otherwise harmless substance, perhaps food or something environmental. The immune system responds to the triggering allergen by releasing histamine. When histamine binds to cell receptors, it stimulates changes in the cells that lead to the release of chemicals that cause sneezing, itching, and increased mucus production. Histamine causes all those symptoms we associate with allergies, in an effort to get those allergens out of the body.

Antihistamines, like Benadryl, block histamine activity, seeking to stop that allergic reaction. Benadryl’s active ingredient, Diphenhydramine, is a receptor antagonist, which just means it works by blocking the receptors that receive histamines. With antihistamines, like Benadryl, the body will still produce histamines, but the cell receptors are blocked from recognizing them, which stops those allergy symptoms.

So what does this mean for your pet’s allergies? It means Benadryl is indeed a quick way to relieve allergy symptoms, however it is not addressing your pet’s immune system response or the allergens triggering the response. It is simply addressing the symptoms, and not the cause.

Is Benadryl Safe For Dogs?

Benadryl is not yet FDA-approved for veterinary use, however it is still commonly used in veterinary practices across the U.S.

Benadryl can cause mild or serious side effects.

Common Side Effects of Benadryl in Dogs:

  • Excessive drowsiness
  • Dry mouth
  • Hypersalivation
  • Urinary retention
  • Rapid breathing
  • Increased heart rate

Rarer side effects include diarrhea, vomiting, and change in appetite.

Can My Dog Overdose On Benadryl?

Dogs, and humans, have been known to overdose on Benadryl. An overdose can be fatal.

If your pet is experiencing an overdose, you’ll likely see the Central Nervous System become overloaded, resulting in:

  • Dilated pupils
  • Rapid heartbeat
  • Agitation
  • Constipation
  • Seizures
  • Fatality

The moment you think your dog could be overdosing, it’s critical to call your emergency veterinary hospital immediately.

Although online challenges may encourage it, it is not safe to take more than the recommended dosage of Benadryl. Doing so can lead to overdose and severe symptoms, including abnormal heart rhythms, hallucinations, seizures, and even death in rare cases.

CBD: A Natural Alternative to Benadryl for Dog Allergies

So how can CBD for dog allergies help? CBD and the other compounds found in a full-spectrum hemp extract work to bring the body’s systems into homeostasis. That’s just a fancy way of describing a state of balance.

There are tons of cannabinoid receptors throughout the organs that control our pet’s immune systems. Instead of turning off the immune responses, as Diphenhydramine does, CBD instead increases communication between cells in the immune system. This means CBD for dog allergies can encourage a more moderate and targeted response to allergy symptoms.

Additionally, compounds found in cannabis that reduce inflammation are abundant and diverse. The most abundant phytocannabinoids in cannabis, THC and CBD, both have strong anti-inflammatory properties, while CBC, CBG, and THCV have also demonstrated anti-inflammatory properties.

Inflammation has long been a well-known symptom of most infectious diseases. However, research now suggests that chronic inflammation is not just a symptom, it actually causes and advances many common diseases. Allergies, anxiety, chronic pain, and autoimmune disease, are all examples of conditions associated with inflammation . When we soothe that inflammation, we are addressing the cause of the problem and therefore the hurt.

At CBD Dog Health, we designed the EASE: CBD Oil for Dogs to specifically target allergies in pets. A great natural alternative to Benadryl for dog allergies, EASE also contains frankincense and turmeric, whose anti-inflammatory and immune supportive properties work synergistically with CBD. Additionally, t he skin is often the first place allergy symptoms appear, so our SOOTHE salve is formulated to provide localized relief . For a truly holistic approach, we recommend addressing chronic conditions from all possible angles. That’s why dogs suffering from allergies do so well when combining the effects of EASE and SOOTHE for both localised and systemic allergy relief for dogs. We’ve bundled EASE and SOOTHE together for bigger savings in our Allergy Duo.

Giving full disclosure, holistic pet care and natural plant medicine may not produce the instant gratification that Benadryl produces. This is because CBD oil communicates with the body in an effort to target the root cause, and encourage homeostasis in the body. Holistic medicine seeks to address each animal as an individual with respect to the complexity of their specific needs.

Is CBD Safe For Dogs?

Full-Spectrum hemp extract is extremely safe for both short and long term use. Numerous studies have proven the safety of cannabis based medicine at even extreme high doses. Doses of up to 640.5 mg of CBD rich extract were well tolerated by dogs, with only mild adverse effects.

The potential side-effects that can occur with a full spectrum hemp extract are mild and usually temporary. In most cases, the worst side effects are mild diarrhea or lethargy upon starting CBD. There are also plenty of great herbal remedies to support these symptoms, and as the body gets used to a new dietary supplement, these occurrences fade away.

Dosing CBD for Dog Allergies

Despite common misconceptions, dosing CBD has very little to do with your dog’s size and weight. Sensitivity can range greatly between dogs, and can even change over time, based on age or chronic illness. Dosage is most effectively determined with consideration for each animal’s unique physiological condition.

In the case of CBD for dog allergies, we recommend a dosage ranging from 9-18 mg a day. Best way to administer is applied directly to the gums, in two to three separate applications throughout the day for consistent use.

Our EASE tincture is specially formulated so that one full dropper (1mL) is one standard dose of 9mg of CBD for dog allergies. For localized relief of these acute allergy symptoms, there is nothing better than a topical CBD product, like our SOOTHE salve. Our salves can be applied 2-3 times a day, as needed.

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Pet parents are often highly concerned that they will give too much CBD and cause harm to their pets. More often than not when a pet is not having the desired reaction, it is because the pet isn’t getting the dosage they need for their ailment. If you feel nervous about experimenting to find the upper limit of their sensitivity, rest assured, it is completely safe.

Final Thoughts on Dog Allergies

We know how difficult it is to watch your pet constantly itching and scratching, or suffering from worse allergy symptoms. Unfortunately, without finding the root cause, your pet isn’t going to actually get better and the relief will be temporary.

Make sure to look into the possible triggers of your dog’s allergies. Consider sensitivities to particular foods in their diet, chemicals in their environment and look for ways to encourage the proper functioning of the body’s natural immune responses. There is so much that goes into the proper functioning of our pet’s body and their immune system. 70% of the immune system is housed in the gut. For this reason, good gut health is fundamental to overall wellness. Remember to be your pet’s biggest advocate, we want to help our pets live their best life, instead of just finding quick solutions to cover up symptoms.

CBD Drug Interactions: Which Medications Should You Avoid

Next to CBD and the benefits that can help treat a long list of medical disorders, the other thing that has driven its popularity is its low risk for causing side effects. In fact, research shows CBD can be so safely used that it has the potential to replace other drugs typically used to manage pain, inflammation, anxiety, and on. In fact, in the case of certain epilepsy disorders, there are even times when CBD is the only thing that truly helps. None of this isn’t saying that using CBD doesn’t carry along minor side effects, which we will discuss in more detail later on.

While generally noted for its low side-effect profile, research shows CBD does have one significant side effect of note. And that is the potential for it to interact with certain prescription drugs that are metabolized by a family of enzymes. Known as Cytochrome P450, these enzymes, in particular, CYPA4, are responsible for breaking down about 60 percent of clinically prescribed medications.

While this news jumps out to many as incredibly alarming, it’s not uncommon for foods, supplements, and common medications themselves to inhibit CYP enzymes, causing drug interactions. Grapefruit, St. John’s wort, and kale can all cause drug interactions by inhibiting the same enzymes CBD products can. Then foods such as broccoli, spices like cumin, and drinks like coffee can all interact with the medication we take.

Because many of these are common items in a human’s diet, one way to quickly find out if CBD could interact with the medications you’re taking is to look on the drugs’ label for warnings about eating certain foods, in particular, grapefruit. This isn’t so easy with medications for our pets, however that’s why we are here to help. Because including CBD in our dogs and cats’ health regime is a great way to give them the health they deserve. The therapeutic effects of CBD are countless, and we will be covering the main health benefits in addition to advising you on how to safely use CBD alongside other medications.

What Happens When CBD Inhibits The Cytochrome P450 System?

By temporarily inhibiting cytochrome P450 enzymes, CBD along with the other cannabinoids found in all cannabis plants are able to delay the rate they break down their intended medication.

The metabolism rate of a drug is quite important for several reasons and must be known before an appropriate dosage can be prescribed. By delaying a drug’s metabolism rate, CBD can allow for too much medication to be in your system at once. And in essence, by raising the drug’s potency, this acts as if you took a higher dosage of that drug than normal. By effectively raising the dosage, you’re often increasing the risk for the said drug to cause side effects.

Research on the significance CBD can interact with other medications is still heavily being looked into, and discussed below. Anecdotally, we know that both marijuana and hemp products are commonly used alongside other medications. As we know, there is no great worry in the marijuana community at large about their use interacting with their prescribed medication. The same can’t be said when it comes to the side effects to memory and motor control due to the high amounts of THC found in these plants.

We can theorize from this, that while cannabis products can cause drug interactions and it is not something to take lightly, it’s not significant enough by large to cause a great concern amongst its users. It is important to note that Delta-9-tetrahydrocannabinol (THC), limited to 0.3% in CBD products vs 20%+ in marijuana is heavily involved in inhibiting CYP enzymes. Both CBD and THC are metabolized by CYP3A4 while THC is also metabolized by CYP2C9 and CBD by CYP2C19. From what we currently know, the less CYP are enzymes inhibited, the less chance it can interact with other medications. Along with its inability to cause a high, along with being available for kids and pets, this is another reason CBD oil may be the preferable choice vs medical marijuana.

However, don’t let this trick you into thinking that there isn’t good evidence that we shouldn’t be concerned about it. We have studies that show evidence of CBD itself raising the potency of blood-thinning medication along with seizure medication, causing a higher occurrence of side effects vs. the control groups.

Using CBD Safely With Other Medication

While CBD and other CBD products have the ability to interact with around 60% of prescribed medication, there are several ways to safely use CBD in conjunction with other medications.

First, never stop giving your pet medication prescribed by your veterinarian until you’ve consulted them. This goes for medication that may have a potential interaction with CBD and medication that doesn’t.

From starting CBD off at a lower dose than normal to timing out when CBD should be given to allow for the prescription drug to break down first, there are lots of little things that you can do to improve the safety of CBD. Your veterinarian can help you with these. As well, they can monitor blood plasma levels to ensure your pet’s medication is being properly metabolized or if it could do for a dosage adjustment.

There are times when CBD is touted for its ability to lower the reliance or dosage of prescription medication. One reason this happens is that CBD offers its own benefits. But the other reason we speculate this happens is that CBD may be raising the potency of the other medication in the body.

Last, even in the rare case your pet can’t ingest CBD due to a drug interaction, all hope of ever giving them CBD isn’t lost. The beneficial compounds found in CBD, and in hemp and cannabis products can be administered topically. CBD lotions, salves, and creams are great for help with surface-level aches and pain, skin breakout, inflammation, and more, These do this by avoiding entering the bloodstream, largely preventing CBD from interacting with Cytochrome p450 enzymes.

The skin is the largest organ and the first level of defense against nasties that can put severe stress on the body. Including CBD and hemp in your pet’s skincare regime is a great way to care for their general health.

Side Effects Of CBD

Without a doubt, the biggest and in most cases, the only side effect that comes from using CBD is its ability to interact with other medications. However, there are some minor side effects to be aware of. In most cases, these side effects occur when too large of a dose is given. CBD has a biphasic effect where low and common dosages can put a slight pip in your pet’s step. However, give your dog or cat too much, and you may find them catching some heavy Zzzz’s on the couch.

Another side effect of CBD, along with other cannabis products, is dry mouth. CB1 and CB2 receptors which make up the endocannabinoid system — the system cannabis largely interacts with — are found heavily in the mouth where they help regulate saliva production. But by the same token, the opposite of dry mouth can happen, and CBD may temporarily boost saliva product/release. CB1 receptors are overstimulated with high-THC products like marijuana. Because there are only trace amounts of it in CBD products, issues like dry mouth are much less commonly seen.

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High doses of CBD can lower resting blood pressure causing some lightheadedness, which should quickly pass. One 2017 study found the potential for CBD to help lower blood pressure in those with high blood pressure.

Nausea and stomach discomfort are frequently cited side effects seen with nearly every medication. This especially happens when first starting a medication due to the body needing to take time to realize it’s not a threat or allergy. The same can happen with CBD, despite it usually having adverse effects and helping with nausea and stomach discomfort. Changing the dosage while the body learns to recognize CBD can help. Usually, a lower than normal dose for a few days to a week is a great course of action for this side effect.

What Research Says

Research on CBD, and cannabidiol itself, and the potential for drug interactions so far has been a bit of a mixed bag. Some researchers have found a low dose of CBD is effective enough in avoiding interactions with the drugs they were studying. While other researchers have found a precise dosage – that can be either low or high – is preferable and dependent on the patients’ and their medications. So how do we interpret this data?

First, the big thing that comes from the studies we have found is while CBD can cause interactions with the medication we take, studies still find CBD is a safe and effective treatment. With simple monitoring and potential adjustments in the dosage, there is little risk to continue using CBD. This is awesome news!

The reason a low dose usually works, but not always for avoiding a drug’s side effects is likely due to the individual cytochrome that’s responsible for the metabolism of the drug. Researchers have found CBD can both speed up and slow down the metabolism rate depending on the drug and the cytochrome it interacts with. Again, while there is some risk with CBD, when given the appropriate care, the data shows CBD is very low risk.

Clinical trials show care and safety should be given in the case of epilepsy because while CBD can significantly help seizures, they can easily interact with seizure medications increasing their side effects, which can produce seizures of their own. However, again, researchers have found CBD and seizure medications can be used together with a smart medical treatment plan. In fact, epilepsy is currently the only thing the FDA has approved the use of CBD for.

Frequently Asked Questions Concerning CBD and Drug Interactions

We hope our article has provided you with all the information you need when deciding if CBD is something you should give to your pet. Especially if they are already on medications. Because we’ve taken such an extensive look at CBD and its potential for causing a drug interaction, we wanted to quickly answer some of the most asked questions concerning the topic.

Can You Take CBD With Medication?

In the large majority of cases, CBD can safely be used with most medications. Using CBD in tandem with over-the-counter medications warrants little to no concern. If using an OTC drug long-term or at a higher than normal dosage due to medical advice from your doctor or vet, please consult said authority before using a CBD product. While a CBD product has the potential to cause drug-drug interplay in about 60% of prescription drugs, for the most part, with the proper medical advice and guidance, CBD can be safely used.

What Meds Does CBD Interact With?

CBD has been shown to interact with blood-thinning drugs like Warfarin, raising abnormal liver enzymes along with inducing tiredness when used in conjunction with Valproic Acid – sometimes used for controlling seizures. This information comes from research on Epidiolex, an FDA-approved cannabis extract for help with epilepsy. Epidiolex is an isolate, meaning it only contains the single cannabinoid, cannabidiol, in very high amounts. Most CBD products aren’t a single cannabinoid but contain the full range including high amounts of cannabidiol.

For a full list of potential drug interactions, please see our list at the end of the article.

Can CBD Interfere With Arthritis Medications?

In the large majority of cases, it’s very unlikely CBD would interfere with the metabolism of drugs used to treat arthritis and other inflammatory joint disorders. For help with pain and joint issues, veterinarians commonly prescribe nonsteroidal anti-inflammatory drugs (NSAIDs) that are safe for dogs. Except for diclofenac, it appears CBD will not have a drug-drug interaction with an NSAID drug. While NSAIDs are commonly given to dogs, the over-the-counter medications we commonly take – like Ibuprofen – should only be given to your dog under the supervision of your vet due to their ability to easily pass the safety threshold in dogs.

Does CBD Interfere With Blood Pressure Medicine?

While high blood pressure and hypertension occur in humans more, our dogs are susceptible to the disease and put on similar medications, as well. Because CBD can lower blood pressure and potentially help those with hypertension, it can seem like a good idea to use it in conjunction with drugs designed to do the same, but caution is advised. While CBD can be used in tandem with blood pressure medications, it’s recommended you discuss it with your veterinarian first.

There are several medications used to treat high blood pressure, including angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), diuretics, and calcium channel blockers. Because of this, if your vet finds they like what CBD is offering your pet, but they see it interacting with their medication, they have the option to switch to a different medication.

Has CBD Ever Caused A Life-Threatening Drug Interaction?

To the best of our knowledge and thorough research, we can not find an example of CBD or any cannabis product causing life-treating drug interactions.

Again, this should not make you disregard potential drug interactions. Instead, we are simply saying that while cannabis can cause such, it’s frequently used alongside other medications, often without the guidance of a health provider, yet for whatever reasons, a crisis has not occurred.

Discussing CBD And Drug Interactions With Your Vet

CBD has a world of therapeutic benefits that can improve our pets’ health in both small and big ways. Backed by research, CBD oil and other CBD products have been shown to be extraordinarily low-risk options for the benefits it has. However, while you can use CBD in tandem with other medications, there is a chance for an interaction that can increase the risk of the drug causing side effects. Interactions cannot happen with all drugs, but a majority of prescription medications (about 60%) have potential. This includes medication commonly used to treat epilepsy, for which CBD is commonly used to help as well.

If your dog or cat is on medication, and you’re concerned about CBD and its potential for drug interactions, your best bet for advice is their vet. While CBD may interact with medications your pet is on, your vet can safely assess if CBD is still the correct choice for them. Often timing out the dosages or changing the dose of CBD or the other medications can allow them to be used together for the best of both worlds.

With proper care, current research indicates CBD can offer a treatment plan an irreplaceable tool for improving health without causing serious adverse side effects, even when there is potential for a drug interaction.

List Of Known Drugs CBD Interacts With

If either you or your pet is on one or more of the medications listed below, please consult the appropriate medical professional before using CBD. Just because a medication is listed below does not indicate that it can never be used in conjunction with CBD or another cannabis product. Nor does it mean you will personally see drug interactions or side effects from them. Instead, it simply means there is potential for an interaction that you should be aware of.

Our aim for this list is to give a comprehensive reference point. However, there is always the chance we could have missed some medications. As well, there are studies and clinical trials dedicated to the research of CBD and drug interactions currently in operations that could change our list.